Fig. 7

Comparison of proteins altered between ET and ES in USC and stromal admixture scores with proteomic data generated from BT collections of USC tumors reported by Dou Y et al. 2020 [28]. A Proteins significantly co-altered (limma adj. p < 0.05) between ET and ES for n = 9 USC tumors (from Additional file 8: Tables S16 & S18; n = 455 proteins total) were correlated with global proteome data from bulk tissues collections for n = 9 USC tumors reported by Dou Y et al. Among 7908 total proteins quantified in all samples by Dou Y et al., 442 proteins were co-quantified in our cohort with tumor and stroma alterations. Correlation of the quantitative abundances for these 442 proteins were directly compared to metrics of tumor purity derived from analysis of methylation data (Purity_Cancer) as reported in Dou Y et al. B Stroma scores were calculated for global proteome data reported by Dou Y et al. using ProteoMixture [25] and directly compared to stroma purity metrics derived from methylation data (Purity_Stroma) reported by Dou Y et al.