Fig. 3

Differentially expressed inflammatory proteins between healthy elderly individuals and elderly individuals with CMDs. (A) Volcano map of DEPs between healthy elderly individuals and elderly individuals with CMDs. (B) Heatmap shows the differentially expressed proteins (p < 0.05) in healthy elderly individuals and elderly individuals with CMDs. (C, D) The enrichment analysis results of GO and KEGG pathway analyses. An adjusted p-value < 0.05 was considered significant. (E) PPI network. Node size indicates the number of proteins that interact with it. Edge width indicates the strength of the interaction between the two proteins. (F) The node protein clusters with the highest score are constructed by the MCODE plug-in in Cytoscape. (G) The top 10 hub proteins were constructed by cytoHubba. The figure shows the top 10 hub genes constructed by the MCC method. (H) The common hub proteins calculated by seven algorithms of plug-in cytoHubba and their coexpressed genes were analyzed via GeneMANIA. (I) Box plot showing the relative expression of common hub proteins in DEPs between healthy elderly individuals and elderly individuals with CMDs