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Table 6 List of glomerular basement membrane proteins

From: Comparative proteomic analysis of glomerular proteins in primary and bucillamine-induced membranous nephropathy

Accession ID

NCBInr DB

Accession ID

GenBank DB

Protein name

Sequence coverage (%)

Peptide match (n)

PLA2R (+) pMN patients (n = 6)/Transplantation donors (n = 5) ratio (Ratio variability [%])

PLA2R (−) pMN patients (n = 6)/Transplantation donors (n = 5) ratio (Ratio variability [%])

BCL-induced sMN patients (n = 6)/Transplantation donors (n = 5) ratio (Ratio variability [%])

125987809

 

COL4A1

6

5

0.15* (120.23)

0.07** (91.69)

0.38 (100.14)

116256354

 

COL4A2

5

6

0.77 (47.23)

0.71 (65.75)

0.56 (57.53)

119591260

 

COL4A3

7

6

0.87 (102.70)

1.00 (87.83)

1.39 (74.61)

116256356

 

COL4A4

4

4

0.56 (105.95)

1.12 (83.70)

1.08 (68.49)

1034673478

 

COL4A5

4

4

1.98 (62.44)

1.58 (81.23)

1.48 (72.75)

20147503

 

Laminin α5

19

61

0.80 (95.43)

0.82 (92.06)

0.83 (98.88)

1103585

 

Laminin β2

30

46

1.01 (74.85)

1.06 (80.03)

0.94 (85.94)

145309326

 

Laminin γ1

17

25

0.73 (80.56)

0.92 (77.70)

0.81 (89.79)

119590445

 

Nidogen-1

21

27

1.24 (67.88)

1.23 (67.35)

1.20 (62.93)

530360311

 

Agrin

28

43

0.80 (99.26)

1.00 (100.63)

0.97 (91.60)

11602963

 

HSPG perlecan

15

49

1.12 (82.16)

1.07 (90.05)

1.06 (87.98)

  1. BCL: bucillamine; COL: collagen; DB: data base; HSPG: heparan sulfate proteoglycan; NCBInr: National Cancer for Biotechnology Information non-redundant; PLA2R: phospholipase A2 receptor; pMN: primary membranous nephropathy; sMN: secondary membranous nephropathy
  2. *P < 0.05, **P < 0.01