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Fig. 5 | Clinical Proteomics

Fig. 5

From: Mitochondria and cytochrome components released into the plasma of severe COVID-19 and ICU acute respiratory distress syndrome patients

Fig. 5

A cartoon summary of the mitochondrial proteins and enzyme activities discovered by LC–ESI–MS/MS from COVID-19 versus ICU and NHP sample populations. The SARS-CoV-2 spike protein is apparently cleaved by extracellular TMPRSS5 to gain entry via ACE2 and is unpacked in the cytosol releasing the spike and triggering expression of VDAC that releases the contents of the mitochondria including cytochrome, electron transport complex, ribosomal and others components such as MRPL, MT-ND, MT-COX, NDUF, CYB5RL and CYTB (see Table 4). Created with BioRender.com

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Clinical Proteomics

ISSN: 1559-0275