Fig. 1
From: Proteomic profiling of end-stage COVID-19 lung biopsies
The most upregulated proteins in lung tissues of terminal COVID-19 patients are involved in immune and stress response, extracellular matrix remodelling, as well as clot formation and fibrinolysis. A Volcano plot of the LFQ diaPASEF dataset after limma analysis (limma dynamic p-value < 0.05) including box dot plots of the most prominently changed proteins. B Grouping of selected significantly enriched biological processes (limma dynamic p-value < 0.05) based on similarity after gene ontology enrichment analysis using String and Enrichment map in Cytoscape with significantly more abundant proteins in COVID-19 (limma dynamic p-value < 0.05, fold change to control > 1.5) as input. C Selected significantly enriched Reactome pathways (enrichment FDR corrected p-value < 0.05) with the same input protein list (as for B)