Table 2 Median plasma expression of the top 25 classifying proteins, ICU Day-1
From: Novel plasma protein biomarkers from critically ill sepsis patients
Protein | Healthy controls | Sepsis day-1 | Change | P-value | Corrected P-value |
|---|---|---|---|---|---|
IL1RA | 15.38 (13.22–19.66) | 109.61 (83.37–142.19) | ↑ |  < 0.0001 | 0.0015 |
IL6 | 4.16 (3.33–4.66) | 169.24 (103.69–249.87) | ↑ |  < 0.0001 | 0.0015 |
FGF21 | 58.31 (30.80–71.63) | 498.68 (196.18–1735.47) | ↑ |  < 0.0001 | 0.0015 |
OPG | 2.95 (2.51–3.27) | 7.47 (5.29–10.82) | ↑ |  < 0.0001 | 0.0015 |
GDF15 | 3.90 (3.35–4.51) | 15.80 (12.49–30.66) | ↑ |  < 0.0001 | 0.0015 |
PRTN3 | 6.04 (4.79–7.27) | 22.72 (17.19–29.89) | ↑ |  < 0.0001 | 0.0015 |
UPAR | 6.56 (5.83–7.88) | 15.45 (11.52–30.35) | ↑ |  < 0.0001 | 0.0015 |
CTSD | 3.17 (2.67–3.42) | 6.75 (4.54–8.26) | ↑ |  < 0.0001 | 0.0015 |
DAG1 | 0.94 (0.88–1.01) | 1.34 (1.25–1.51) | ↑ |  < 0.0001 | 0.0015 |
TPP1 | 19.20 (17.12–20.23) | 32.29 (29.31–50.82) | ↑ |  < 0.0001 | 0.0015 |
IL10 | 8.31 (7.20–10.21) | 55.64 (32.67–98.75) | ↑ |  < 0.0001 | 0.0015 |
CCL23 | 628.15 (434.83–729.69) | 2299.48 (1512.89–3088.85) | ↑ |  < 0.0001 | 0.0015 |
CCL20 | 83.66 (62.37–101.75) | 570.22 (401.45–819.50) | ↑ |  < 0.0001 | 0.0015 |
CPA2 | 830.36 (591.96–906.17) | 162.32 (79.99–329.63) | ↓ |  < 0.0001 | 0.0015 |
GDF8 | 11.32 (9.56–16.78) | 2.84 (2.54–3.48) | ↓ |  < 0.0001 | 0.0015 |
NTRK3 | 107.56 (103.68–118.03) | 67.96 (54.14–79.73) | ↓ |  < 0.0001 | 0.0015 |
TGFα1 | 4.21 (4.04–5.21) | 9.86 (7.20–16.83) | ↑ |  < 0.0001 | 0.0015 |
WFDC2 | 374.19 (323.03–402.35) | 851.42 (706.71–1441.42) | ↑ |  < 0.0001 | 0.0015 |
CXCL13 | 134.98 (116.85–164.03) | 408.14 (300.90–493.60) | ↑ |  < 0.0001 | 0.0015 |
FGR | 2.85 (2.20–3.29) | 10.66 (8.25–15.97) | ↑ |  < 0.0001 | 0.0031 |
S100A11 | 10.24 (9.33–11.50) | 20.31 (16.91–22.85) | ↑ |  < 0.0001 | 0.0031 |
DSG4 | 5.77 (5.55–8.46) | 2.80 (2.04–3.83) | ↓ |  < 0.0001 | 0.0046 |
ELOA | 0.47 (0.46–0.57) | 1.02 (0.86–1.44) | ↑ |  < 0.0001 | 0.2090 |
NBN | 1.82 (1.59–2.56) | 4.89 (4.04–6.99) | ↑ |  < 0.0001 | 0.2090 |
SRP14 | 2.87 (2.43–3.63) | 9.93 (7.00–19.83) | ↑ |  < 0.0001 | 0.2090 |