Fig. 5

Serum proteome and fecal metaproteome analyses among UC_F, UC_NF, CD_F, CD_NF, HC_F, and HC_NF groups. A The impacts of obesity on the serum proteome in HC. Volcano plot showing the DEPs between HC_F and HC_NF. B The impacts of obesity on the serum proteome in CD patients. Volcano plot showing the DEPs between CD_F and CD_NF. C The impacts of obesity on the serum proteome in UC patients. Volcano plot showing the DEPs between CC_F and UC_NF. Orange and green plots represent up and down-regulated proteins. D Heatmap showing the GO terms and pathways enriched by altered serum proteins by overweight/obesity in the IBD patients using Metascape. Significant GO terms and pathways are shown. * indicates P < 0.05. E Comparison of CRP, SAA1, ORM1, and LBP levels in serum sample among six groups. F Alpha diversity was determined by Chao1 richness. G LEfSe analysis for HC_F vs. HC_NF and UC_F vs. UC_NF. Box plot shows median (middle line) bounded by minimum, first quartile (lower border of the box), third quartile (upper border of the box) and maximum. P < 0.05 is considered as significant (two-sided t test)