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  1. Content type: Research

    Post-translational modification by ubiquitin is a fundamental regulatory mechanism that is implicated in many cellular processes including the cell cycle, apoptosis, cell adhesion, angiogenesis, and tumor grow...

    Authors: Stefani N Thomas, Hui Zhang and Robert J Cotter

    Citation: Clinical Proteomics 2015 12:14

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  2. Content type: Research

    Breast cancer is a very heterogeneous disease and some patients are cured by the surgical removal of the primary tumour whilst other patients suffer from metastasis and spreading of the disease, despite adjuva...

    Authors: Emila Kurbasic, Martin Sjöström, Morten Krogh, Elin Folkesson, Dorthe Grabau, Karin Hansson, Lisa Rydén, Sofia Waldemarson, Peter James and Emma Niméus

    Citation: Clinical Proteomics 2015 12:13

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  3. Content type: Research

    Osteoarthritis (OA) is a multi-factorial disease leading progressively to loss of articular cartilage and subsequently to loss of joint function. While hypertrophy of chondrocytes is a physiological process im...

    Authors: Konstantinos C Tsolis, Ekaterini S Bei, Ioanna Papathanasiou, Fotini Kostopoulou, Vassiliki Gkretsi, Kalliopi Kalantzaki, Konstantinos Malizos, Michalis Zervakis, Aspasia Tsezou and Anastassios Economou

    Citation: Clinical Proteomics 2015 12:12

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  4. Content type: Research

    In this study, we investigated the use of metabolic oligosaccharide engineering and bio-orthogonal ligation reactions combined with lectin microarray and mass spectrometry to analyze sialoglycoproteins in the ...

    Authors: Yuan Tian, Ruben T Almaraz, Caitlin H Choi, Qing Kay Li, Christopher Saeui, Danni Li, Punit Shah, Rahul Bhattacharya, Kevin J Yarema and Hui Zhang

    Citation: Clinical Proteomics 2015 12:11

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  5. Content type: Research

    Current methods widely deployed for colorectal cancers (CRC) screening lack the necessary sensitivity and specificity required for population-based early disease detection. Cancer-specific protein biomarkers a...

    Authors: Sadia Mahboob, Seong Beom Ahn, Harish R Cheruku, David Cantor, Emma Rennel, Simon Fredriksson, Gabriella Edfeldt, Edmond J Breen, Alamgir Khan, Abidali Mohamedali, Md Golam Muktadir, Shoba Ranganathan, Sock-Hwee Tan, Edouard Nice and Mark S Baker

    Citation: Clinical Proteomics 2015 12:10

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  6. Content type: Research

    The established methods of antenatal screening for Down syndrome are based on immunoassay for a panel of maternal serum biomarkers together with ultrasound measures. Recently, genetic analysis of maternal plas...

    Authors: Ray K Iles, Maryam E Shahpari, Howard Cuckle and Stephen A Butler

    Citation: Clinical Proteomics 2015 12:9

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  7. Content type: Research

    Despite the success of tamoxifen since its introduction, about one-third of patients with estrogen (ER) and/or progesterone receptor (PgR) - positive breast cancer (BC) do not benefit from therapy. Here, we ai...

    Authors: Henrik J Johansson, Betzabe C Sanchez, Jenny Forshed, Olle Stål, Helena Fohlin, Rolf Lewensohn, Per Hall, Jonas Bergh, Janne Lehtiö and Barbro K Linderholm

    Citation: Clinical Proteomics 2015 12:8

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  8. Content type: Research

    The bacterium Burkholderia mallei is the etiological agent of glanders, a highly contagious, often fatal zoonotic infectious disease that is also a biodefense concern. Clinical laboratory assays that analyze bloo...

    Authors: Trevor G Glaros, Candace D Blancett, Todd M Bell, Mohan Natesan and Robert G Ulrich

    Citation: Clinical Proteomics 2015 12:7

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  9. Content type: Research

    The MALDI (matrix-assisted laser desorption/ionization) Biotyper system for bacterial identification has already been utilized in clinical microbiology laboratories as a successful clinical application of prot...

    Authors: Shunsuke Segawa, Motoi Nishimura, Kazuyuki Sogawa, Sachio Tsuchida, Shota Murata, Masaharu Watanabe, Kazuyuki Matsushita, Katsuhiko Kamei and Fumio Nomura

    Citation: Clinical Proteomics 2015 12:6

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  10. Content type: Research

    Follicular fluid is a unique biological fluid in which the critical events of oocyte and follicular maturation and somatic cell-germ cell communication occur. Because of the intimate proximity of follicular fl...

    Authors: Alberuni M Zamah, Maria E Hassis, Matthew E Albertolle and Katherine E Williams

    Citation: Clinical Proteomics 2015 12:5

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  11. Content type: Research

    Elevated levels of reactive oxygen species (ROS) are detected in 25% to 80% of infertile men. They are involved in the pathology of male infertility. Understanding the effect of increasing levels of ROS on the...

    Authors: Ahmet Ayaz, Ashok Agarwal, Rakesh Sharma, Mohamed Arafa, Haitham Elbardisi and Zhihong Cui

    Citation: Clinical Proteomics 2015 12:4

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  12. Content type: Research

    Current quantification methods for mass spectrometry (MS)-based proteomics either do not provide sufficient control of variability or are difficult to implement for routine clinical testing.

    Authors: Xiao-jun Li, Lik Wee Lee, Clive Hayward, Mi-Youn Brusniak, Pui-Yee Fong, Matthew McLean, JoAnne Mulligan, Douglas Spicer, Kenneth C Fang, Stephen W Hunsucker and Paul Kearney

    Citation: Clinical Proteomics 2015 12:3

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  13. Content type: Research

    The anatomy of PFO suggests that it can allow thrombi and potentially harmful circulatory factors to travel directly from the venous to the arterial circulation – altering circulatory phenotype. Our previous p...

    Authors: Mary F Lopez, Bryan Krastins, David A Sarracino, Gregory Byram, Maryann S Vogelsang, Amol Prakash, Scott Peterman, Shadab Ahmad, Gouri Vadali, Wenjun Deng, Ignacio Inglessis, Tom Wickham, Kathleen Feeney, G William Dec, Igor Palacios, Ferdinando S Buonanno…

    Citation: Clinical Proteomics 2015 12:2

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  14. Content type: Research

    Psoriatic arthritis (PsA) is a distinct inflammatory arthritis occurring in 30% of psoriasis patients. There is a high prevalence of undiagnosed PsA in psoriasis patients; therefore, identifying soluble biomar...

    Authors: Daniela Cretu, Kun Liang, Punit Saraon, Ihor Batruch, Eleftherios P Diamandis and Vinod Chandran

    Citation: Clinical Proteomics 2015 12:1

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  15. Content type: Meeting report

    In the past two decades, our ability to study cellular and molecular systems has been transformed through the development of omics sciences. While unlimited potential lies within massive omics datasets, the su...

    Authors: Emily S Boja, Christopher R Kinsinger, Henry Rodriguez and Pothur Srinivas

    Citation: Clinical Proteomics 2014 11:45

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  16. Content type: Research

    A combination treatment of interferon and ribavirin is the standard and the commonly used treatment for chronic hepatitis C (CHC). Developing noninvasive tests like serum indicators that can predict treatment ...

    Authors: Xia Zou, Xiumei Chi, Yu Pan, Dongning Du, Haibo Sun, Atsushi Matsuda, Wei Li, Atsushi Kuno, Xinxin Zhang, Hisashi Narimatsu, Junqi Niu and Yan Zhang

    Citation: Clinical Proteomics 2014 11:44

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  17. Content type: Research

    In our previous study that characterized different human CD4+ lymphocyte preparations, it was found that both commercially available cryopreserved peripheral blood mononuclear cells (PBMC) and a commercially a...

    Authors: Meiyao Wang, Martin Misakian, Hua-Jun He, Peter Bajcsy, Fatima Abbasi, Jeffrey M Davis, Kenneth D Cole, Illarion V Turko and Lili Wang

    Citation: Clinical Proteomics 2014 11:43

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  18. Content type: Research

    Pancreatic cysts are being increasingly identified in patients. Mucinous cysts have malignant potential whereas non-mucinous cysts do not. Distinguishing potentially malignant cysts from harmless ones by the c...

    Authors: John M Streitz, Michael T Madden, Wilmar Salo, Kirk P Bernadino, Joseph L Deutsch and John C Deutsch

    Citation: Clinical Proteomics 2014 11:42

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  19. Content type: Research

    Fibroblasts are mesenchymal stromal cells which occur in all tissue types. While their main function is related to ECM production and physical support, they are also important players in wound healing, and hav...

    Authors: Astrid Slany, Anastasia Meshcheryakova, Agnes Beer, Hendrik Jan Ankersmit, Verena Paulitschke and Christopher Gerner

    Citation: Clinical Proteomics 2014 11:41

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  20. Content type: Research

    Placental syncytiotrophoblast microvesicles (STBM) are shed into the maternal circulation during normal pregnancy. STBM circulate in significantly increased amounts in preeclampsia (PE) and are considered to b...

    Authors: Sonia Baig, Narasimhan Kothandaraman, Jayapal Manikandan, Li Rong, Kim Huey EE, Jeffrey Hill, Chin Wee Lai, Wan Yu Tan, Felicia Yeoh, Anita Kale, Lin Lin Su, Arijit Biswas, Sheila Vasoo and Mahesh Choolani

    Citation: Clinical Proteomics 2014 11:40

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  21. Content type: Research

    Toxoplasma encephalitis is caused by the opportunistic protozoan parasite Toxoplasma gondii. Primary infection with T. gondii in immunocompetent individuals remains largely asymptomatic. In contrast, in immunocom...

    Authors: Apeksha Sahu, Satwant Kumar, Sreelakshmi K Sreenivasamurthy, Lakshmi Dhevi N Selvan, Anil K Madugundu, Soujanya D Yelamanchi, Vinuth N Puttamallesh, Gourav Dey, Abhijith K Anil, Anand Srinivasan, Kanchan K Mukherjee, Harsha Gowda, Parthasarathy Satishchandra, Anita Mahadevan, Akhilesh Pandey, Thottethodi Subrahmanya Keshava Prasad…

    Citation: Clinical Proteomics 2014 11:39

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  22. Content type: Research

    The use of targeted LC-MS/MS methods for protein quantitation in clinical laboratories implies a careful evaluation of potential sources of analytical interference. In this study, we investigated whether infla...

    Authors: Olivier Lassout, Denis Hochstrasser and Pierre Lescuyer

    Citation: Clinical Proteomics 2014 11:38

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  23. Content type: Research

    The human epidermal growth factor receptor-2 (HER-2) expression level is a critical element for determining the prognosis and management of breast cancer. HER-2 targeted therapy in breast cancer depends on the...

    Authors: Candice Perry, Catherine M Conway, Jeong Won Ha, Till Braunschweig, Jennifer Morris, Kris Ylaya, Hanbyoul Cho, Joon-Yong Chung and Stephen M Hewitt

    Citation: Clinical Proteomics 2014 11:36

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  24. Content type: Research

    Rheumatic fever in childhood is the most common cause of Mitral Stenosis in developing countries. The disease is characterized by damaged and deformed mitral valves predisposing them to scarring and narrowing ...

    Authors: Somaditya Mukherjee, Mashanipalya G Jagadeeshaprasad, Tanima Banerjee, Sudip K Ghosh, Monodeep Biswas, Santanu Dutta, Mahesh J Kulkarni, Sanjib Pattari and Arun Bandyopadhyay

    Citation: Clinical Proteomics 2014 11:35

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  25. Content type: Research

    Cardiac diseases (e.g. coronary and valve) are associated with ventricular cellular remodeling. However, ventricular biopsies from left and right ventricles from patients with different pathologies are rare an...

    Authors: Ben Littlejohns, Kate Heesom, Gianni D Angelini and M-Saadeh Suleiman

    Citation: Clinical Proteomics 2014 11:34

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  26. Content type: Letter to the editor

    Osteoarthritis (OA) is considered the most prevalent form of arthritis. The aim of this study was to verify potential protein OA biomarkers by applying Selected Reaction Monitoring (SRM) assays to protein extr...

    Authors: Emilio Camafeita, José-Ramón Lamas, Enrique Calvo, Pilar Tornero-Esteban, Juan-Antonio López and Benjamín Fernández-Gutiérrez

    Citation: Clinical Proteomics 2014 11:33

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  27. Content type: Research

    CT screening for lung cancer is effective in reducing mortality, but there are areas of concern, including a positive predictive value of 4% and development of interval cancers. A blood test that could manage ...

    Authors: Michael R Mehan, Stephen A Williams, Jill M Siegfried, William L Bigbee, Joel L Weissfeld, David O Wilson, Harvey I Pass, William N Rom, Thomas Muley, Michael Meister, Wilbur Franklin, York E Miller, Edward N Brody and Rachel M Ostroff

    Citation: Clinical Proteomics 2014 11:32

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  28. Content type: Research

    Until now, the major prognostic factors for pediatric acute lymphoblastic leukemia (ALL), age, white blood cell count and chromosomal alterations are initially taken into account for the risk stratification of...

    Authors: Odile Costa, Pascale Schneider, Laurent Coquet, Philippe Chan, Dominique Penther, Elisabeth Legrand, Thierry Jouenne, Marc Vasse and Jean-Pierre Vannier

    Citation: Clinical Proteomics 2014 11:31

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  29. Content type: Research

    The proteomic analysis of body fluids is a growing technology for the identification of protein biomarkers of disease. Given that Papanicolaou tests (Pap tests) are routinely performed on over 30 million women...

    Authors: Kristin LM Boylan, Somaieh Afiuni-Zadeh, Melissa A Geller, Kayla Hickey, Timothy J Griffin, Stefan E Pambuccian and Amy PN Skubitz

    Citation: Clinical Proteomics 2014 11:30

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  30. Content type: Research

    The vitreous humor is a transparent, gelatinous mass whose main constituent is water. It plays an important role in providing metabolic nutrient requirements of the lens, coordinating eye growth and providing ...

    Authors: Krishna R Murthy, Renu Goel, Yashwanth Subbannayya, Harrys KC Jacob, Praveen R Murthy, Srikanth Srinivas Manda, Arun H Patil, Rakesh Sharma, Nandini A Sahasrabuddhe, Arun Parashar, Bipin G Nair, Venkatarangaiah Krishna, TS Keshava Prasad, Harsha Gowda and Akhilesh Pandey

    Citation: Clinical Proteomics 2014 11:29

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  31. Content type: Research

    The growing field of formalin-fixed paraffin-embedded (FFPE) tissue proteomics holds promise for improving translational research. Direct tissue trypsinization (DT) and protein extraction followed by in soluti...

    Authors: Alessandro Tanca, Marcello Abbondio, Salvatore Pisanu, Daniela Pagnozzi, Sergio Uzzau and Maria Filippa Addis

    Citation: Clinical Proteomics 2014 11:28

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  32. Content type: Research

    Synovial fluid (SF) is a dynamic reservoir for proteins originating from the synovial membrane, cartilage, and plasma, and may therefore reflect the pathophysiological conditions that give rise to arthritis. O...

    Authors: Daniela Cretu, Ioannis Prassas, Punit Saraon, Ihor Batruch, Rajiv Gandhi, Eleftherios P Diamandis and Vinod Chandran

    Citation: Clinical Proteomics 2014 11:27

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  33. Content type: Research

    Dysregulation of glycoproteins is closely related with many diseases. Quantitative proteomics methods are powerful tools for the detection of glycoprotein alterations. However, in almost all quantitative glyco...

    Authors: Zhen Sun, Deguang Sun, Fangjun Wang, Kai Cheng, Zhang Zhang, Bo Xu, Mingliang Ye, Liming Wang and Hanfa Zou

    Citation: Clinical Proteomics 2014 11:26

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  34. Content type: Research

    Glycoproteins comprise a large portion of the salivary proteome and have great potential for biomarker discovery and disease diagnosis. However, the rate of production and the concentration of whole saliva cha...

    Authors: Shisheng Sun, Fei Zhao, Qinzhe Wang, Yaogang Zhong, Tanxi Cai, Peng Wu, Fuquan Yang and Zheng Li

    Citation: Clinical Proteomics 2014 11:25

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  35. Content type: Research

    Histone post-translational modifications (PTMs) play an important role in the regulation of the expression of genes, including those involved in cancer development and progression. However, our knowledge of PT...

    Authors: Jakub Karczmarski, Tymon Rubel, Agnieszka Paziewska, Michal Mikula, Mateusz Bujko, Paulina Kober, Michal Dadlez and Jerzy Ostrowski

    Citation: Clinical Proteomics 2014 11:24

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  36. Content type: Research

    Ovarian cancer (OvCa) is the most lethal gynecological malignancy. The emergence of high-throughput technologies, such as mass spectrometry, has allowed for a paradigm shift in the way we search for novel biom...

    Authors: Christopher R Smith, Ihor Batruch, Josep Miquel Bauça, Hari Kosanam, Julia Ridley, Marcus Q Bernardini, Felix Leung, Eleftherios P Diamandis and Vathany Kulasingam

    Citation: Clinical Proteomics 2014 11:23

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  37. Content type: Review

    Protein glycosylation, as an important post-translational modification, is implicated in a number of ailments. Applying proteomic approaches, including mass spectrometry (MS) analyses that have played a signif...

    Authors: Hu Zhao, Yaojun Li and Ye Hu

    Citation: Clinical Proteomics 2014 11:21

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  38. Content type: Research

    Adipose tissue is both an energy storage depot and an endocrine organ. The impaired regulation of the secreted proteins of adipose tissue, known as adipocytokines, observed during obesity contributes to the on...

    Authors: Jae-Min Lim, Edith E Wollaston-Hayden, Chin Fen Teo, Dorothy Hausman and Lance Wells

    Citation: Clinical Proteomics 2014 11:20

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  39. Content type: Research

    Estrogen has been shown to mediate protection in female hearts against ischemia-reperfusion (I-R) stress. Composed by a Kir6.2 pore and an SUR2 regulatory subunit, cardiac ATP-sensitive potassium channels (KAT...

    Authors: Jianjiong Gao, Dong Xu, Grzegorz Sabat, Hector Valdivia, Wei Xu and Nian-Qing Shi

    Citation: Clinical Proteomics 2014 11:19

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  40. Content type: Research

    Peritoneal dialysis (PD) is a form of renal replacement used for advanced chronic kidney disease. PD effluent holds a great potential for biomarker discovery for diagnosis and prognosis. In this study a novel ...

    Authors: Elisabete Oliveira, José E Araújo, Silvana Gómez-Meire, Carlos Lodeiro, Cristina Perez-Melon, Elena Iglesias-Lamas, Alfonso Otero-Glez, José L Capelo and Hugo M Santos

    Citation: Clinical Proteomics 2014 11:17

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  41. Content type: Review

    Gel- based proteomics is one of the most versatile methods for fractionating protein complexes. Among these methods, two dimensional- polyacrylamide gel electrophoresis (2-DE) represents a mainstay orthogonal ...

    Authors: Sameh Magdeldin, Shymaa Enany, Yutaka Yoshida, Bo Xu, Ying Zhang, Zam Zureena, Ilambarthi Lokamani, Eishin Yaoita and Tadashi Yamamoto

    Citation: Clinical Proteomics 2014 11:16

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  42. Content type: Review

    Protein glycosylation serves critical roles in the cellular and biological processes of many organisms. Aberrant glycosylation has been associated with many illnesses such as hereditary and chronic diseases li...

    Authors: Deniz Baycin Hizal, Daniel Wolozny, Joseph Colao, Elena Jacobson, Yuan Tian, Sharon S Krag, Michael J Betenbaugh and Hui Zhang

    Citation: Clinical Proteomics 2014 11:15

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  43. Content type: Review

    Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associate...

    Authors: Huan Liu, Ningbo Zhang, Debin Wan, Meng Cui, Zhiqiang Liu and Shuying Liu

    Citation: Clinical Proteomics 2014 11:14

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  44. Content type: Research

    Conventional proteomic approaches have thus far been unable to identify novel serum biomarkers for ovarian cancer that are more sensitive and specific than the current clinically used marker, CA-125. Because e...

    Authors: Anand Bery, Felix Leung, Christopher R Smith, Eleftherios P Diamandis and Vathany Kulasingam

    Citation: Clinical Proteomics 2014 11:13

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  45. Content type: Research

    Transthyretin (TTR), an abundant protein in cerebrospinal fluid (CSF), contains a free, oxidation-prone cysteine residue that gives rise to TTR isoforms. These isoforms may reflect conditions in vivo. Since incre...

    Authors: Keld Poulsen, Justyna MC Bahl, Anja H Simonsen, Steen G Hasselbalch and Niels HH Heegaard

    Citation: Clinical Proteomics 2014 11:12

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  46. Content type: Research

    It is well known that cell surface glycans or glycocalyx play important roles in sperm motility, maturation and fertilization. A comprehensive profile of the sperm surface glycans will greatly facilitate both ...

    Authors: Ai-Jie Xin, Li Cheng, Hua Diao, Peng Wang, Yi-Hua Gu, Bin Wu, Yan-Cheng Wu, Guo-Wu Chen, Shu-Min Zhou, Shu-Juan Guo, Hui-Juan Shi and Sheng-Ce Tao

    Citation: Clinical Proteomics 2014 11:10

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