Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy

Table 2 Comparisons of AUC between candidate EP vs. non-EP biomarkers identified in the proteomics discovery cohort (N = 48)

Gene Name	Protein Description	AUC	Std. Error	95% Confidence Interval		P-value
PAEP	Glycodelin	0.898	0.046	0.808	0.989	< 0.0001
PSG9	Pregnancy-specific beta-1-glycoprotein 9	0.785	0.077	0.633	0.937	0.001
PSG3	Pregnancy-specific beta-1-glycoprotein 3	0.783	0.083	0.620	0.946	0.002
CGB	Choriogonadotropin subunit beta	0.779	0.083	0.617	0.942	0.002
ISM2	Isthmin-2	0.775	0.080	0.619	0.932	0.002
PSG2	Pregnancy-specific beta-1-glycoprotein 2	0.774	0.073	0.632	0.917	0.002
CGA	Glycoprotein hormones alpha chain	0.766	0.084	0.600	0.931	0.003
PSG1	Pregnancy-specific beta-1-glycoprotein 1	0.764	0.083	0.602	0.926	0.003
NOTUM	Protein notum homolog	0.703	0.084	0.539	0.867	0.023
PAPPA	Pappalysin-1	0.681	0.088	0.509	0.852	0.043
PSG11	Pregnancy-specific beta-1-glycoprotein 11	0.666	0.088	0.494	0.838	0.063
ADAM12	Disintegrin and metalloproteinase domain-containing protein 12	0.664	0.084	0.499	0.829	0.066

ISSN: 1559-0275