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Fig. 1 | Clinical Proteomics

Fig. 1

From: Proteomic analysis of low- and high-grade human colon adenocarcinoma tissues and tissue-derived primary cell lines reveals unique biological functions of tumours and new protein biomarker candidates

Fig. 1

Functional enrichments of proteins with significantly differential abundance in CA. A LGCA v LGNC tissues. B HGCA v HGCA tissues. C HGCA v LGCA cell lines. The analyses were performed using STRING online software with a medium confidence level (0.4), providing the significantly enriched GO terms, KEGG and Reactome pathways. The vertical axis displays the significantly enriched biological functions. The horizontal axis indicates the strength of enrichment, which is the log10 (observed/expected proteins in the network that are annotated with a term) and measures how large the enrichment effect is. The higher the absolute value of the strength, the stronger the impact. Positive strength values indicate enrichment amongst significantly upregulated proteins, negative strength values indicate enrichment amongst significantly downregulated proteins. The lists of differentially expressed proteins used to create these graphs are found in Additional Files 5 and 6. Colour codes: the green denotes KEGG and Reactome Pathways; the orange and blue code GO Cellular Component and Biological Process categories, respectively

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Clinical Proteomics

ISSN: 1559-0275