Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy

Table 4 Multivariable logistic regression models for EP vs. non-EP (N = 74)

Predictors	Coefficient^a	Std. Error	z	P>\|z\|	95% Confidence Interval
Model 1: NOTUM + PAEP + PAPPA + PSG2
NOTUM	-1.62	0.865	-1.87	0.061	-3.316	0.076
PAEP	-1.573	0.535	-2.94	0.003	-2.622	-0.524
PAPPA	-0.03	0.197	-0.15	0.878	-0.417	0.356
PSG2	0.097	0.52	0.19	0.853	-0.923	1.117
Constant	13.282	4.562	2.91	0.004	4.341	22.223
Model 2: ISM2 + PAEP + PAPPA + PSG2
ISM2	-0.31	0.386	-0.8	0.422	-1.066	0.447
PAEP	-1.349	0.444	-3.04	0.002	-2.22	-0.478
PAPPA	-0.109	0.174	-0.63	0.531	-0.45	0.232
PSG2	-0.338	0.476	-0.71	0.477	-1.27	0.594
Constant	8.312	2.881	2.89	0.004	2.665	13.958
Model 3: ISM2 + PAEP + PAPPA + ADAM12
ISM2	-0.336	0.421	-0.8	0.424	-1.161	0.488
PAEP	-1.349	0.443	-3.05	0.002	-2.216	-0.482
PAPPA	-0.141	0.163	-0.86	0.387	-0.462	0.179
ADAM12	-0.236	0.503	-0.47	0.639	-1.223	0.75
Constant	8.43	2.944	2.86	0.004	2.66	14.2
Model 4: NOTUM + PAEP + PAPPA + ADAM12
NOTUM	-2.201	1.159	-1.9	0.058	-4.474	0.071
PAEP	-1.739	0.622	-2.8	0.005	-2.959	-0.52
PAPPA	-0.128	0.232	-0.55	0.58	-0.584	0.327
ADAM12	0.62	0.772	0.8	0.422	-0.892	2.133
Constant	14.289	5.071	2.82	0.005	4.351	24.227

^aCoefficients and constants are used to calculate risk scores for each individual patient

ISSN: 1559-0275