Fig. 4

Lungs of COVID-19 patients depict pronounced changes in global, kinase mediated signalling. A IPA analysis of canonical pathways with significantly altered proteins before multi-testing correction (p-value < 0.05) as input revealed prediction of lower activation of a number of different, major kinase signalling pathways. Higher Z-score (marked in yellow) predicted activation, while lower Z-score (purple colour) represents prediction of a lower activation of a given pathway in lungs of COVID-19 patients. FDR control on pathway level (enrichment FDR corrected p-value < 0.05). B Lungs of COVID-19 patients show reduced abundance of several key kinases but prominent activation of STATs, typical mediators of inflammation (*Student’s t-test p-value < 0.05, ** Student’s t-test p-value < 0.01)