Table 2 Candidate phosphosite signature (n = 78) for prediction of sunitinib treatment outcome in RCC

Phosphosites upregulated in primary resistant patients

 Uniquely upregulated in resistant tumors

BCAR3_Y117

n/a

n/a

EIF4A2_Y251

n/a

n/a

NOP58_Y272

n/a

n/a

GDI1_Y93

n/a

n/a

 Differentially upregulated (not unique)

ZNF618_T647

0.004

22.2

CD247_Y141

0.008

15.2

MYOF_Y416

0.009

22.0

CD247_Y110

0.013

12.2

APBB1IP_Y380

0.018

2.8

PTTG1IP_Y144

0.018

3.1

ATP5PD_Y126

0.020

7.3

NCS1_Y97

0.022

9.4

DOK3_Y342

0.023

6.3

CLDN1_Y210

0.025

6.0

STAT4_Y693

0.029

4.2

PRMT1_Y263

0.030

3.3

NPHP3_Y467

0.031

10.5

ALOX5_Y95

0.033

5.3

PKP2_Y10

0.034

11.0

SERINC5_Y345

0.038

9.8

ACTN4_Y265

0.045

4.4

SAMHD1_Y315

0.047

3.9

Phosphosites upregulated in sensitive patients

 Uniquely upregulated in sensitive tumors

PEAK1_Y635

n/a

n/a

EPHA2_Y575

n/a

n/a

NCK2_Y110

n/a

n/a

TLN1_Y26

n/a

n/a

EGFR_Y1138

n/a

n/a

CTNND1_Y174

n/a

n/a

CDK2_S90

n/a

n/a

NSFL1C_Y167

n/a

n/a

FLNA_Y346

n/a

n/a

MTMR10_Y708

n/a

n/a

AKR1A1_Y50

n/a

n/a

BCAR1_Y304

n/a

n/a

GRASP_Y94

n/a

n/a

TUBA1B_Y357

n/a

n/a

TNS2_Y581

n/a

n/a

ARAP1_Y747

n/a

n/a

SHANK2_Y321

n/a

n/a

GSTA1_Y132

n/a

n/a

PYGL_Y170

n/a

n/a

NIPSNAP1_Y148

n/a

n/a

SDHA_Y523

n/a

n/a

FBP2_Y216

n/a

n/a

HINT2_Y146

n/a

n/a

KIT_Y932

n/a

n/a

LRRK2_Y2023

n/a

n/a

CARS1_Y73

n/a

n/a

ALB_Y164

n/a

n/a

NPEPL_Y229

n/a

n/a

CAV1_Y11

n/a

n/a

NDUFB9_Y118

n/a

n/a

SSBP1_Y119

n/a

n/a

PDK1_Y136

n/a

n/a

DNAJC13_Y1641

n/a

n/a

F2R_Y420

n/a

n/a

STAT5A_Y98

n/a

n/a

 Differentially upregulated (not unique)

HSPB1_S15

0.001

− 6.9

PPA2_Y241

0.004

− 4.8

CAVIN1_Y308

0.005

− 8.6

PTK2_Y879

0.007

− 3.1

MYL6_Y86

0.009

− 15.5

NAXD_Y85

0.012

− 4.5

MAPK1_Y187

0.015

− 3.8

GSK3A_Y279

0.023

− 2.3

TNK2_Y859

0.027

− 16.9

LPP_Y295

0.028

− 3.4

PXN_Y402

0.031

− 30.6

FGR_Y145

0.032

− 13.4

GSK3A_S282

0.036

− 2.2

RPS27_Y31

0.038

− 11.0

MAPRE2_Y167

0.040

− 5.3

MAPK1_Y187

0.041

− 5.6

MAPK1_T185

0.041

− 5.6

PAG1_Y317

0.042

− 5.3

PTPRK_Y871

0.042

− 5.3

PGAM1_Y92

0.042

− 3.6

CD84_Y165

0.044

− 5.4