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Fig. 4 | Clinical Proteomics

Fig. 4

From: Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation

Fig. 4

A Hierarchical cluster analysis of plasma protein correlation values. Euclidean distance were used to compare different groups and clusters were extracted using either n = 4 or n = 15 to allow a better discrimination of clusters containing lower abundant proteins. B GO pathways enriched among plasma proteins that exhibited progressively increased expression in non-ICU and ICU/F COVID-19 patient groups with respect to HDanalysed in each cluster identified in A. C GO pathways enriched among plasma proteins that exhibited increased expression mainly in COVID-19 ICU/F patient groups with respect to COVID-19 non-ICU and HDanalysed in each cluster identified in A. Top score processes resulting from the GO-based enrichment analysis (see Fig. 3) are highlighted in red

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Clinical Proteomics

ISSN: 1559-0275