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Fig. 2 | Clinical Proteomics

Fig. 2

From: Exploring the novel duo of Reticulocalbin, and Sideroflexin as future biomarker candidates for Exacerbated Chronic Obstructive Pulmonary Disease

Fig. 2

Differential expression of proteins in stable and excaerbated COPD with respect to healthy controls: (a) Venn diagram showing the unique and common differentially expressed proteins (DEPs) upregulated in stable and exacerbated COPD with respect to healthy controls. 40 DEPs were commonly up-regulated in stable and excaerbated variants with respect to HC, whereas 13 proteins in stable and 16 proteins in exacerbated COPD were uniquely up-regulated. (b) Venn diagram showing the unique and common differentially expressed proteins (DEPs) downregulated in stable and exacerbated COPD with respect to healthy controls. 8 DEPs were commonly downregulated in the COPD variants, whereas 7 proteins in stable and 1 protein in exacerbated COPD were uniquely down-regulated. (c) Volcano plot showing the DEPs obtained in stable and exacerbated COPD with respect to control. Upon filtering based on corrected p-value based on FDR, 68 DEPs in stable and 65 proteins in excaerbated COPD showed statistical significance and were taken for further analysis

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Clinical Proteomics

ISSN: 1559-0275