Table 3 Functional annotation clustering of the proteins showing greater than 1.5-fold differential expression level between CRC patients and healthy controls. The gene ontology (GO) classes with p-value < 0.05 and false discovery rate (FDR) < 0.05 were considered significant.
GO Accession | Term | Involved proteins | p-value | FDR |
|---|---|---|---|
Non-Metastatic CRC Group | Â | Â | |
GO:0006958 | Complement activation, classical pathway | C1qC, IGHG4 and C4A | < 0.001 | 0.0427 |
GO:0045087 | Innate immune response | C1qC, IGHG4 and C4A | 0.013 | 0.3363 |
GO:0070527 | Platelet aggregation | HBB and FN | 0.014 | 0.3363 |
GO:0042742 | Defense response to bacterium | IGHG4, PBP | 0.070 | 1.000 |
Metastatic CRC group | Â | Â | |
GO:0006953 | Acute-phase response | A1AT and AGP1, FN and HP | < 0.001 | 0.0001 |
GO:0006958 | Complement activation, classical pathway | C4B, IGHG4, C4A and C9 | < 0.001 | 0.0017 |
GO:0006954 | Inflammatory response | C4B, C4A, AGP1 and S100A8 | < 0.001 | 0.0377 |
GO:0010951 | Negative regulation of endopeptidase activity | A1AT, C4B and C4A | 0.003 | 0.0594 |
GO:0045087 | Innate immune response | C4B, IGHG4, C4A and S100A8 | 0.003 | 0.0594 |
GO:2000427 | Positive regulation of apoptotic cell clearance | C4B and C4A | 0.003 | 0.0594 |
GO:0042742 | Defense response to bacterium | IGHG4, HP and S100A8 | 0.006 | 0.0979 |
GO:0002526 | Acute inflammatory response | HP and S100A8 | 0.009 | 0.1251 |
GO:0006956 | Complement activation | C4B and C4A | 0.010 | 0.1251 |
GO:0004866 | Endopeptidase inhibitor activity | C4B and C4A | 0.023 | 0.8819 |
GO:0002020 | Protease binding | A1AT and FN | 0.056 | 1.0000 |