Fig. 4
From: A pathway activity-based proteomic classifier stratifies prostate tumors into two subtypes
The validation of the proteomic pathways-based classifier in the TCGA dataset. A Heatmap showing the expression of 13 transcripts. The expression of transcript was normalized by Z-score across all PCa patients. B Unsupervised classification based on 13 transcripts enriched pathways at the transcriptomic level. C–D The t-SNE plots show the distribution of all tumor samples based on the ISUP standard and the pathway-based classifier utilizing the selected 13 transcripts, as depicted in Fig. 4A. E–F Overlay of proteomic-pathway-based subtypes with D’amico (E) and ISUP (F) classification standard for PCa. G–H Kaplan–Meier curves for the BCR-free (G) and metastasis-free (H) survival between the two subtypes