Table 2 Literature analysis of thirty-nine validated urinary biomarkers

P09237

MMP7

Matrilysin

Up

 × 

 × 

IgA, kidney fibrosis

Colon cancer, cervical cancer, gastric cancer, bladder cancer, ovarian cancer, oral verrucous and squamous cell cancer, head and neck squamous cell carcinomas

Q13938

CAPS

Calcyphosin

Up

 × 

 × 

 × 

Pediatric primitive neuroectodermal tumors, breast cancer, lung cancer

P15907

ST6GAL1

Beta-galactoside alpha-2,6-sialyltransferase 1

Up

 × 

√

 × 

Hepatocellular carcinoma, gastric cancer, colorectal cancer

P30086

PEBP1

Phosphatidylethanolamine-binding protein 1

Up

 × 

 × 

Prostate cancer, ovarian cancer, clear cell renal cell carcinoma

Bladder cancer, pancreatic cancer, lung adenocarcinoma, hepatocellular carcinoma

Q07075

ENPEP

Glutamyl aminopeptidase

Up

 × 

 × 

Familial Parkinson's disease

Colorectal cancer, breast cancer

Q24JP5

TMEM132A

Transmembrane protein 132A

Up

 × 

 × 

 × 

 × 

Q9H6S3

EPS8L2

Epidermal growth factor receptor kinase substrate 8-like protein 2

Up

 × 

 × 

Proliferative lupus nephritis, renal cell carcinoma

Endometrial carcinoma

P01911

HLA-DRB1

HLA class II histocompatibility antigen, DRB1 beta chain

Up

 × 

 × 

Renal allograft rejection

 × 

P01009

SERPINA1

Alpha-1-antitrypsin

Up

 × 

 × 

Preeclampsia, primary nephrotic syndrome, respiratory pathologies, bladder cancer, prostate cancer, morquio syndrome, hypertension

Bladder cancer, oral cancer, pancreatic cancer, non-small-cell lung cancer

P02671

FGA

Fibrinogen alpha chain

Up

 × 

 × 

Prostate cancer, bladder cancer, renal allograft rejection

Prostate cancer, bladder cancer

O14745

SLC9A3R1

Na( +)/H( +) exchange regulatory cofactor NHE-RF1

Up

 × 

 × 

 × 

Hepatocellular carcinoma

Q10588

BST1

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Up

 × 

 × 

Polycystic and other chronic kidney diseases, chronic lung allograft dysfunction

Prostate cancer

O75309

CDH16

Cadherin-16

Up

 × 

 × 

Sepsis-induced acute kidney injury

Papillary thyroid cancer, lung adenocarcinoma

P31997

CEACAM8

Carcinoembryonic antigen-related cell adhesion molecule 8

Up

 × 

 × 

 × 

Oral squamous cell carcinoma, non-small cell lung cancer, gastric cancer

Q9UKK9

NUDT5

ADP-sugar pyrophosphatase

Up

 × 

 × 

 × 

Breast cancer, colon cancer

Q9UN74

PCDHA4

Protocadherin alpha-4

Up

√

 × 

 × 

Cervical cancer

Q13705

ACVR2B

Activin receptor type-2B

Down

 × 

√

 × 

Colorectal cancer

Q6FHJ7

SFRP4

Secreted frizzled-related protein 4

Down

 × 

 × 

 × 

Endometrial carcinoma, bladder cancer, gastric cancer, colon cancer

O43278

SPINT1

Kunitz-type protease inhibitor 1

Down

 × 

 × 

Urothelial carcinoma

Prostate adenocarcinoma, cervical cancer,

Endometrial carcinoma, CLL, pancreatic ductal adenocarcinoma

O43291

SPINT2

Kunitz-type protease inhibitor 2

Down

 × 

 × 

 × 

Cervical cancer, endometrial carcinoma, breast cancer, prostate cancer

P08174

CD55

Complement decay-accelerating factor

Down

 × 

 × 

Respiratory pathologies, prostate cancer

Colon cancer, primary gallbladder carcinoma, bladder cancer

P09131

SLC10A3

P3 protein

Down

 × 

 × 

 × 

 × 

P09486

SPARC

SPARC

Down

 × 

 × 

Clear cell renal cell carcinoma, urinary bladder cancer

Rectal cancer, non-small-cell lung cancer, pancreatic cancer, gastric cancer, hypopharyngeal cancer, colon cancer, diffuse large B-cell lymphoma, breast cancer

P13598

ICAM2

Intercellular adhesion molecule 2

Down

 × 

 × 

 × 

Lung cancer

P15151

PVR

Poliovirus receptor

Down

 × 

 × 

 × 

Multiple myeloma, bladder cancer

P16112

ACAN

Aggrecan core protein

Down

 × 

 × 

 × 

Gastric cancer, breast cancer

P19022

CDH2

Cadherin-2

Down

 × 

 × 

Respiratory pathologies, diabetic nephropathy

Malignant bone and soft tissue tumors, ductal carcinoma, glioblastoma, papillary thyroid carcinoma

P19652

ORM2

Alpha-1-acid glycoprotein 2

Down

 × 

 × 

Rheumatoid arthritis, adult-onset Still's disease

colorectal cancer, cervical cancer, cholangiocarcinoma, papillary thyroid carcinoma, liver cancer

P20138

CD33

Myeloid cell surface antigen CD33

Down

 × 

 × 

 × 

Colorectal cancer, AML

P30530

AXL

Tyrosine-protein kinase receptor UFO

Down

√

 × 

 × 

Osteosarcoma, melanoma, esophageal adenocarcinoma, non-small cell lung cancer, colorectal adenocarcinoma, Wilms' tumor

Q15043

SLC39A14

Metal cation symporter ZIP14

Down

 × 

 × 

 × 

Colorectal cancer, prostate cancer, breast cancer

Q9HBB8

CDHR5

Cadherin-related family member 5

Down

 × 

 × 

Autism

Hepatocellular carcinoma, clear cell renal cell carcinoma, pancreatic ductal adenocarcinoma

Q9NU53

GINM1

Glycoprotein integral membrane protein 1

Down

 × 

 × 

Bladder carcinoma

Bladder carcinoma

Q9ULK6

RNF150

RING finger protein 150

Down

 × 

 × 

 × 

 × 

Q9Y4C0

NRXN3

Neurexin-3

Down

 × 

 × 

 × 

Glioblastoma

O75339

CILP

Cartilage intermediate layer protein 1

Down

 × 

 × 

Cartilage matrix turnover

Bladder cancer

Q9H6X2

ANTXR1

Anthrax toxin receptor 1

Down

 × 

 × 

 × 

Angiosarcoma, gastric cancer, colorectal cancer, lung cancer

P43490

NAMPT

Nicotinamide phosphoribosyltransferase

Down

√

 × 

 × 

Glioblastoma, bladder cancer, breast cancer, prostate cancer, basal cell carcinomas, breast invasive ductal carcinoma

Q9BXN2

CLEC7A

C-type lectin domain family 7 member A

Down

 × 

 × 

 × 

Clear cell renal cell carcinoma, AML