Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy

Table 6 Comparisons of AUC between each logistic model with single predictors versus each multivariable logistic model predicting EP vs. non-EP (N = 74)

Predictors	AUC	Std. Error	95% Confidence Interval		Model 1: P-value^a	Model 2: P-value^a	Model 3: P-value^a	Model 4: P-value^a
Model 1: NOTUM + PAEP + PAPPA + PSG2	0.986	0.010	0.967	1.000	Reference	N/A	N/A	N/A
Model 2: ISM2 + PAEP + PAPPA + PSG2	0.980	0.012	0.957	1.000	N/A	Reference	N/A	N/A
Model 3: ISM2 + PAEP + PAPPA + ADAM12	0.980	0.012	0.957	1.000	N/A	N/A	Reference	N/A
Model 4: NOTUM + PAEP + PAPPA + ADAM12	0.987	0.010	0.968	1.000	N/A	N/A	N/A	Reference
ISM2	0.941	0.029	0.885	0.997	0.051	0.071	0.078	0.046
NOTUM	0.939	0.029	0.882	0.996	0.049	0.073	0.078	0.044
PSG8/1	0.936	0.030	0.878	0.993	0.038	0.056	0.061	0.034
PSG2	0.935	0.030	0.877	0.993	0.031	0.035	0.039	0.027
PSG1	0.931	0.031	0.870	0.991	0.030	0.041	0.044	0.027
ADAM12	0.916	0.034	0.849	0.982	0.018	0.022	0.023	0.017
PAEP	0.915	0.042	0.832	0.998	0.081	0.106	0.104	0.081
PSG6/9	0.907	0.035	0.838	0.976	0.009	0.011	0.011	0.008
PSG11	0.897	0.036	0.826	0.968	0.004	0.004	0.005	0.004
PAPPA	0.894	0.039	0.817	0.970	0.012	0.013	0.013	0.011
CGA	0.865	0.043	0.780	0.949	0.003	0.004	0.004	0.003
PSG9	0.857	0.045	0.769	0.945	0.002	0.002	0.002	0.002
PSG3	0.825	0.053	0.722	0.928	0.001	0.002	0.002	0.001
CGB	0.820	0.049	0.723	0.916	0.000	0.001	0.001	0.000

ISSN: 1559-0275