Determination of temporal reproducibility and variability of cancer biomarkers in serum and EDTA plasma samples using a proximity extension assay

Table 1 Description of original studies from where data was used

Study	Description of the study	Date of analyses	Version of Olink I-O panel	N plates	N bridging samples included on each plate
BX0144	Protein biomarkers for PC – part of the BIOPAC study	22-Nov-2018 to 06-May-2019	v. 3101	19^a	8
BX0182	Protein biomarkers for cancer diagnosis	01-Oct-2019 to 08-Oct-2019	v. 3111	9	8
BX0188	Protein biomarkers for malignant melanoma	10-Dec-2019	v. 3111	3	7
BX0202	Protein biomarkers for immunotherapy efficacy in PC	24-Mar-2020	v. 3111	2	6
BX0214	Protein biomarkers for colorectal cancer	13-Mar-2020	v. 3111	1	8
BX0223	Protein biomarkers for BTC – discovery – CHOCA study	16-Nov-2020	v. 3111	5	8
BX0263	Protein biomarkers for BTC – validation – CHOCA study	08-Jun-2021	v. 3112	1	8

^a14 out of 19 plates included all 8 samples. On the last 5 plates, the 8 samples were distributed evenly, and for the analysis they were regarded as analyzed on the same plate
I-O immuno-oncology, v version, N number, PC pancreatic cancer, BTC biliary tract cancer, CRC colorectal cancer

ISSN: 1559-0275