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Table 1 The percent of variant allele frequencies (VAF%) of KRAS mutations in tumor tissues prepared by bulk, coring, and LMD techniques

From: Neoplastic cell enrichment of tumor tissues using coring and laser microdissection for proteomic and genomic analyses of pancreatic ductal adenocarcinoma

Case

VAF (bulk)%

VAF (core)%

VAF (LMD)%

Fold changes (core/bulk)

Fold changes (LMD/bulk)

KRAS mutations

C3L-01032

34.2

48.1

45.9

1.4

1.3

p.G12D

C3L-01160

29.5

51.8

30.6

1.8

1.0

p.G12D

C3N-01897

18.5

20.3

26.7

1.1

1.4

p.G12R

C3N-02997

15.1

9.4

20.0

0.6

1.3

p.G12V

C3N-02591

10.3

9.1

21.2

0.9

2.1

p.G12R

C3N-02590

7.7

12.2

33.6

1.6

4.4

p.G12V

C3L-01158

2.7

4.4

17.3

1.6

6.4

p.G12R

C3L-03624

0.8

0.3

6.0

0.4

7.6

p.Q61H

  1. The fold changes of VAFs of coring and LMD compared to VAF of the matched bulk tumors were included to show the neoplastic cellularity enrichment efficiencies by the coring and LMD methods
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Clinical Proteomics

ISSN: 1559-0275