Fig. 1

Targeted proteomics accurately differentiates critically ill sepsis patients from healthy controls. In the upper section, t-SNE plots depict the separation between sepsis patients and healthy controls. Age- and sex-matched subjects plotted in 2D following dimensionality reduction of their respective proteomes by t-distributed stochastic neighbour embedding. Axes are dimensionless. The dimensionality reduction shows that based on plasma proteome, the two cohorts are distinct and easily separable. A Black dots represent ICU Day-1 patients and green dots represent healthy controls. B Orange dots represent ICU Day-3 patients and green dots represent healthy controls. C Proteins that feature selection identified as classifying proteins on both ICU Day-1 and Day-3 are shown in the Venn-diagram with overlap. Proteins in Red text were upregulated when compared to healthy controls, whereas proteins in Blue text were downregulated when compared to healthy controls