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Table 2 Differentially expressed proteins in unstimulated CD4+ T cells

From: Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls

Accession

Protein identity

Gene names

p-value

Adjusted p-value

FC MS versus HC (log2)

Median intensity MS (log2)

MS SD

Median intensity HC (log2)

HC SD

% seq cov

# pep

PC1

PC2

Q7L8W6

Diphthine–ammonia ligase

DPH6

2.61E−13

1.49E−09

3.301

24.018

1.032

21.159

0.819

7

2

− 0.253

0.067

Q8TDQ7

Glucosamine-6-phosphate isomerase 2

GNPDA2

2.21E−09

6.31E−06

− 1.851

25.017

0.660

26.798

0.817

64

12

0.156

0.384

Q9UKU7

Isobutyryl-CoA dehydrogenase, mitochondrial

ACAD8

6.47E−09

1.23E−05

1.028

26.741

0.283

25.805

0.501

37

11

0.174

0.331

Q92828

Coronin-2A

CORO2A

4.86E−08

6.93E−05

2.265

23.155

1.130

20.378

0.964

6

3

0.192

0.366

A8MW92

PHD finger protein 20-like protein

PHF20L1

4.32E−07

4.86E−04

1.364

23.108

0.596

21.700

0.787

2

3

− 0.261

0.146

Q9HD15

Steroid receptor RNA activator 1

SRA1

5.11E−07

4.86E−04

1.491

23.969

0.589

22.233

0.895

23

5

− 0.255

0.133

Q9H2F5

Enhancer of polycomb homolog 1

EPC1

9.04E−07

7.36E−04

2.343

23.484

0.405

20.419

1.496

1

1

− 0.292

0.081

Q12923

Tyrosine-protein phosphatase nonreceptor type 13

PTPN13

1.37E−06

9.75E−04

− 1.266

25.186

0.683

26.405

0.715

0

1

− 0.245

0.297

Q8TCE6

DENN domain-containing protein 10

DENND10

2.83E−06

1.79E−03

2.039

25.989

1.239

23.524

1.099

24

6

− 0.263

0.108

O43504

Ragulator complex protein LAMTOR5

LAMTOR5

1.64E−05

8.96E−03

− 1.583

21.906

0.915

23.469

1.097

37

2

− 0.228

0.256

Q9H7Z3

Nuclear exosome regulator NRDE2

NRDE2

1.73E−05

8.96E−03

− 2.441

19.733

1.071

22.690

1.857

2

2

− 0.256

− 0.045

Q16401

26S proteasome non-ATPase regulatory subunit 5

PSMD5

2.14E−05

9.39E−03

0.577

29.015

0.397

28.500

0.353

73

27

− 0.243

0.135

Q9HD26

Golgi-associated PDZ and coiled-coil motifcontaining protein

GOPC

2.03E−05

9.39E−03

− 1.638

22.742

1.172

24.340

0.927

18

7

0.162

0.385

Q12797

Aspartyl/asparaginyl beta-hydroxylase

ASPH

2.91E−05

1.19E−02

2.423

26.114

1.155

22.808

1.895

4

3

− 0.238

0.254

O75764

Transcription elongation factor A protein 3

TCEA3

7.49E−05

2.85E−02

− 1.026

22.367

0.761

23.294

0.698

21

6

0.226

0.302

P08134

Rho-related GTP-binding protein RhoC

RHOC

1.04E−04

3.70E−02

− 2.197

20.231

1.385

23.063

1.776

69

12

0.249

-0.100

P29597

Non-receptor tyrosine-protein kinase TYK2

TYK2

1.19E−04

3.78E−02

1.144

21.722

0.858

20.650

0.829

1

2

0.194

0.238

Q96GS4

BLOC-1-related complex subunit 6

BORCS6

1.18E−04

3.78E−02

0.685

23.655

0.465

23.067

0.539

42

8

− 0.294

-0.046

  1. The table shows the accession number, protein identity and gene names for each protein, in addition to the unadjusted (p-value) and adjusted p-value, the log2-fold changes in MS versus HC based on normalized values, median log2-transformed protein abundances with standard deviation (SD) for each group, the percentage of sequence coverage (% seq cov), the number of peptides (# pep) identified for each protein, and the loadings for the first (PC1) and the second principal component (PC2). Large loadings (cutoff 0.236) are highlighted in bold
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Clinical Proteomics

ISSN: 1559-0275