Fig. 3

Differential expressed proteins (DEPs) in serum samples and GO and KEGG analysis for DEPs among UC, CD and HC groups. A–B Volcano plots showing the DEPs between CD as well as UC and HC. Orange and green plots represent up and down-regulated proteins. C Heatmap showing the GO biological process term enriched by the DEPs between IBD and HC. * indicates P < 0.05. D KEGG enrichments for these DEPs. * indicates P < 0.05. E Several acute-phase proteins are depicted by a z-score pseudocolor scale among groups. CRP: C reaction protein; ORM1: orosomucoid 1; ORM2: orosomucoid 2; SAA1: serum amyloid A1; SAA2: serum amyloid A2; SAA2-SAA4: serum amyloid A2-serum amyloid A4; CP: ceruloplasmin; HP: haptoglobin; LBP: lipopolysaccharide binding protein. The color of the bar indicates the z-score (blue, negative z-score; red, positive z-score). Comparation of aforementioned acute-phase proteins between UC as well as CD and HC are depicted by a -log10 (P value) pseudocolor scale. * indicates P < 0.05. F Box plots represent HBA1 and FGA abundance levels in the serum samples as markers for anemia and thromboembolic disease between CD as well as UC and HC. The inter-quartile ranges are shown. P < 0.05 is considered as significant (two-sided t test)