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Clinical Proteomics


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  1. Content type: Research

    Kallikrein 9 (KLK9) is a member of the human kallikrein-related peptidases family, whose physiological role and implications in disease processes remain unclear. The active form of the enzyme is predicted to h...

    Authors: Panagiota Filippou, Dimitrios Korbakis, Sofia Farkona, Antoninus Soosaipillai, Theano Karakosta and Eleftherios P. Diamandis

    Citation: Clinical Proteomics 2017 14:4

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  2. Content type: Research

    Glycans play critical roles in a number of biological activities. Two common types of glycans, N-linked and O-linked, have been extensively analyzed in the last decades. N-glycans are typically released from g...

    Authors: Shuang Yang, Naseruddin Höti, Weiming Yang, Yang Liu, Lijun Chen, Shuwei Li and Hui Zhang

    Citation: Clinical Proteomics 2017 14:3

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  3. Content type: Research

    sIgE and sIgG4 detection is necessary for more accurate and effective type I hypersensitivity diagnostics and the estimation of disease development. Typically, the analyses of these antibodies are performed se...

    Authors: Guzel Feyzkhanova, Sergei Voloshin, Olga Smoldovskaya, Alla Arefieva, Marina Filippova, Viktor Barsky, Ludmila Pavlushkina, Veronika Butvilovskaya, Alexei Tikhonov, Yuri Reznikov and Alla Rubina

    Citation: Clinical Proteomics 2017 14:1

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  4. Content type: Research

    Autism is a severe childhood neurological disorder with poorly understood etiology and pathology. Currently, there is no authentic laboratory test to confirm the diagnosis of autism. Oxidative damage may play ...

    Authors: Chengyun Feng, Youjiao Chen, Jintao Pan, Aochu Yang, Li Niu, Jie Min, Xianling Meng, Liping Liao, Kaoyuan Zhang and Liming Shen

    Citation: Clinical Proteomics 2017 14:2

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  5. Content type: Review

    Proteomics plays an increasingly important role in our quest to understand cardiovascular biology. Fueled by analytical and computational advances in the past decade, proteomics applications can now go beyond ...

    Authors: Maggie P. Y. Lam, Edward Lau, Dominic C. M. Ng, Ding Wang and Peipei Ping

    Citation: Clinical Proteomics 2016 13:23

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  6. Content type: Research

    Excretory-secretory (ES) proteins of E. histolytica are thought to play important roles in the host invasion, metabolism, and defence. Elucidation of the types and functions of E. histolytica ES proteins can furt...

    Authors: Jorim Anak Ujang, Soon Hong Kwan, Mohd Nazri Ismail, Boon Huat Lim, Rahmah Noordin and Nurulhasanah Othman

    Citation: Clinical Proteomics 2016 13:33

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  7. Content type: Research

    High quality clinical samples are critical for meaningful interpretation of data obtained in both basic and translational medicine. More specifically, optimized pre-analysis handling to bio-sample is crucial ...

    Authors: Kai Liang, Hongmei Wu, Tony Y. Hu and Yan Li

    Citation: Clinical Proteomics 2016 13:34

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  8. Content type: Research

    Ovarian cancer is the most lethal gynecological malignancy due to its frequent recurrence and drug resistance even after successful initial treatment. Accumulating scientific evidence indicates that subpopulat...

    Authors: Ran Zhao, Xiaoxia Liu, Yisheng Wang, Xiaoxiang Jie, Ruihuan Qin, Wenjun Qin, Mengyu Zhang, Haiyan Tai, Caiting Yang, Lili Li, Peike Peng, Miaomiao Shao, Xingwang Zhang, Hao Wu, Yuanyuan Ruan, Congjian Xu…

    Citation: Clinical Proteomics 2016 13:32

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  9. Content type: Review

    Proteomics has emerged as a highly promising bioanalytical technique in various aspects of applied biological research. In Indian academia, proteomics research has grown remarkably over the last decade. It is ...

    Authors: Somaditya Mukherjee and Arun Bandyopadhyay

    Citation: Clinical Proteomics 2016 13:21

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  10. Content type: Research

    Lung cancer is the leading cause of cancer mortality in the United States. Non-small cell lung cancer accounts for 85% of all lung cancers for which adenocarcinoma is the most common histological type. Managem...

    Authors: Johannes F. Fahrmann, Dmitry Grapov, Brett S. Phinney, Carol Stroble, Brian C. DeFelice, William Rom, David R. Gandara, Yanhong Zhang, Oliver Fiehn, Harvey Pass and Suzanne Miyamoto

    Citation: Clinical Proteomics 2016 13:31

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  11. Content type: Research

    Correct identification of the amyloidosis-causing protein is crucial for clinical management. Recently the Mayo Clinic reported laser-capture microdissection (LCM) with liquid chromatography-coupled tandem mas...

    Authors: Peter Mollee, Samuel Boros, Dorothy Loo, Jayde E. Ruelcke, Vanessa A. Lakis, Kim-Anh Lê Cao, Patricia Renaut and Michelle M. Hill

    Citation: Clinical Proteomics 2016 13:30

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  12. Content type: Research

    Retinoblastoma is an ocular neoplastic cancer caused primarily due to the mutation/deletion of RB1 gene. Due to the rarity of the disease very limited information is available on molecular changes in primary r...

    Authors: Ravikanth Danda, Kalaivani Ganapathy, Gajanan Sathe, Anil K. Madugundu, Sharavan Ramachandran, Uma Maheswari Krishnan, Vikas Khetan, Pukhraj Rishi, T. S. Keshava Prasad, Akhilesh Pandey, Subramanian Krishnakumar, Harsha Gowda and Sailaja V. Elchuri

    Citation: Clinical Proteomics 2016 13:29

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  13. Content type: Research

    Early recurrence after surgical resection is a hallmark of poor prognosis in hepatocellular carcinoma (HCC). To determine the proteomic background of early recurrence of HCC, we focused on apoptosis-related pr...

    Authors: Noriaki Morofuji, Hidenori Ojima, Nobuyoshi Hiraoka, Takuji Okusaka, Minoru Esaki, Satoshi Nara, Kazuaki Shimada, Yoshiro Kishi and Tadashi Kondo

    Citation: Clinical Proteomics 2016 13:28

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  14. Content type: Research

    Diabetic nephropathy (DN) is a late complication in both type 1 diabetes mellitus (T1DM) and T2DM. Already at an early stage of DN morphological changes occur at the cell surface and in the extracellular matri...

    Authors: Leena Liljedahl, Maiken Højgaard Pedersen, Jenny Norlin, James N. McGuire and Peter James

    Citation: Clinical Proteomics 2016 13:22

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  15. Content type: Research

    Fibrinogen alpha C chain 5.9 kDa fragment (FIC5.9) is a new serum biomarker for chronic hepatitis that was discovered by proteomics analysis. Previous studies have shown that FIC5.9 is derived from the C-termi...

    Authors: Wataru Kikuchi, Motoi Nishimura, Takahisa Kuga, Sachio Tsuchida, Tatsuya Saito, Mamoru Satoh, Kenta Noda, Yoshio Kodera, Takeshi Tomonaga and Fumio Nomura

    Citation: Clinical Proteomics 2016 13:27

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  16. Content type: Review

    Disease progression and drug response may vary significantly from patient to patient. Fortunately, the rapid development of high-throughput ‘omics’ technologies has allowed for the identification of potential ...

    Authors: Allison B. Chambliss and Daniel W. Chan

    Citation: Clinical Proteomics 2016 13:25

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  17. Content type: Research

    The successful application of—omics technologies in the discovery of novel biomarkers and targets of therapeutic interventions is facilitated by large collections of well curated clinical samples stored in bio...

    Authors: Maria Kaisar, Leon F. A. van Dullemen, Marie-Laëtitia Thézénas, M. Zeeshan Akhtar, Honglei Huang, Sandrine Rendel, Philip D. Charles, Roman Fischer, Rutger J. Ploeg and Benedikt M. Kessler

    Citation: Clinical Proteomics 2016 13:26

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  18. Content type: Research

    Non-invasive monitoring of liver disease remains an important health issue. Liver secreted glycoproteins reflect pathophysiological states of the organ and represent a rational target for serologic monitoring....

    Authors: Miloslav Sanda, Julius Benicky, Jing Wu, Yiwen Wang, Kepher Makambi, Jaeil Ahn, Coleman I. Smith, Peng Zhao, Lihua Zhang and Radoslav Goldman

    Citation: Clinical Proteomics 2016 13:24

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  19. Content type: Review

    Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of cardiac wound healing responses that involve stimulation of robust inflammation to clear necrotic myocytes and tissue debris...

    Authors: Merry L. Lindsey, Michael E. Hall, Romain Harmancey and Yonggang Ma

    Citation: Clinical Proteomics 2016 13:19

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  20. Content type: Research

    Ebola virus like particles (EBOV VLPs, eVLPs), are produced by expressing the viral transmembrane glycoprotein (GP) and structural matrix protein VP40 in mammalian cells. When expressed, these proteins self-a...

    Authors: Lisa H. Cazares, Michael D. Ward, Ernst E. Brueggemann, Tara Kenny, Paul Demond, Christopher R. Mahone, Karen A. O. Martins, Jonathan E. Nuss, Trevor Glaros and Sina Bavari

    Citation: Clinical Proteomics 2016 13:18

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  21. Content type: Research

    The urinary proteome of patients undergoing cardiopulmonary bypass (CPB) may provide important insights into systemic and renal changes associated with the procedure. Such information may ultimately provide a ...

    Authors: Ravi C. Dwivedi, Mario Navarrete, Nora Choi, Victor Spicer, Claudio Rigatto, Rakesh C. Arora, Oleg Krokhin, Julie Ho and John A. Wilkins

    Citation: Clinical Proteomics 2016 13:17

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  22. Content type: Research

    Angiotensin-II (Ang II) mediates progression of autosomal-dominant polycystic kidney disease (ADPKD) and other chronic kidney diseases (CKD). However, markers of kidney Ang II activity are lacking. We previous...

    Authors: Ana Konvalinka, Ihor Batruch, Tomas Tokar, Apostolos Dimitromanolakis, Shelby Reid, Xuewen Song, York Pei, Andrei P. Drabovich, Eleftherios P. Diamandis, Igor Jurisica and James W. Scholey

    Citation: Clinical Proteomics 2016 13:16

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  23. Content type: Research

    An early, reliable and noninvasive method of early pregnancy diagnosis is prerequisite for efficient reproductive management in dairy industry. The early detection of pregnancy also help in to reduce the calvi...

    Authors: Preeti Rawat, Shveta Bathla, Rubina Baithalu, Munna Lal Yadav, Sudarshan Kumar, Syed Azamal Ali, Anurag Tiwari, Masoud Lotfan, Jasmine Naru, Manoj Jena, Pradip Behere, Ashok K. Balhara, Rajesh Vashisth, Inderjeet Singh, Ajay Dang, Jai K. Kaushik…

    Citation: Clinical Proteomics 2016 13:15

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  24. Content type: Research

    The refractory nature of many cancers remains the main health challenge over the past century. The epigenetic drug, decitabine (DAC), represents one of the most promising therapeutic agents in cancers particul...

    Authors: Chunchao Zhang, Jinfeng Suo, Hiroyuki Katayama, Yue Wei, Guillermo Garcia-Manero and Samir Hanash

    Citation: Clinical Proteomics 2016 13:14

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