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Fig. 1 | Clinical Proteomics

Fig. 1

From: Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation

Fig. 1

A Overview of blood samples collection from COVID-19 patientsincluding 8 patients with severe pneumonia who required ICU admission2 patients who died before ICU admission (F: fatal)10 COVID-19 patients with pneumonia who did not require ICU admissionand 10 Healthy volunteers. The workflow for processing the proteomic data are shownincluding the plasma separationabundant protein depletiontrypsin digestionpeptide fractionationLCMS/MS analysisdatabase searchand further computational analyses. B Patients were classified based on the WHO scale from severity ‘‘3’’ (hospitalizedno oxygen therapy) to severity ‘‘6/7’’ (ICU admission) and “8” (death). C Principal Component Analysis (PCA) based on the entire dataset of HD and COVID-19 patients. Healthy and COVID-19 patients are well discriminated along the second principle componentwhile PC1 partially discriminate ICU/F and non-ICU COVID-19 patients

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Clinical Proteomics

ISSN: 1559-0275