Table 3 Median plasma concentration of the top 26 classifying proteins, ICU Day-3
From: Novel plasma protein biomarkers from critically ill sepsis patients
Protein | Healthy Controls | Sepsis Day-3 | Change | P-Value | Corrected P-Value |
|---|---|---|---|---|---|
TIMP1 | 17.58 (16.19–17.89) | 40.17 (27.01–54.83) | ↑ |  < 0.0001 | 0.0016 |
IL4RA | 2.08 (1.90–2.22) | 6.56 (3.63–8.15) | ↑ |  < 0.0001 | 0.0016 |
PRTN3 | 6.04 (4.79–7.27) | 21.62 (15.90–27.30) | ↑ |  < 0.0001 | 0.0016 |
UPAR | 6.56 (5.83–7.88) | 13.75 (11.00–27.40) | ↑ |  < 0.0001 | 0.0016 |
OPN | 11.85 (9.44–15.29) | 70.09 (43.82–78.26) | ↑ |  < 0.0001 | 0.0016 |
CHI3L1 | 6.60 (5.82–8.32) | 51.95 (27.92–68.54) | ↑ |  < 0.0001 | 0.0016 |
ST2 | 5.00 (4.48–5.47) | 44.50 (16.73–72.03) | ↑ |  < 0.0001 | 0.0016 |
TNFRSF10A | 5.33 (4.82–5.92) | 10.20 (8.48–14.02) | ↑ |  < 0.0001 | 0.0016 |
VSIG4 | 17.45 (14.62–19.43) | 94.61 (47.58–203.81) | ↑ |  < 0.0001 | 0.0016 |
ANGPT2 | 3.94 (3.37–4.07) | 9.90 (7.78–16.06) | ↑ |  < 0.0001 | 0.0016 |
NTproBNP | 7.94 (5.64–12.64) | 204.13 (66.21–817.22) | ↑ |  < 0.0001 | 0.0016 |
GDF8 | 11.32 (9.56–16.78) | 2.11 (1.61–2.88) | ↓ |  < 0.0001 | 0.0016 |
PVR | 218.29 (199.04–243.63) | 309.93 (285.85–389.24) | ↑ |  < 0.0001 | 0.0016 |
GCP5 | 14.86 (12.61–16.55) | 6.36 (4.92–8.15) | ↓ |  < 0.0001 | 0.0016 |
NTRK3 | 107.56 (103.68–118.03) | 62.54 (49.32–70.67) | ↓ |  < 0.0001 | 0.0016 |
ITGAV | 26.03 (24.62–28.56) | 15.99 (11.29–17.31) | ↓ |  < 0.0001 | 0.0016 |
WFDC2 | 374.19 (323.03–402.35) | 985.66 (767.97–1208.01) | ↑ |  < 0.0001 | 0.0016 |
CXCL13 | 134.98 (116.85–164.03) | 446.75 (279.79–716.64) | ↑ |  < 0.0001 | 0.0016 |
GALNT7 | 16.62 (14.71–18.76) | 9.52 (7.20–10.56) | ↓ |  < 0.0001 | 0.0016 |
KIM1 | 110.58 (93.33–161.57) | 590.88 (461.90–854.33) | ↑ |  < 0.0001 | 0.0032 |
TNFR1 | 19.92 (17.61–23.92) | 49.37 (33.71–86.61) | ↑ |  < 0.0001 | 0.0032 |
SPINK1 | 7.53 (6.75–9.08) | 75.56 (22.32–239.37) | ↑ |  < 0.0001 | 0.0032 |
ASGR1 | 10.53 (9.60–11.96) | 32.71 (20.44–42.41) | ↑ |  < 0.0001 | 0.0032 |
CNTN5 | 24.25 (21.81–25.63) | 8.72 (6.28–10.84) | ↓ |  < 0.0001 | 0.0032 |
PLXDC1 | 7.34 (6.79–8.14) | 4.71 (3.93–5.21) | ↓ |  < 0.0001 | 0.2174 |
NPM1 | 11.89 (8.82–13.24) | 30.37 (22.76–38.50) | ↑ |  < 0.0001 | 0.7839 |