Mitochondria and cytochrome components released into the plasma of severe COVID-19 and ICU acute respiratory distress syndrome patients

Table 3 A comparison of corrected mean observation frequency of tryptic (TRYP) versus phosphotryptic (STYP) mitochondrial and cytochrome proteins per gene symbol from SEQUEST across COVID-19, ICU-ARDS and Normal Human Plasma (NHP)

Gene_Symbol	COVID-19			COVID-19			ICU-ARDS			ICU-ARDS			NHP	NHP	OIT
Gene_Symbol	TRYP	Delta	χ2	STYP	Delta	χ2	TRYP	Delta	χ2	STYP	Delta	χ2	TRYP	STYP	TRYP	STYP
MRPL37	760	544	1364*	238	80	40*	398	182	153*	142	-16	2	216	158	6	23
L2HGDH	672	261	165*	932	247	89*	562	151	55*	864	179	47*	411	685	5	4
ACSS3	471	77	15*				547	153	59*				394		36
CYP3A7-CYP3A51P	223	93	66*				210	80	49*				130		6
ATP5A1	219	65	27*	116	32	12*	182	28	5	121	37	16*	154	84	21	5
AASS	206	44	12*	417	84	21*	211	49	15*	539	206	127*	162	333	21	22
POLRMT	201	46	14*				196	41	11*				155		31
MRPS16	200	143	353*	277	146	161*	157	100	172*	292	161	196*	57	131	2	18
MRPS27	196	59	25*	93	51	60*	211	74	40*	64	22	11*	137	42	6	13
CYP3A4	192	117	180*	77	30	19*	158	83	91*	97	50	52*	75	47	8	10
CYP3A43/CYP3A4	187	116	187*	106	37	20*	154	83	96*	135	66	62*	71	69	8	15
ACAD9	186	95	98*	253	116	98*	179	88	84*	169	32	7	91	137	25	9
GUF1	177	61	32*				157	41	14*				116		22
CYP3A43	175	91	97*	65	23	12*	143	59	41*	56	14	5	84	42	8	9
ACSF3	173	45	16*				117	-11	1				128		18
GPAT2	169	103	158*				63	-3	0				66		9
CYP17A1	166	43	15*				134	11	1				123		10
COA6	163	78	71*				130	45	24*				85		8
NDUFS1	163	39	12*	67	20	8	133	9	1	52	5	1	124	47	19	10
ACSM5	158	62	40*				133	37	14*				96		13
ND5	157	149	2467*				118	110	1344*				8		0
BDH1	155	50	24*	242	115	103*	123	18	3	183	56	25*	105	127	6	7
CYB561D1	152	108	259*	13	8	11*	203	159	562*	9	4	3	44	5	0	0
MCCC1	152	52	27*				165	65	42*				100		20
GPD2	150	34	10*				125	9	1				116		10
DHODH	148	39	14*	118	57	52*	94	-15	2	35	-26	11*	109	61	14	1
IMMT	124	52	37*				153	81	90*				72		58
LOC101060817	122	85	190*				81	44	51*				37		1
TIMM21	119	33	13*				109	23	6				86		7
MIPEP	115	29	10*				81	-5	0				86		17
ACAD8	114	35	15*	194	90	77*	111	32	13*	176	72	49*	79	104	4	10
DLD	114	32	12*				108	26	8				82		15
CYP1A1	107	39	22*				76	8	1				68		4
CYP21A2	107	50	43*	18	13	28*	89	32	18*	6	1	0	57	5	27	0
CYP39A1	107	55	57*				93	41	32*				52		3
GCSH	103	79	250*	47	32	64*	62	38	58*	24	9	5	24	15	1	10
CYP26B1	99	40	27*				67	8	1				59		11

The observation frequency was computed after correcting for the number of MS/MS spectra in each treatment with precursor intensity ≥ E3 detector counts. The SQL SERVER accession descriptions were queried by “mitochondria” or “cytochrome”. The difference (Delta) and Chi Square value χ2 with respect to NHP are shown. The asterisk * indicates a significant increase in observation frequency by the Chi Square test in the COVID-19 or ICU-ARDS plasma compared to the Normal Human Plasma (NHP) with χ2 ≥ 10, p ≤ 0.01. The chance that the observation frequency of the mitochondrial and cytochrome gene symbols shown are similar between COVID-19, ICU-ARDS and NHP by One Way ANOVA was p ≤ 0.003

ISSN: 1559-0275