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Table 1 Demographic and clinical data

From: Novel plasma protein biomarkers from critically ill sepsis patients

Variables

Healthy control subjects

Critically ill sepsis patients ICU day-1

Critically ill sepsis patients ICU day-3

P-value

n

15

15

15

1.000

Age in years, median (IQR)

55 (51–61)

56 (51–61)

56 (51–61)

0.448

Sex, female: male

9:6

9:6

9:6

1.000

MODS, median (IQR)

–

7 (5.0–8.0)

4 (3.5–7.0)

0.055

SOFA, median (IQR)

–

7 (5.0–9.0)

6 (3.5–7.0)

0.012*

Laboratory, median (IQR)

    

 Hemoglobin (g/L)

–

128.0 (109.0–147.0)

110.0 (87.0–120.0)

 < 0.001*

 White Blood Cell (109/L)

–

15.9 (11.5–22.7)

12.2 (7.3–14.3)

0.002*

 Neutrophils (109/L)

–

12.9 (8.6–15.7)

9.8 (5.4–11.9)

0.006*

 Lymphocytes (109/L)

–

1.2 (0.7–1.7)

1.2 (0.7–1.6)

0.528

 Platelets (109/L)

–

182.0 (107.0–259.0)

116.5 (79.0–189.0)

 < 0.001*

 Partial thromboplastin time (sec)

–

23.0 (21.0–29.0)

24.0 (22.0–27.0)

0.805

 International normalized ratio ([PTt/PTn]ISI)

–

1.0 (1.1–1.2)

1.0 (1.0–1.2)

0.313

 Creatinine (mmol/L)

–

79.0 (56.0–106.0)

54.5 (47.0–70.0)

0.065

 Lactate (mmol/L)

–

1.7 (0.9–3.2)

1.0 (0.9–1.2)

0.021*

Chest radiograph, n (%)

    

 Bilateral pneumonia

–

3 (20.0)

3 (20.0)

1.000

 Unilateral pneumonia

–

7 (46.7)

7 (46.7)

1.000

 Interstitial infiltrates

–

1 (6.7)

1 (6.7)

1.000

 Normal

–

4 (26.7)

4 (26.7)

1.000

 P/F Ratio, median (IQR)

–

164.0 (130.0–273.0)

188.0 (151.5–282.0)

0.321

Interventions, n (%)

    

 Antibiotics

–

15 (100.0)

15 (100.0)

1.000

 Antivirals

–

1 (6.7)

0 (0)

0.309

 Steroids

–

4 (26.7)

3 (20.0)

0.667

 Vasoactive medications

–

11 (73.3)

5 (33.3)

0.028*

 High Flow Nasal Cannula

–

0 (0)

1 (6.7)

0.309

 Noninvasive MV

–

2 (13.3)

0 (0)

0.143

 Invasive MV

–

15 (100.0)

12 (80.0)

0.068

Sepsis diagnosis, n (%)

    

 Suspected

–

10 (66.7)

–

–

 Confirmed

–

5 (33.3)

–

–

Comorbidities, n (%)

    

 Hypertension

–

9 (60.0)

–

–

 Diabetes

–

5 (33.3)

–

–

 Chronic Kidney Disease

–

1 (6.7)

–

–

 Coronary Artery Disease

–

0 (0)

–

–

 Chronic Heart Failure

–

1 (6.7)

–

–

 Cancer

–

1 (6.7)

–

–

 COPD

–

3 (20.0)

–

–

Baseline medications, n (%)

    

 Antiplatelet

–

6 (40.0)

–

–

 Anticoagulants

–

3 (20.0)

–

–

  1. *P < 0.005