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  1. Content type: Research

    Toxoplasma encephalitis is caused by the opportunistic protozoan parasite Toxoplasma gondii. Primary infection with T. gondii in immunocompetent individuals remains largely asymptomatic. In contrast, in immunocom...

    Authors: Apeksha Sahu, Satwant Kumar, Sreelakshmi K Sreenivasamurthy, Lakshmi Dhevi N Selvan, Anil K Madugundu, Soujanya D Yelamanchi, Vinuth N Puttamallesh, Gourav Dey, Abhijith K Anil, Anand Srinivasan, Kanchan K Mukherjee, Harsha Gowda, Parthasarathy Satishchandra, Anita Mahadevan, Akhilesh Pandey, Thottethodi Subrahmanya Keshava Prasad…

    Citation: Clinical Proteomics 2014 11:39

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  2. Content type: Research

    The human epidermal growth factor receptor-2 (HER-2) expression level is a critical element for determining the prognosis and management of breast cancer. HER-2 targeted therapy in breast cancer depends on the...

    Authors: Candice Perry, Catherine M Conway, Jeong Won Ha, Till Braunschweig, Jennifer Morris, Kris Ylaya, Hanbyoul Cho, Joon-Yong Chung and Stephen M Hewitt

    Citation: Clinical Proteomics 2014 11:36

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  3. Content type: Research

    Rheumatic fever in childhood is the most common cause of Mitral Stenosis in developing countries. The disease is characterized by damaged and deformed mitral valves predisposing them to scarring and narrowing ...

    Authors: Somaditya Mukherjee, Mashanipalya G Jagadeeshaprasad, Tanima Banerjee, Sudip K Ghosh, Monodeep Biswas, Santanu Dutta, Mahesh J Kulkarni, Sanjib Pattari and Arun Bandyopadhyay

    Citation: Clinical Proteomics 2014 11:35

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  4. Content type: Research

    Cardiac diseases (e.g. coronary and valve) are associated with ventricular cellular remodeling. However, ventricular biopsies from left and right ventricles from patients with different pathologies are rare an...

    Authors: Ben Littlejohns, Kate Heesom, Gianni D Angelini and M-Saadeh Suleiman

    Citation: Clinical Proteomics 2014 11:34

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  5. Content type: Letter to the editor

    Osteoarthritis (OA) is considered the most prevalent form of arthritis. The aim of this study was to verify potential protein OA biomarkers by applying Selected Reaction Monitoring (SRM) assays to protein extr...

    Authors: Emilio Camafeita, José-Ramón Lamas, Enrique Calvo, Pilar Tornero-Esteban, Juan-Antonio López and Benjamín Fernández-Gutiérrez

    Citation: Clinical Proteomics 2014 11:33

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  6. Content type: Research

    CT screening for lung cancer is effective in reducing mortality, but there are areas of concern, including a positive predictive value of 4% and development of interval cancers. A blood test that could manage ...

    Authors: Michael R Mehan, Stephen A Williams, Jill M Siegfried, William L Bigbee, Joel L Weissfeld, David O Wilson, Harvey I Pass, William N Rom, Thomas Muley, Michael Meister, Wilbur Franklin, York E Miller, Edward N Brody and Rachel M Ostroff

    Citation: Clinical Proteomics 2014 11:32

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  7. Content type: Research

    Until now, the major prognostic factors for pediatric acute lymphoblastic leukemia (ALL), age, white blood cell count and chromosomal alterations are initially taken into account for the risk stratification of...

    Authors: Odile Costa, Pascale Schneider, Laurent Coquet, Philippe Chan, Dominique Penther, Elisabeth Legrand, Thierry Jouenne, Marc Vasse and Jean-Pierre Vannier

    Citation: Clinical Proteomics 2014 11:31

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  8. Content type: Research

    The proteomic analysis of body fluids is a growing technology for the identification of protein biomarkers of disease. Given that Papanicolaou tests (Pap tests) are routinely performed on over 30 million women...

    Authors: Kristin LM Boylan, Somaieh Afiuni-Zadeh, Melissa A Geller, Kayla Hickey, Timothy J Griffin, Stefan E Pambuccian and Amy PN Skubitz

    Citation: Clinical Proteomics 2014 11:30

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  9. Content type: Research

    The vitreous humor is a transparent, gelatinous mass whose main constituent is water. It plays an important role in providing metabolic nutrient requirements of the lens, coordinating eye growth and providing ...

    Authors: Krishna R Murthy, Renu Goel, Yashwanth Subbannayya, Harrys KC Jacob, Praveen R Murthy, Srikanth Srinivas Manda, Arun H Patil, Rakesh Sharma, Nandini A Sahasrabuddhe, Arun Parashar, Bipin G Nair, Venkatarangaiah Krishna, TS Keshava Prasad, Harsha Gowda and Akhilesh Pandey

    Citation: Clinical Proteomics 2014 11:29

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  10. Content type: Research

    The growing field of formalin-fixed paraffin-embedded (FFPE) tissue proteomics holds promise for improving translational research. Direct tissue trypsinization (DT) and protein extraction followed by in soluti...

    Authors: Alessandro Tanca, Marcello Abbondio, Salvatore Pisanu, Daniela Pagnozzi, Sergio Uzzau and Maria Filippa Addis

    Citation: Clinical Proteomics 2014 11:28

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  11. Content type: Research

    Dysregulation of glycoproteins is closely related with many diseases. Quantitative proteomics methods are powerful tools for the detection of glycoprotein alterations. However, in almost all quantitative glyco...

    Authors: Zhen Sun, Deguang Sun, Fangjun Wang, Kai Cheng, Zhang Zhang, Bo Xu, Mingliang Ye, Liming Wang and Hanfa Zou

    Citation: Clinical Proteomics 2014 11:26

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  12. Content type: Research

    Synovial fluid (SF) is a dynamic reservoir for proteins originating from the synovial membrane, cartilage, and plasma, and may therefore reflect the pathophysiological conditions that give rise to arthritis. O...

    Authors: Daniela Cretu, Ioannis Prassas, Punit Saraon, Ihor Batruch, Rajiv Gandhi, Eleftherios P Diamandis and Vinod Chandran

    Citation: Clinical Proteomics 2014 11:27

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  13. Content type: Research

    Glycoproteins comprise a large portion of the salivary proteome and have great potential for biomarker discovery and disease diagnosis. However, the rate of production and the concentration of whole saliva cha...

    Authors: Shisheng Sun, Fei Zhao, Qinzhe Wang, Yaogang Zhong, Tanxi Cai, Peng Wu, Fuquan Yang and Zheng Li

    Citation: Clinical Proteomics 2014 11:25

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  14. Content type: Research

    Histone post-translational modifications (PTMs) play an important role in the regulation of the expression of genes, including those involved in cancer development and progression. However, our knowledge of PT...

    Authors: Jakub Karczmarski, Tymon Rubel, Agnieszka Paziewska, Michal Mikula, Mateusz Bujko, Paulina Kober, Michal Dadlez and Jerzy Ostrowski

    Citation: Clinical Proteomics 2014 11:24

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  15. Content type: Research

    Ovarian cancer (OvCa) is the most lethal gynecological malignancy. The emergence of high-throughput technologies, such as mass spectrometry, has allowed for a paradigm shift in the way we search for novel biom...

    Authors: Christopher R Smith, Ihor Batruch, Josep Miquel Bauça, Hari Kosanam, Julia Ridley, Marcus Q Bernardini, Felix Leung, Eleftherios P Diamandis and Vathany Kulasingam

    Citation: Clinical Proteomics 2014 11:23

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  16. Content type: Review

    Protein glycosylation, as an important post-translational modification, is implicated in a number of ailments. Applying proteomic approaches, including mass spectrometry (MS) analyses that have played a signif...

    Authors: Hu Zhao, Yaojun Li and Ye Hu

    Citation: Clinical Proteomics 2014 11:21

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  17. Content type: Research

    Adipose tissue is both an energy storage depot and an endocrine organ. The impaired regulation of the secreted proteins of adipose tissue, known as adipocytokines, observed during obesity contributes to the on...

    Authors: Jae-Min Lim, Edith E Wollaston-Hayden, Chin Fen Teo, Dorothy Hausman and Lance Wells

    Citation: Clinical Proteomics 2014 11:20

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  18. Content type: Research

    Estrogen has been shown to mediate protection in female hearts against ischemia-reperfusion (I-R) stress. Composed by a Kir6.2 pore and an SUR2 regulatory subunit, cardiac ATP-sensitive potassium channels (KAT...

    Authors: Jianjiong Gao, Dong Xu, Grzegorz Sabat, Hector Valdivia, Wei Xu and Nian-Qing Shi

    Citation: Clinical Proteomics 2014 11:19

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  19. Content type: Research

    Peritoneal dialysis (PD) is a form of renal replacement used for advanced chronic kidney disease. PD effluent holds a great potential for biomarker discovery for diagnosis and prognosis. In this study a novel ...

    Authors: Elisabete Oliveira, José E Araújo, Silvana Gómez-Meire, Carlos Lodeiro, Cristina Perez-Melon, Elena Iglesias-Lamas, Alfonso Otero-Glez, José L Capelo and Hugo M Santos

    Citation: Clinical Proteomics 2014 11:17

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  20. Content type: Review

    Gel- based proteomics is one of the most versatile methods for fractionating protein complexes. Among these methods, two dimensional- polyacrylamide gel electrophoresis (2-DE) represents a mainstay orthogonal ...

    Authors: Sameh Magdeldin, Shymaa Enany, Yutaka Yoshida, Bo Xu, Ying Zhang, Zam Zureena, Ilambarthi Lokamani, Eishin Yaoita and Tadashi Yamamoto

    Citation: Clinical Proteomics 2014 11:16

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  21. Content type: Review

    Protein glycosylation serves critical roles in the cellular and biological processes of many organisms. Aberrant glycosylation has been associated with many illnesses such as hereditary and chronic diseases li...

    Authors: Deniz Baycin Hizal, Daniel Wolozny, Joseph Colao, Elena Jacobson, Yuan Tian, Sharon S Krag, Michael J Betenbaugh and Hui Zhang

    Citation: Clinical Proteomics 2014 11:15

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  22. Content type: Review

    Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associate...

    Authors: Huan Liu, Ningbo Zhang, Debin Wan, Meng Cui, Zhiqiang Liu and Shuying Liu

    Citation: Clinical Proteomics 2014 11:14

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  23. Content type: Research

    Conventional proteomic approaches have thus far been unable to identify novel serum biomarkers for ovarian cancer that are more sensitive and specific than the current clinically used marker, CA-125. Because e...

    Authors: Anand Bery, Felix Leung, Christopher R Smith, Eleftherios P Diamandis and Vathany Kulasingam

    Citation: Clinical Proteomics 2014 11:13

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  24. Content type: Research

    Transthyretin (TTR), an abundant protein in cerebrospinal fluid (CSF), contains a free, oxidation-prone cysteine residue that gives rise to TTR isoforms. These isoforms may reflect conditions in vivo. Since incre...

    Authors: Keld Poulsen, Justyna MC Bahl, Anja H Simonsen, Steen G Hasselbalch and Niels HH Heegaard

    Citation: Clinical Proteomics 2014 11:12

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  25. Content type: Research

    It is well known that cell surface glycans or glycocalyx play important roles in sperm motility, maturation and fertilization. A comprehensive profile of the sperm surface glycans will greatly facilitate both ...

    Authors: Ai-Jie Xin, Li Cheng, Hua Diao, Peng Wang, Yi-Hua Gu, Bin Wu, Yan-Cheng Wu, Guo-Wu Chen, Shu-Min Zhou, Shu-Juan Guo, Hui-Juan Shi and Sheng-Ce Tao

    Citation: Clinical Proteomics 2014 11:10

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  26. Content type: Research

    Glycoproteins secreted into plasma from T cells infected with human immunodeficiency virus (HIV) latent infection may provide insight into understanding the host response to HIV infection in vivo. Glycoproteomics...

    Authors: Weiming Yang, Jian-Ying Zhou, Li Chen, Minghui Ao, Shisheng Sun, Paul Aiyetan, Antoine Simmons, Hui Zhang and Jay Brooks Jackson

    Citation: Clinical Proteomics 2014 11:9

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  27. Content type: Review

    O-linked β-D-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) onto serine and threonine residues of proteins is an important post-translational modification (PTM), which is involved in many crucial b...

    Authors: Junfeng Ma and Gerald W Hart

    Citation: Clinical Proteomics 2014 11:8

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  28. Content type: Research

    Analysis of native or endogenous peptides in biofluids can provide valuable insights into disease mechanisms. Furthermore, the detected peptides may also have utility as potential biomarkers for non-invasive m...

    Authors: Tara K Sigdel, Carrie D Nicora, Szu-Chuan Hsieh, Hong Dai, Wei-Jun Qian, David G Camp II and Minnie M Sarwal

    Citation: Clinical Proteomics 2014 11:7

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  29. Content type: Research

    Osteoarthritis is a chronic musculoskeletal disorder characterized mainly by progressive degradation of the hyaline cartilage. Patients with osteoarthritis often postpone seeking medical help, which results in...

    Authors: Lavanya Balakrishnan, Raja Sekhar Nirujogi, Sartaj Ahmad, Mitali Bhattacharjee, Srikanth S Manda, Santosh Renuse, Dhanashree S Kelkar, Yashwanth Subbannayya, Rajesh Raju, Renu Goel, Joji Kurian Thomas, Navjyot Kaur, Mukesh Dhillon, Shantal Gupta Tankala, Ramesh Jois, Vivek Vasdev…

    Citation: Clinical Proteomics 2014 11:6

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  30. Content type: Research

    Cryptococcus neoformans, a basidiomycetous fungus of universal occurrence, is a significant opportunistic human pathogen causing meningitis. Owing to an increase in the number of immunosuppressed individuals alon...

    Authors: Lakshmi Dhevi Nagarajha Selvan, Jyothi Embekkat Kaviyil, Raja Sekhar Nirujogi, Babylakshmi Muthusamy, Vinuth N Puttamallesh, Tejaswini Subbannayya, Nazia Syed, Aneesha Radhakrishnan, Dhanashree S Kelkar, Sartaj Ahmad, Sneha M Pinto, Praveen Kumar, Anil K Madugundu, Bipin Nair, Aditi Chatterjee, Akhilesh Pandey…

    Citation: Clinical Proteomics 2014 11:5

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  31. Content type: Research

    Numerous formaldehyde-fixed and paraffin-embedded clinical tissues have been created in the past decades and stored in pathological depositories at hospitals as well as in clinical laboratories worldwide. In a...

    Authors: Yusuke Kawashima, Yoshio Kodera, Anil Singh, Masaomi Matsumoto and Hiroyuki Matsumoto

    Citation: Clinical Proteomics 2014 11:4

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  32. Content type: Research

    Protein biomarkers offer major benefits for diagnosis and monitoring of disease processes. Recent advances in protein mass spectrometry make it feasible to use this very sensitive technology to detect and quan...

    Authors: John Marshall, Peter Bowden, Jean Claude Schmit and Fay Betsou

    Citation: Clinical Proteomics 2014 11:3

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  33. Content type: Research

    Experts agree that one of the more promising strategies in cancer management is early detection coupled with early intervention. In this study, we evaluated an early cancer detection strategy of cancer presenc...

    Authors: Claudia Hanau, D James Morré and Dorothy M Morré

    Citation: Clinical Proteomics 2014 11:2

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  34. Content type: Research

    Rheumatoid arthritis and osteoarthritis are two common musculoskeletal disorders that affect the joints. Despite high prevalence rates, etiological factors involved in these disorders remain largely unknown. D...

    Authors: Lavanya Balakrishnan, Mitali Bhattacharjee, Sartaj Ahmad, Raja Sekhar Nirujogi, Santosh Renuse, Yashwanth Subbannayya, Arivusudar Marimuthu, Srinivas M Srikanth, Rajesh Raju, Mukesh Dhillon, Navjyot Kaur, Ramesh Jois, Vivek Vasudev, YL Ramachandra, Nandini A Sahasrabuddhe, TS Keshava Prasad…

    Citation: Clinical Proteomics 2014 11:1

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  35. Content type: Research

    Plasma renin activity (PRA) is an essential analytical tool for screening and diagnosis of secondary forms of hypertension. Typically, PRA is measured by competitive radioimmunoassay, but there are significant...

    Authors: Alexander G Camenzind, Jessica Grace van der Gugten, Robert Popp, Daniel T Holmes and Christoph H Borchers

    Citation: Clinical Proteomics 2013 10:20

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  36. Content type: Research

    Potential biomarkers to aid diagnosis and therapy need to be identified for Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The present study was designed to identify the fac...

    Authors: Anu Mary Varghese, Aparna Sharma, Poojashree Mishra, Kalyan Vijayalakshmi, Hindalahalli Chandregowda Harsha, Talakad N Sathyaprabha, Srinivas MM Bharath, Atchayaram Nalini, Phalguni Anand Alladi and Trichur R Raju

    Citation: Clinical Proteomics 2013 10:19

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  37. Content type: Research

    The rapid advancement of high-throughput tools for quantitative measurement of proteins has demonstrated the potential for the identification of proteins associated with cancer. However, the quantitative resul...

    Authors: Jing Chen, Shadi Toghi Eshghi, George Steven Bova, Qing Kay Li, Xingde Li and Hui Zhang

    Citation: Clinical Proteomics 2013 10:18

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  38. Content type: Research

    Serine hydrolases constitute a large enzyme family involved in a diversity of proteolytic and metabolic processes which are essential for many aspects of normal physiology. The roles of serine hydrolases in re...

    Authors: Mario Navarrete, Julie Ho, Oleg Krokhin, Peyman Ezzati, Claudio Rigatto, Martina Reslerova, David N Rush, Peter Nickerson and John A Wilkins

    Citation: Clinical Proteomics 2013 10:17

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  39. Content type: Research

    Serum biomarkers can improve diagnosis and treatment of malignant pleural mesothelioma (MPM). However, the evaluation of potential new serum biomarker candidates is hampered by a lack of assay technologies for...

    Authors: Ferdinando Cerciello, Meena Choi, Annalisa Nicastri, Damaris Bausch-Fluck, Annemarie Ziegler, Olga Vitek, Emanuela Felley-Bosco, Rolf Stahel, Ruedi Aebersold and Bernd Wollscheid

    Citation: Clinical Proteomics 2013 10:16

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  40. Content type: Research

    Lung cancer is the number one cause of cancer-related deaths in the United States and worldwide. The complex protein changes and/or signature of protein expression in lung cancer, particularly in non-small cel...

    Authors: Yan Li, Xiangchun Wang, MingHui Ao, Edward Gabrielson, Frederic Askin, Hui Zhang and Qing Kay Li

    Citation: Clinical Proteomics 2013 10:15

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  41. Content type: Research

    Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-stranded RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis and host...

    Authors: Vinuth N Puttamallesh, Sreelakshmi K Sreenivasamurthy, Pradeep Kumar Singh, H C Harsha, Anjali Ganjiwale, Shobha Broor, Akhilesh Pandey, Jayasuryan Narayana and T S Keshava Prasad

    Citation: Clinical Proteomics 2013 10:14

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  42. Content type: Research

    Arthritis refers to inflammation of joints and includes common disorders such as rheumatoid arthritis (RA) and spondyloarthropathies (SpAs). These diseases differ mainly in terms of their clinical manifestatio...

    Authors: Mitali Bhattacharjee, Rakesh Sharma, Renu Goel, Lavanya Balakrishnan, Santosh Renuse, Jayshree Advani, Shantal Tankala Gupta, Renu Verma, Sneha M Pinto, Nirujogi Raja Sekhar, Bipin Nair, T S Keshava Prasad, H C Harsha, Ramesh Jois, Subramanian Shankar and Akhilesh Pandey

    Citation: Clinical Proteomics 2013 10:11

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  43. Content type: Research

    To characterize changes in global protein expression in kidneys of transgenic rats overexpressing human selenoprotein M (SelM) in response to increased bioabivility of selenium (Sel), total proteins extracted ...

    Authors: Jun Seo Goo, Yo Na Kim, Kyung Mi Choi, In Sik Hwang, Ji Eun Kim, Young Ju Lee, Moon Hwa Kwak, Sun Bo Shim, Seung Wan Jee, Chul Joo Lim, Je Kyung Seong and Dae Youn Hwang

    Citation: Clinical Proteomics 2013 10:10

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  44. Content type: Research

    The ciliary body is the circumferential muscular tissue located just behind the iris in the anterior chamber of the eye. It plays a pivotal role in the production of aqueous humor, maintenance of the lens zonu...

    Authors: Renu Goel, Krishna R Murthy, Srinivas M Srikanth, Sneha M Pinto, Mitali Bhattacharjee, Dhanashree S Kelkar, Anil K Madugundu, Gourav Dey, Sujatha S Mohan, Venkatarangaiah Krishna, TS Keshava Prasad, Shukti Chakravarti, HC Harsha and Akhilesh Pandey

    Citation: Clinical Proteomics 2013 10:9

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