Fig. 2
From: Novel plasma protein biomarkers from critically ill sepsis patients
Significant temporal differences in plasma protein expression from sepsis patients. Box plots illustrating statistically significant differences between sepsis patients on ICU Day-1 versus ICU Day-3. The green shading illustrates healthy control protein expression (5–95% percentiles). Three ICU Day-1 classifying proteins significantly decreased in concentration by Day-3 (IL-10, CCL23, and TGFα1), and three ICU Day-3 classifying proteins significantly decreased in concentration by Day-3 (ST2, CNTN5, and ITGAV). Only one ICU Day-3 classifying protein was upregulated by ICU Day-3 (VSIG4). Median differences in protein concentrations were analyzed using Wilcoxon signed-rank tests, with P < 0.01 deemed statistically significant