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Fig. 2 | Clinical Proteomics

Fig. 2

From: Frozen tissue coring and layered histological analysis improves cell type-specific proteogenomic characterization of pancreatic adenocarcinoma

Fig. 2

Coring enriched epithelial tissue but did not significantly differentiate tumor epithelial tissue from stromal tissue. A Principal component analysis for RNAseq data. All AT Epithelial samples had limited tissue availability and were not sequenced for RNA. B Principal component analysis for proteomics data. C Protein difference between tumor and AT in bulk tissue and epithelial-enriched cores. Some significantly enriched GO terms are highlighted. D Protein difference between tumor and AT in bulk tissue and stroma-enriched cores. E Difference in proteins between tumor epithelial-enriched cores and tumor stroma-enriched cores. F Percent increase of KRAS VAF from bulk tissue to epithelial-enriched cores and percent increase of KRAS VAF from stroma-enriched cores to epithelial-enriched cores

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Clinical Proteomics

ISSN: 1559-0275