Fig. 3

Tissue composition varies with core depth. A Percent neoplastic cells and desmoplastic stroma at the surface for each set of cores. B Average neoplastic cells percentage and desmoplastic stroma percent for each cored sample. Error bars are the standard deviation over at least three depths within the core. C (Top) OCT embedded PDAC frozen tissue cryosectioned at 5 µm and H&E stained with study pathologist selecting tumor rich (red, yellow) and stroma rich (blue) areas. (Bottom) Cryocores of selected regions 1.5 mm diameter with depths ranging from 4 to 7 mm placed en face in OCT