Fig. 4
From: Discovery of novel glioma serum biomarkers by proximity extension assay
Combination of GFAP and FABP4 for discriminating gliomas (red circles) from meningiomas (blue dots) Anaplastic astrocytomas (red crossed diamonds) and anaplastic oligodendrogliomas (red double diamonds) are also shown. A: The vertical dashed line shows GFAP cut-ff at 100% specificity for gliomas and the horizontal dashed line shows FABP4 cut-off at 100% specificity for meningiomas. This model also aggregates the glioma cases by sub-type with glioblastomas having high GFAP, meningioma having low GFAP and high FABP4, while anaplastic astrocytomas and oligodendrogliomas display both low FABP4 and low GFAP [9, 10]. At 100% specificity (correct prediction of all 20 meningiomas) the sensitivity (correct prediction of gliomas) was 25/30 or 83%. B: Classification using logistic regression. We correctly classified 18/20 meningiomas (specificity of 90%) and 28/30 gliomas (sensitivity of 93%). The misclassified cases (two gliomas and two meningiomas) are circled