Table 3 Univariate analysis comparing OS and RFS in breast cancer
From: Proteomic analysis of breast cancer based on immune subtypes
Factors | OS | p | RFS | p |
|---|---|---|---|---|
Hazard Ratio (95% CI) | Hazard Ratio (95% CI) | |||
Age (≥ 50 vs. < 50) | 1.990 (0.495–7.999) | 0.332 | 1.475 (0.523–4.161) | 0.463 |
Intrinsic subtypes | ||||
HR + HER2- (ref.) | 1 | 1 | ||
HR + HER2 + | 3.572 (0.223–57.127) | 0.368 | 0.593 (0.071–4.942) | 0.629 |
HR− HER2 + | 0.000 | − | 0.542 (0.065–4.519) | 0.572 |
TNBC | 7.422 (0.911–60.480) | 0.061 | 1.712 (0.620–4.727) | 0.299 |
pCR vs. non-pCR | 0.026 (0.000–8.589) | 0.217 | 0.221 (0.050–0.964) | 0.045* |
RCB class | ||||
0 | 0.000 | − | 0.166 (0.030–0.909) | 0.038* |
I | 0.000 | − | 0.000 | − |
II | 1.009 (0.209–4.859) | 0.991 | 0.838 (0.270–2.604) | 0.760 |
III (ref.) | 1 | 1 | ||
Immune subtypes | ||||
Excluded/Desert (ref.) | 1 | 1 | ||
Inflamed | 1.716 (0.428–6.882) | 0.446 | 1.150 (0.437–3.027) | 0.777 |
TILs (≥ 10% vs. < 10%) | 1.872 (0.467–7.505) | 0.376 | 1.110 (0.437–2.819) | 0.826 |
TILs (%) | 1.019 (0.988–1.051) | 0.242 | 1.006 (0.978–1.034) | 0.690 |
Klintrup criteria (2,3 vs. 0,1) | 2.393 (0.496–11.543) | 0.277 | 1.175 (0.434–3.182) | 0.752 |
TLS score (2,3 vs. 0,1) | 3.360 (0.900–12.544) | 0.071 | 2.494 (0.920–6.761) | 0.073 |
Stroma (≥ 50% vs. < 50%) | 0.495 (0.133–1.845) | 0.295 | 0.742 (0.293–1.881) | 0.530 |