A proteomic profile of the healthy human placenta

Table 4 NaviCenta differential phenotype prediction based on DEP (Benjamini – Hochberg FDR correction) p-value including adj. Pval < 0.01 between maternal, middle, and fetal sub-anatomical regions and the proteins leading to each phenotype prediction

Phenotype	Mat-fet log2FC	pval	Gene Name	Mat-mid log2FC	pval		Mid-fet log2FC	pval	Gene Names
EC migration	0.28	5.94 e⁻²⁴	PLG	0.18	3.76 e⁻²⁸	PLG	0	1
Inflammatory response	− 0.26	5.91 e⁻²¹	IGHG4	0	1		− 0.31	2.30 e⁻³⁵	IGHG4
contraction	1	1.51 e⁻¹³	MYH11	1	5.41 e⁻³⁵	MYH11, TAGLN	− 0.33	3.13 e⁻²²	TAGLN
EC apoptosis	0.2	1.84 e⁻¹¹	BLVRB	0.15	2.39 e⁻¹³	BLVRB	0	1
EC proliferation	0.2	5.12 e⁻¹¹	BLVRB	0.15	5.83 e⁻¹³	BLVRB	0	1
Complement cascade	− 0.27	1.03 e⁻⁰⁸	IGHG4	0	1		− 0.31	3.94 e⁻¹⁹	IGHG4
chemotaxis	− 0.27	3.91 e⁻⁰⁸	IGHG4	0	1		− 0.31	5.30 e⁻¹⁸	IGHG4
Antigen clearance	0.41	0.003	IGHA1, IGLC3	− 0.05	0.070		0.63	2.22 e⁻¹¹	IGHA1
Destruction of pathogens	0.15	0.008	MPO	0.07	0.048		0	1
Ferritinophagy	0.2	0.453		− 0.14	0.001	FTL, FTH1	0	1
mRNA splicing	0	1		0.12	0.003	ACIN1	0	1

ISSN: 1559-0275