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Fig. 2 | Clinical Proteomics

Fig. 2

From: Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization

Fig. 2

Standard proteomic analysis. Proteins differentially upregulated in PPGLs relative to control tissues (NAM). Volcano plots (protein expression fold-change plotted against the statistical significance) separately for each PPGL group (cluster 1, cluster 2, and unassigned PPGLs). Colored spots indicate the proteins upregulated (threshold 4-fold, p-val 0.05) in each tumor group than in the control tissues (NAM). Gene names for the corresponding proteins are shown for clarity, and only for the proteins discussed further. Upregulated proteins detected in tumors but absent in NAM could not be plotted (due to the missing fold-change and significance values), those of interest are therefore listed in the inset boxes. MCAM, melanoma cell adhesion molecule (CD146); L1CAM, neural cell adhesion molecule L1 (CD171); SHMT2, serine hydroxymethyl transferase 2; ACE, angiotensin-converting enzyme; ARG2, arginase 2; ENPP2, ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (autotaxin); ATP8A1, phospholipid-transporting ATPase IA; TMEM30A, cell cycle control protein 50 A

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Clinical Proteomics

ISSN: 1559-0275