Table 2 A list of mass spectrometry-based glycoproteomic studies in urine since 2011
From: Recent progress in mass spectrometry-based urinary proteomics
Condition | Salient features | Technologies used | References |
|---|---|---|---|
Normal human urinary glycoproteomics | Glycoproteomic analysis of normal human urine in order to profile site-specific N- and O-glycosylation sites in the urine as well as urinary exosomes. Application of liquid handling system to enrich N-linked glycopeptides from urine was also demonstrated | LC–MS/MS CID-MS/MS LC–MS/MS along with Western blot | [54] [113] [109] [111] [114] [285] [286] [287] |
Cancer | Differential urinary glycoproteomic analysis to evaluate the alterations in different cancers (prostate cancer, papillary thyroid carcinoma, bladder cancer and hepatocellular carcinoma) at glycoprotein levels that could serve as biomarker or potential therapeutic targets | LC–MS/MS PRM-MS/MS | [288] [289] [290] [115] [61] [116] [117] |
Other diseases | Human urine glycoproteomic analysis in kidney-related diseases, diabetic nephropathy and Parkinson's disease | MALDI-TOF/TOF 2D-LC–MS/MS LC–MS/MS | [291] [292] [293] |