Table 2 Immune-related proteins with differences between severe COVID-19 cases and controls in our meta-analysis of the BQC-19 and MSB results (Bonferroni adjusted threshold 0.05/147 = 0.00034)
Proteins | P-values | Proteins | P-values |
|---|---|---|---|
Interleukins | Soluble interleukin receptors | ||
IL1A | 9.04 × 10–6 | IL1R1 | 1.50 × 10–8 |
IL1B | 1.21 × 10–6 | IL1R2 | 1.91 × 10–7 |
IL3 | 2.34 × 10–4 | IL1RAPL2 | 4.23 × 10–11 |
IL4 | 1.35 × 10–11 | IL1RL1 | 2.90 × 10–12 |
IL6 | 9.50 × 10–10 | IL1RL2 | 1.45 × 10–4 |
IL11 | 1.14 × 10–10 | IL1RN | 2.89 × 10–6 |
IL12 | 1.26 × 10–4 | IL2RB | 1.04 × 10–4 |
IL13 | 3.04 × 10–7 | IL3RA | 4.37 × 10–7 |
IL17D | 1.66 × 10–8 | IL4R | 1.67 × 10–8 |
IL17F | 2.14 × 10–10 | IL7R | 5.12 × 10–11 |
IL18 | 8.26 × 10–7 | bIL10RB | 6.18 × 10–5 |
IL19 | 2.32 × 10–4 | IL10RA.soma2 | 5.17 × 10–8 |
IL24 | 1.52 × 10–11 | IL11RA | 1.64 × 10–6 |
IL25 | 2.76 × 10–7 | IL12RB1 | 5.46 × 10–13 |
IL36B | 1.52 × 10–9 | IL13RA1 | 5.15 × 10–7 |
IL36G | 1.28 × 10–6 | bIL15RA.soma2 | 1.10 × 10–7 |
aIL37 | 3.17 × 10–4 | IL17RB | 1.22 × 10–4 |
Interferons | IL17RC | 1.02 × 10–4 | |
IFNA4 | 9.47 × 10–8 | IL18RAP | 1.50 × 10–5 |
IFNA6 | 1.09 × 10–7 | IL21R | 1.28 × 10–11 |
IFNA8 | 2.43 × 10–5 | IL22RA1 | 1.66 × 10–14 |
IFNA10 | 4.74 × 10–4 | IL22RA2 | 1.10 × 10–5 |
aIFNB1 | 1.80 × 10–4 | IL23R | 5.80 × 10–5 |
IFNL1 | 6.53 × 10–5 | IL27RA | 2.11 × 10–6 |
IFNL2 | 3.01 × 10–11 | CXCL chemokines | |
IFNL3 | 3.60 × 10–5 | CXCL5 | 4.53 × 10–8 |
CCL chemokines | CXCL10 | 3.22 × 10–9 | |
CCL7 | 5.21 × 10–10 | CXCL12 | 1.21 × 10–4 |
CCL8 | 4.14 × 10–5 | CXCL13 | 1.01 × 10–5 |
CCL11 | 5.23 × 10–6 | CXCL14 | 5.42 × 10–10 |
CCL13 | 4.01 × 10–11 | CXCL16 | 2.26 × 10–5 |
CCL19 | 1.93 × 10–6 | Others | |
CCL20 | 1.30 × 10–6 | M-CSF | 1.60 × 10–13 |
CCL22 | 8.84 × 10–10 | TLR1.soma1 | 2.62 × 10–4 |
CCL23 | 8.15 × 10–6 | LT-α / TNF-β | 2.08 × 10–10 |
CCL24 | 3.50 × 10–10 |  |  |
CCL26 | 2.78 × 10–8 |  |  |
CCL27 | 3.27 × 10–13 |  |  |