Fig. 4

The presence of a luminol-oxidase activity in the plasma of COVID-19 and ICU Acute Respiratory Distress Syndrome patients (ICU-ARDS) compared to Normal Human Plasma (NHP). A One microlitre (1 µL) of a representative set of COVID-19 plasma was spotted onto PVDF alongside a specifically selected set of ICU-ARDS plasma (positive control) and two sets of representative NHP plasma (negative control) ECL dot blots. Cytochrome c from 0 to 100 ng/µL served as a detection standard. Arrows show the sample lanes; B Quantile boxplot of the intensity of luminol oxidase activity from the complete set of COVID-19, ICU-ARDS and NHP plasma samples in the study. The results from the two independent batches of normal that showed similar results were combined for graphic and statistical analysis. Significant difference by the Tukey Kramer Honestly Significant Difference (HSD) test at the p ≤ 0.05 level are shown by lower case letters