Table 2 Protein biomarkers and selected principal components with significant difference between three groups ( p <0.01)

SPMS vs. HC

Ratio⁽¹⁾

0.88

1.15

1.04

0.33

1.26

p⁽²⁾

0.7811

0.9358

0.9909

<0.0001

0.2423

0.9742

<0.0001

SPMS vs. NIND

Ratio⁽¹⁾

0.55

0.58

0.62

0.74

0.81

p⁽²⁾

0.0084

0.008

0.004

0.0502

0.1288

0.0093

0.1117

NIND vs. HC

Ratio

1.61

1.97

1.67

0.44

1.55

p⁽²⁾

0.1178

0.0136

0.0131

0.0004

0.0087

0.0529

0.0424

F-test (df=2)

p⁽³⁾

0.0078

0.0032

0.0019

<0.0001

0.0083

0.007

<0.0001