Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes

Table 2 Highly expressed plasma membrane proteins in breast cancer cell lines

Overexpressed proteins identified
Gene	MCF-7	SK-BR-3	DT22	DT28	MB-231	MCF-10A	Protein
ERα-positive cells
AGR2	*135*	0	0	0	0	0	Anterior gradient protein 2 homolog
GCN1	*107*	37	81	52	32	7	eIF2-alpha kinase activator GCN1
HER2-positive cells
ACLY	57	*199*	73	83	78	19	ATP-citrate synthase
DHRS2	0	*200*	0	0	0	0	Dehydrogenase/reductase SDR family member 2
SUSD2	8	*412*	0	0	0	4	Sushi domain-containing protein 2
TNBC
EEF2	85	57	*103*	52	75	9	Elongation factor 2
TNC	0	0	*105*	6	0	0	Tenascin
PSMA5	25	11	51	*219*	33	6	Proteasome subunit alpha type-5
BASP1	0	2	0	0	*140*	2	Brain acid soluble protein 1
SLC1A5	18	10	34	14	*115*	6	Neutral amino acid transporter B(0)
ECPAS	59	71	*109*	*118*	44	6	Proteasome adapter and scaffold protein ECM29
TCP1	16	66	*106*	*109*	74	8	T-complex protein 1 subunit alpha
ERα-positive and HER2-positive cells
FASN	*107*	*393*	46	21	60	30	Fatty acid synthase
ERα-positive and TNBC cells
PA2G4	*129*	84	54	*130*	26	15	Proliferation-associated protein 2G4
HER2-positive and TNBC cells
AHNAK	91	*426*	*931*	142	*1219*	103	Neuroblast differentiation-associated protein AHNAK
TPP2	45	*119*	*150*	41	58	6	Tripeptidyl-peptidase 2
Multiple cell types
EEF1A1	*894*	*834*	*576*	*486*	*560*	34	Elongation factor 1-alpha 1
EEF1A2	*739*	*525*	*157*	87	*154*	11	Elongation factor 1-alpha 2

The gene name, number of spectral counts identified in each cell line, and protein name are listed. SCs of more highly expressed proteins are bolditalic. MB-231 indicates MDA-MB-231 cells

ISSN: 1559-0275