Table 2 Differentially expressed proteins in SFTS patients
From: Serum proteomics of severe fever with thrombocytopenia syndrome patients
Uniprot_Id | Description | Gene | Recovered patients/normal subjects | Deceased patients/recovered patients | ||
|---|---|---|---|---|---|---|
p-value | log2FC | p-value | log2FC | |||
Complement system | ||||||
P09871 | Complement C1s subcomponent | C1S | 1.0E−05 | 5.666 | 2.2E−07 | − 5.847 |
P13671 | Complement component C6 | C6 | 3.2E−06 | − 1.882 | 0.0031 | − 4.564 |
P10643 | Complement component C7 | C7 | 0.0168 | − 1.125 | 0.0008 | − 4.422 |
A0A3B3ISR2 | Complement subcomponent C1r | C1R | 2.2E−05 | 5.615 | 7.9E−06 | − 2.897 |
P0C0L5 | Complement C4-B | C4B | 0.0092 | 0.867 | 0.0002 | − 1.774 |
P0C0L4 | Complement C4-A | C4A | 4.8E−07 | 2.138 | 0.0001 | − 1.44 |
P02748 | Complement component C9 | C9 | 0.4626 | − 0.243 | 0.024 | − 1.089 |
P11215 | Integrin alpha-M | ITGAM | 0.4126 | − 0.598 | ||
Q5SR44 | Complement receptor type 1 | CR1 | 0.1442 | 1.494 | ||
O00187 | Mannan-binding lectin serine protease 2 | MASP2 | 0.0048 | 1.702 | 0.0323 | 4.416 |
Coagulation system | ||||||
A0A3B3ISJ1 | Vitamin K-dependent protein S | PROS1 | 1.7E−05 | 2.286 | 1.7E−10 | − 6.992 |
E7END6 | Vitamin K-dependent protein C | PROC | 0.0008 | 2.107 | 1.4E−05 | − 4.393 |
P05546 | Heparin cofactor 2 | SERPIND1 | 0.716 | − 0.111 | 0.0021 | − 3.98 |
P01023 | Alpha-2-macroglobulin | A2M | 0.4494 | 0.121 | 0.0026 | − 3.198 |
P12259 | Coagulation factor V | F5 | 0.1737 | 1.225 | 0.0159 | − 2.542 |
P04275 | von Willebrand factor | VWF | 0.5524 | 0.697 | 0.1201 | − 1.945 |
P00740 | Coagulation factor IX | F9 | 0.0348 | 1.425 | 0.0194 | − 1.564 |
P01009 | Alpha-1-antitrypsin | SERPINA1 | 0.4545 | − 0.447 | 0.8891 | 0.092 |
P01008 | Antithrombin-III | SERPINC1 | 0.2133 | − 0.525 | 0.4596 | 0.272 |
P08697 | Alpha-2-antiplasmin | SERPINF2 | 0.0001 | − 2.042 | 0.273 | 0.541 |
P05154 | Plasma serine protease inhibitor | SERPINA5 | 0.8133 | − 0.168 | 0.0001 | 5.42 |
Downstream target of TNF-α and IL-1β | ||||||
P05109 | Protein S100-A8 | S100A8 | 0.0065 | 3.536 | 0.0445 | 3.82 |
P06702 | Protein S100-A9 | S100A9 | 0.0005 | 4.66 | 0.0708 | 2.681 |
P02647 | Apolipoprotein A-I | APOA1 | 0.0077 | − 0.859 | 0.0003 | − 3.788 |
P02649 | Apolipoprotein E | APOE | 0.0525 | 0.935 | 1.1E−07 | − 5.696 |