Fig. 4

Common DEPs between normal aging and CMDs. (A) PCA. The first two primary components (PC1 and PC2) are plotted. (B) Venn diagram shows an overlap of differentially expressed proteins between healthy young individuals vs. healthy elderly individuals and healthy elderly individuals vs. elderly individuals with cardio-metabolic disorder. (C) ROC curve analysis of overlapping proteins. (D) Correlation between differentially expressed proteins and clinical traits in cardio-metabolic disorder. Each cell contains a correlation coefficient. *p < 0.05, **p < 0.01, ***p < 0.001. (E) Box plot showing the relative expression of overlapping proteins