Fig. 2

Unsupervised hierarchical cluster analysis of differentially abundant proteins and transcripts. A 351 variably abundant proteins (MAD > 1) and B 464 variably abundant transcripts (MAD > 0.5) co-quantified in both the RNA-seq and mass spectrometry datasets. A Protein abundances are represented across 118 samples derived from n = 9 patients consisting of ET (n = 44 total; 4–5 levels/patient), ES (n = 29 total; 2–5 levels/patient), and BT (n = 45 total; 5 levels/patient). The color gradient inset below the heatmap depicts median tumor purity estimates per level, determined by manual pathology review for each of the BT collections