Proteomic signature associated with chronic kidney disease (CKD) progression identified by data-independent acquisition mass spectrometry

Table 2 List of protein biomarkers identified using Boruta Feature Selection with their log2 fold change, median permutation importance; p-values and cumulative AUC shown

Protein	Name	Log2 fold change	Median importance	Differential expression p-value	Differential expression Adj p-value	Cumulative AUC
P50991	*CCT4*	1.92	12.3	< 0.001	0.008	0.67
P43652	AFM	− 0.26	7.955	< 0.001	0.001	0.684
Q86WR0	CCDC25	2.349	8.078	0.001	0.043	0.688
P02766	TTR	− 0.309	7.403	< 0.001	0.002	0.701
Q01581	HMGCS1	0.128	7.071	0.734	0.908	0.704
P13671	C6	− 0.137	6.177	0.001	0.043	0.711
Q8NC51	SERBP1	0.849	6.902	0.018	0.153	0.711
P04220	IGHM	2.28	5.791	< 0.001	0.007	0.746
Q99969	RARRES2	− 2.464	5.4	< 0.001	0.001	0.749
Q02790	FKBP4	− 1.389	4.687	0.004	0.074	0.759
P28074	*PSMB5*	− 2.63	4.624	< 0.001	0.007	0.76
P13667	PDIA4	0.784	4.575	0.035	0.199	0.762
P08670	*VIM*	− 1.91	4.236	0.004	0.076	0.765
P21810	BGN	1.647	4.193	< 0.001	0.02	0.777
P02745	*C1QA*	− 0.175	4.155	0.003	0.07	0.78
P20851	*C4BPB*	− 0.526	4.114	0.032	0.194	0.786
P40227	*CCT6A*	1.277	3.888	0.086	0.31	0.786
P52566	ARHGDIB	0.555	3.656	0.18	0.458	0.787
Q15746	MYLK	− 1.492	3.709	0.004	0.07	0.787
P61764	STXBP1	− 2.397	3.52	< 0.001	0.02	0.793
P20618	*PSMB1*	0.17	3.417	0.825	0.955	0.794
Q96HR3	MED30	0.524	3.33	0.123	0.369	0.795
P29622	SERPINA4	− 0.159	2.808	0.001	0.043	0.804
P22105	TNXB	0.284	3.05	0.371	0.642	0.806
P31943	HNRNPH1	1.624	2.99	0.014	0.135	0.806

The eight proteins that were found to be part of a specifical biological pathway after functional enrichment analysis have been italicized

ISSN: 1559-0275