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Table 2 Highly expressed plasma membrane proteins in breast cancer cell lines

From: Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes

Overexpressed proteins identified
Gene MCF-7 SK-BR-3 DT22 DT28 MB-231 MCF-10A Protein
ERα-positive cells
 AGR2 135 0 0 0 0 0 Anterior gradient protein 2 homolog
 GCN1 107 37 81 52 32 7 eIF2-alpha kinase activator GCN1
HER2-positive cells
 ACLY 57 199 73 83 78 19 ATP-citrate synthase
 DHRS2 0 200 0 0 0 0 Dehydrogenase/reductase SDR family member 2
 SUSD2 8 412 0 0 0 4 Sushi domain-containing protein 2
TNBC
 EEF2 85 57 103 52 75 9 Elongation factor 2
 TNC 0 0 105 6 0 0 Tenascin
 PSMA5 25 11 51 219 33 6 Proteasome subunit alpha type-5
 BASP1 0 2 0 0 140 2 Brain acid soluble protein 1
 SLC1A5 18 10 34 14 115 6 Neutral amino acid transporter B(0)
 ECPAS 59 71 109 118 44 6 Proteasome adapter and scaffold protein ECM29
 TCP1 16 66 106 109 74 8 T-complex protein 1 subunit alpha
ERα-positive and HER2-positive cells
 FASN 107 393 46 21 60 30 Fatty acid synthase
ERα-positive and TNBC cells
 PA2G4 129 84 54 130 26 15 Proliferation-associated protein 2G4
HER2-positive and TNBC cells
 AHNAK 91 426 931 142 1219 103 Neuroblast differentiation-associated protein AHNAK
 TPP2 45 119 150 41 58 6 Tripeptidyl-peptidase 2
Multiple cell types
 EEF1A1 894 834 576 486 560 34 Elongation factor 1-alpha 1
 EEF1A2 739 525 157 87 154 11 Elongation factor 1-alpha 2
  1. The gene name, number of spectral counts identified in each cell line, and protein name are listed. SCs of more highly expressed proteins are bolditalic. MB-231 indicates MDA-MB-231 cells