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Table 3 Association between differences in diet-related plasma proteins and differences in lipoprotein concentrations in the OmniHeart Triala

From: Associations of circulating proteins with lipoprotein profiles: proteomic analyses from the OmniHeart randomized trial and the Atherosclerosis Risk in Communities (ARIC) Study

   

HDL-C

(mmol/L)

Triglyceride

(mmol/L)

non-HDL-C (mmol/L)

TC:HDL-C ratio

Name of the protein

Uniprot ID

Entrezgene

symbol

\(\beta\)

P-value

\(\beta\)

P-value

\(\beta\)

P-value

\(\beta\)

P-value

Protein-rich vs. carbohydrate-rich dietary pattern (reference) (n = 6)

Apolipoprotein M

O95445

APOM

0.29

4.86 × 10− 6

—

—

—

—

—

—

Afamin

P43652

AFM

0.48

1.96 × 10− 6

—

—

—

—

—

—

Collagen alpha-3(VI) chain

P12111

COL6A3

—

—

1.30

2.53 × 10− 4

1.19

4.02 × 10− 5

—

—

Chitinase-3-like protein 1

P36222

CHI3L1

—

—

0.34

2.79 × 10− 4

—

—

—

—

Inhibin beta A chain

P08476

INHBA

—

—

0.44

1.20 × 10− 4

—

—

—

—

Palmitoleoyl-protein carboxylesterase NOTUM

Q6P988

NOTUM

—

—

0.38

6.46 × 10− 5

—

—

—

—

Unsaturated fat-rich vs. carbohydrate-rich dietary pattern (reference) (n = 4)

Cathelicidin antimicrobial peptide

P49913

CAMP

—

—

0.86

4.96 × 10− 7

0.65

1.12 × 10− 6

—

—

Guanylate-binding protein 2

P32456

GBP2

—

—

—

—

—

—

0.36

1.14 × 10− 5

COP9 signalosome complex subunit 7b

Q9H9Q2

COPS7B

—

—

—

—

0.49

1.38 × 10− 5

—

—

Sodium-coupled monocarboxylate transporter 1

Q8N695

SLC5A8

—

—

—

—

—

—

0.61

7.89 × 10− 8

Protein-rich vs. unsaturated fat-rich dietary pattern (reference) (n = 1)

Sodium-coupled monocarboxylate transporter 1

Q8N695

SLC5A8

-0.24

1.26 × 10− 10

—

—

—

—

—

—

  1. a All diet comparisons lowered high-density lipoprotein (HDL)-cholesterol (C), triglycerides, non-HDL-C and the ratio of total cholesterol and HDL-C. The unsaturated fat-rich vs. carbohydrate-rich dietary patterns increased HDL-C concentration, and the protein-rich vs. unsaturated fat-rich dietary patterns found no difference in non-HDL-C (Additional file 2: Table S1). \(\beta\) coefficients and P-values were calculated from linear regression models which used differences in proteins (exposure) and differences in lipoproteins at the end of the intervention period for each diet comparison (response). For the protein-rich vs. carbohydrate-rich dietary patterns, we used the Bonferroni threshold of 5.56 × 10− 4 (0.05/18 diet-related proteins/5 lipoprotein outcomes [low-density lipoprotein-C, HDL-C, triglycerides, total cholesterol, non-HDL-C, ratio of total cholesterol to HDL-C]). For unsaturated fat-rich vs. carbohydrate-rich dietary patterns, we used 2.99 × 10− 5 (0.05/335 diet-related proteins/5 lipoprotein outcomes). For protein-rich vs. unsaturated fat-rich dietary patterns, we used 2.51 × 10− 5 (0.05/398 diet-related proteins/5 lipoprotein outcomes). Diet-related proteins significantly associated with lipoprotein outcomes that had statistically significant mediation are presented. No diet-related protein was significantly associated low-density lipoprotein-C
  2. — indicates that there was no significant association between the diet-related protein and lipoprotein outcome
  3. TC, total cholesterol