Table 3 Selected proteins with differential expression identified in the CA tissues and/or CA tissue-derived primary cell lines

ACE2

Angiotensin-converting enzyme 2

100 (< 0.001)

100 (< 0.001)

0.725 (0.703)

–

62,63

ACSL4

Long-chain-fatty-acid-CoA ligase 4

1.682 (0.993)

2.403 (0.996)

1.533 (0.946)

2.022 (0.01)

–

ANK2

Ankyrin-2

0.486

(0.03)

0.219

(< 0.001)

0.454 (0.056)

–

–

AMER3

APC membrane recruitment protein 3

–

–

–

0.485 (0.039)

–

CD44

CD44 antigen

1.705 (0.973)

2.263 (0.991)

1.264 (0.999)

2.269 (< 0.001)

55

CIRH1A (UTP4)

U3 small nucleolar RNA-associated protein 4

100

(< 0.001)

100

(< 0.001)

1.693 (0.946)

-

68

CNN1

Calponin-1

0.369 (0.046)

0.22

(0.002)

0.699 (0.305)

0.735 (0.457)

72–74

EXOSC1

Exosome complex component csl4

100 (< 0.001)

100 (< 0.001)

1.196 (0.999)

0.982 (0.983)

–

EXOSC6

Exosome complex component MTR3

100 (< 0.001)

100 (< 0.001)

1.189 (0.999)

1.34 (0.936)

–

FN1

Fibronectin

1.429 (0.963)

3.32 (0.986)

2.358 (0.076)

0.35 (< 0.001)

14,49,50

GCLM

Glutamate–cysteine ligase regulatory subunit

–

–

–

2.723

(0.004)

–

HMOX1

Heme oxygenase-1

–

–

–

3.447 (0.002)

43

MSH6

DNA mismatch repair protein MSH6

0.444 (0.024)

0.304

(0.001)

1.837 (0.775)

2.107 (0.422)

3,4

S100A8

Protein S100-A8

1.66 (0.956)

4.417 (0.897)

2.434 (0.026)

–

18,23

S100A9

Protein S100-A9

1.807 (0.984)

4.855 (0.878)

2.524

(0.02)

–

14,18,23

SDCBP

Syntenin-1

1.565 (0.984)

4.929 (0.781)

2.798

(0.01)

1.547 (0.549)

54

SFRP4

Secreted frizzled-related protein 4

2.031 (0.963)

8.834 (0.093)

3.747 (0.008)

–

52

SMC2

Structural maintenance of chromosomes protein 2

100 (< 0.001)

100 (< 0.001)

2.436 (0.169)

1.459 (0.831)

58,59

TFRC

Transferrin receptor protein-1

2.621 (0.956)

5.358 (0.785)

1.847 (0.391)

2.02 (0.005)

–