Fig. 2
From: Proteomic profiling of end-stage COVID-19 lung biopsies
The most prominently downregulated proteins in COVID-19 patient lung tissue mainly belong to the ECM constituent and fibril/filament formation. A String protein interaction network of significantly downregulated proteins in COVID-19 patients (dynamic p-value < 0.05; interaction confidence level 0.7 (high)); B Data from String was further corroborated with IPA predicted “activated” or “deactivated” significantly enriched diseases and functions in COVID-19 patients with significantly altered proteins (p-value < 0.05) as input. Higher Z-score represents predicted increase of the given pathway/function in COVID-19 patients while lower Z-score predicts a decrease (Z-Score cut-off ± 1.5)