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Table 2 Baseline characteristics of the subjects grouped according to various populations

From: Identification of circular RNA BTBD7_hsa_circ_0000563 as a novel biomarker for coronary artery disease and the functional discovery of BTBD7_hsa_circ_0000563 based on peripheral blood mononuclear cells: a case control study

Characteristic

Circularization

set

Expression set

CHIRP-MS set

CAD (n = 4)

CAD (n = 210)

Control (n = 24)

P value

CAD (n = 18)

Control (n = 20)

P value

Age (years)

65.25 ± 3.95

65.00 (57.00–72.00)

65.00 (61.00–69.00)

0.970

70.00 (53.50-76.25)

63.00 (55.25–69.25)

0.443

Sex (male/female)

3/1

155/55

11/13

0.004

12/6

9/11

0.210#

BMI (kg/m2)

23.21 ± 4.76

24.72 (22.86–27.04)

25.34 (22.86–26.67)

0.582

25.01 ± 3.61

25.35 ± 3.04

0.777

SBP (mmHg)

139.25 ± 24.19

130.66 ± 16.92

129.50 ± 16.55

0.751

130.00 ± 17.60

131.53 ± 13.05

0.768

DBP (mmHg)

82.75 ± 8.34

77.00 (70.00–85.00)

78.00 (73.00–88.00)

0.212

75.53 ± 11.75

79.79 ± 10.04

0.249

Hypertension (n, %)

1 (25.0)

134 (63.81)

15 (62.50)

0.899

15 (83.3)

7 (35.0)

0.007#

Diabetes (n, %)

0 (0)

53 (25.24)

5 (20.83)

0.636

0 (0)

0 (0)

——

Smoking (n, %)

2 (50.0)

85 (40.48)

9 (37.50)

0.778

10 (55.6)

5 (25.0)

0.099#

Drinking (n, %)

2 (50.0)

63 (30.00)

4 (20.83)

0.349

11 (61.1)

5 (25.0)

0.049#

TC (mmol/L)

4.16 ± 0.34

3.54 (2.91–4.44)

4.01 (3.41–4.63)

0.233

3.60 ± 0.67

4.15 ± 0.92

0.043

TG (mmol/L)

1.56 ± 0.81

1.42 (0.98–1.84)

1.16 (0.85–1.62)

0.250

1.27 (1.08–1.52)

1.11 (0.88–1.22)

0.098

HDL-C (mmol/L)

1.24 ± 0.26

0.97 (0.86–1.15)

1.12 (0.97–1.26)

0.060

1.04 ± 0.28

1.22 ± 0.32

0.082

LDL-C (mmol/L)

2.42 ± 0.41

2.02 (1.56–2.66)

2.21 (1.93–2.75)

0.319

1.98 (1.58–2.63)

2.29 (1.96–2.88)

0.065

Fasting blood glucose

(mmol/L)

4.96 ± 0.46

5.21 (4.56–6.20)

5.17 (4.59–5.95)

0.963

4.95 (4.89–5.21)

5.05 (4.73–5.72)

0.704

Serum creatinine

(umol/L)

87.53 ± 26.07

71.90 (63.68–85.10)

67.60 (53.00-78.20)

0.062

69.65 (62.50-79.88)

61.00 (50.23–72.70)

0.051

Gensini score

52.13 ± 29.85

40.00 (22.00–77.00)

1.25 (0.00-4.75)

< 0.001

30.50 (10.00-64.75)

0.00 (0.00-2.38)

< 0.001

  1. Data are expressed as the mean ± standard deviation, median (25th–75th interquartile range), or count (percentage)
  2. #: Fisher’s exact test
  3. CAD, coronary artery disease; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triacylglycerol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol