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  1. Vulvar squamous cell carcinoma (vSCC) is a rare but debilitating disease. One vSCC variant comprises tumor cells that grow and expand as a cohesive sheet of cells that “pushes” and compresses the associated ly...

    Authors: Emily R. Holthoff, Stephanie D. Byrum, Samuel G. Mackintosh, Thomas Kelly, Alan J. Tackett, Charles M. Quick and Steven R. Post

    Citation: Clinical Proteomics 2017 14:40

    Content type: Research

    Published on:

  2. The tryptic peptides from ice cold versus room temperature plasma were identified by C18 liquid chromatography and micro electrospray ionization tandem mass spectrometry (LC–ESI–MS/MS). Samples collected on ic...

    Authors: Jaimie Dufresne, Angelique Florentinus-Mefailoski, Juliet Ajambo, Ammara Ferwa, Peter Bowden and John Marshall

    Citation: Clinical Proteomics 2017 14:39

    Content type: Research

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  3. It is well known that fibrin network binds a large variety of proteins, including inhibitors and activators of fibrinolysis, which may affect clot properties, such as stability and susceptibility to fibrinolys...

    Authors: Aneta Stachowicz, Jakub Siudut, Maciej Suski, Rafał Olszanecki, Ryszard Korbut, Anetta Undas and Jacek R. Wiśniewski

    Citation: Clinical Proteomics 2017 14:38

    Content type: Research

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  4. Idiopathic macular holes (IMH) are full-thickness defects of retinal tissue that cause severe vision loss due to disruption of the anatomic fovea. Abnormal vitreous traction is involved in the formation of mac...

    Authors: Pingbo Zhang, Min Zhu, Yuming Zhao, Jiang Qian, Craig Dufresne, Randi Turner, Richard D. Semba and Sharon D. Solomon

    Citation: Clinical Proteomics 2017 14:37

    Content type: Research

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  5. Bovine purified protein derivative (bPPD) and avian purified protein derivative (aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about their qualitative and quantitative chara...

    Authors: José Antonio Infantes-Lorenzo, Inmaculada Moreno, María de los Ángeles Risalde, Álvaro Roy, Margarita Villar, Beatriz Romero, Nieves Ibarrola, José de la Fuente, Eugenia Puentes, Lucía de Juan, Christian Gortázar, Javier Bezos, Lucas Domínguez and Mercedes Domínguez

    Citation: Clinical Proteomics 2017 14:36

    Content type: Research

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  6. Thirty human EDTA plasma samples from male and female subjects ranging in age from 24 to 74 years were collected on ice, processed ice cold and stored frozen at −80 °C, in liquid nitrogen (LN2), or freeze dri...

    Authors: Jaimie Dufresne, Trung Hoang, Juliet Ajambo, Angelique Florentinus-Mefailoski, Peter Bowden and John Marshall

    Citation: Clinical Proteomics 2017 14:35

    Content type: Research

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  7. Currently, there are no FDA approved screening tools for detecting early stage ovarian cancer in the general population. Development of a biomarker-based assay for early detection would significantly improve t...

    Authors: Kristin L. M. Boylan, Kate Geschwind, Joseph S. Koopmeiners, Melissa A. Geller, Timothy K. Starr and Amy P. N. Skubitz

    Citation: Clinical Proteomics 2017 14:34

    Content type: Research

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  8. Cancer associated fibroblasts are activated in the tumor microenvironment and contribute to tumor progression, angiogenesis, extracellular matrix remodeling, and inflammation.

    Authors: Daniel Drev, Andrea Bileck, Zeynep N. Erdem, Thomas Mohr, Gerald Timelthaler, Andrea Beer, Christopher Gerner and Brigitte Marian

    Citation: Clinical Proteomics 2017 14:33

    Content type: Research

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  9. Systemic lupus erythematosus (SLE) is a remarkably heterogeneous autoimmune disease. Despite tremendous efforts, our knowledge of serum protein patterns in severe SLE phenotypes is still limited. We investigat...

    Authors: Anna Petrackova, Andrea Smrzova, Petr Gajdos, Marketa Schubertova, Petra Schneiderova, Pavel Kromer, Vaclav Snasel, Martina Skacelova, Frantisek Mrazek, Josef Zadrazil, Pavel Horak and Eva Kriegova

    Citation: Clinical Proteomics 2017 14:32

    Content type: Research

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  10. Non-small cell lung carcinoma (NSCLC) remains the leading cause of cancer deaths in the United States. More than half of NSCLC patients have clinical presentations with locally advanced or metastatic disease a...

    Authors: Shuang Yang, Lijun Chen, Daniel W. Chan, Qing Kay Li and Hui Zhang

    Citation: Clinical Proteomics 2017 14:31

    Content type: Research

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  11. The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with pro...

    Authors: Teodora Ioana Flavia Paunas, Kenneth Finne, Sabine Leh, Hans-Peter Marti, Tom Eirik Mollnes, Frode Berven and Bjørn Egil Vikse

    Citation: Clinical Proteomics 2017 14:30

    Content type: Research

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  12. Hepatocellular carcinoma is an aggressive malignancy with poor prognosis and easy to recur even the tumor is totally removed by surgery. Portal vascular invasion is one of the major factors contributing to tum...

    Authors: Wei-Chen Lee, Hong-Shiue Chou, Ting-Jung Wu, Chen-Fang Lee, Pao-Yueh Hsu, Hsiu-Ying Hsu, Tsung-Han Wu and Kun-Ming Chan

    Citation: Clinical Proteomics 2017 14:29

    Content type: Research

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  13. The aim was to improve upon an existing blood-based colorectal cancer (CRC) test directed to high-risk symptomatic patients, by developing a new CRC classifier to be used with a new test embodiment. The new te...

    Authors: Lisa J. Croner, Roslyn Dillon, Athit Kao, Stefanie N. Kairs, Ryan Benz, Ib J. Christensen, Hans J. Nielsen, John E. Blume and Bruce Wilcox

    Citation: Clinical Proteomics 2017 14:28

    Content type: Research

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  14. Post-stroke infections occur in 20–36% of stroke patients and are associated with high morbidity and mortality rates. Early identification of patients at risk of developing an infection could improve care via ...

    Authors: L. Azurmendi, V. Lapierre-Fetaud, J. Schneider, J. Montaner, M. Katan and Jean-Charles Sanchez

    Citation: Clinical Proteomics 2017 14:27

    Content type: Research

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  15. Mesenchymal stem/stromal cells (MSC) display a range of immunoregulatory properties which can be enhanced by the exposure to cytokines such interferon γ (IFN-γ). However the compositional changes associated wi...

    Authors: Qingdong Guan, Peyman Ezzati, Victor Spicer, Oleg Krokhin, Donna Wall and John A. Wilkins

    Citation: Clinical Proteomics 2017 14:26

    Content type: Research

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  16. The number of pulmonary nodules detected in the US is expected to increase substantially following recent recommendations for nationwide CT-based lung cancer screening. Given the low specificity of CT screenin...

    Authors: Charles E. Birse, Jennifer L. Tomic, Harvey I. Pass, William N. Rom and Robert J. Lagier

    Citation: Clinical Proteomics 2017 14:25

    Content type: Research

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  18. The pathogenesis of systemic lupus erythematosus (SLE) is poorly understood but has been linked to defective clearance of subcellular particulate material from the circulation. This study investigates the orig...

    Authors: Ole Østergaard, Christoffer Tandrup Nielsen, Julia T. Tanassi, Line V. Iversen, Søren Jacobsen and Niels H. H. Heegaard

    Citation: Clinical Proteomics 2017 14:23

    Content type: Research

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  19. Atherosclerotic plaque rupture is the culprit event which underpins most acute vascular syndromes such as acute myocardial infarction. Novel biomarkers of plaque rupture could improve biological understanding...

    Authors: Regent Lee, Roman Fischer, Philip D. Charles, David Adlam, Alessandro Valli, Katalin Di Gleria, Rajesh K. Kharbanda, Robin P. Choudhury, Charalambos Antoniades, Benedikt M. Kessler and Keith M. Channon

    Citation: Clinical Proteomics 2017 14:22

    Content type: Research

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  20. Mycobacterium tuberculosis (Mtb) is the causative agent of Tuberculosis (TB), the number one cause of death due to an infectious disease. TB diagnosis is performed by microscopy, cultu...

    Authors: Carolina Mehaffy, Karen M. Dobos, Payam Nahid and Nicole A. Kruh-Garcia

    Citation: Clinical Proteomics 2017 14:21

    Content type: Research

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  21. Ovarian cancer is one of the most lethal gynecological malignancies, in which platinum resistance is a common cause of its relapse and death. Glycosylation has been reported to be involved in drug resistance, ...

    Authors: Ran Zhao, Wenjun Qin, Ruihuan Qin, Jing Han, Can Li, Yisheng Wang and Congjian Xu

    Citation: Clinical Proteomics 2017 14:20

    Content type: Research

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  22. The Xiaoke Pill containing Chinese herb extracts and Glibenclamide, is used in therapy for type 2 diabetes mellitus (T2DM), and is effective in reducing the risk of hypoglycemia and improving diabetes symptoms...

    Authors: Xiuying Zhang, Haidan Sun, Sanjoy K. Paul, Quanhui Wang, Xiaomin Lou, Guixue Hou, Bo Wen, Linong Ji and Siqi Liu

    Citation: Clinical Proteomics 2017 14:19

    Content type: Research

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  23. Nephrotic syndrome (NS) is a nonspecific kidney disorder, commonly caused by minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN). Here we analyzed urinary p...

    Authors: Young Wook Choi, Yang Gyun Kim, Min-Young Song, Ju-Young Moon, Kyung-Hwan Jeong, Tae-Won Lee, Chun-Gyoo Ihm, Kang-Sik Park and Sang-Ho Lee

    Citation: Clinical Proteomics 2017 14:18

    Content type: Research

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  24. To develop a new molecular targeted treatment for brain (AVMs), identification of membrane proteins that are localised on the AVM endothelium is crucial. Current treatment methods are surgery and radiosurgery....

    Authors: Margaret Simonian, Rachel R. Ogorzalek Loo, Nalaka Rannulu, Joseph A. Loo, Mark P. Molloy and Marcus A. Stoodley

    Citation: Clinical Proteomics 2017 14:17

    Content type: Research

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  25. Epithelial ovarian carcinomas encompass a heterogeneous group of diseases with a poor 5-year survival rate. Serous carcinoma is the most common type. Most FDA-approved serum tumor markers are glycoproteins. Th...

    Authors: Qing Kay Li, Punit Shah, Yuan Tian, Yingwei Hu, Richard B. S. Roden, Hui Zhang and Daniel W. Chan

    Citation: Clinical Proteomics 2017 14:16

    Content type: Research

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  26. Aberrant expression of Na+/K+-ATPase α1 subunit (ATP1A1) is widely observed in multiple types of tumors, and its tissue-specific expression relates to cancer development. However, the functions and molecular mech...

    Authors: Dan Zhang, Peng Zhang, Pengbo Yang, Yu He, Xixi Wang, Yanfang Yang, Hongxia Zhu, Ningzhi Xu and Shufang Liang

    Citation: Clinical Proteomics 2017 14:15

    Content type: Research

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  27. The systematic mechanisms of acute intracerebral hemorrhage are still unknown and unverified, although many recent researches have indicated the secondary insults. This study was aimed to disclose the patholog...

    Authors: Guo-chun Li, Lina Zhang, Ming Yu, Haiyu Jia, Ting Tian, Junqin Wang, Fuqiang Wang and Ling Zhou

    Citation: Clinical Proteomics 2017 14:14

    Content type: Research

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  28. X-linked retinoschisis (XLRS) is a vitreoretinal degenerative disorder causing vision deterioration, due to structural defects in retina. The hallmark of this disease includes radial streaks arising from the f...

    Authors: Dhandayuthapani Sudha, Mahdokht Kohansal-Nodehi, Purnima Kovuri, Srikanth Srinivas Manda, Srividya Neriyanuri, Lingam Gopal, Pramod Bhende, Subbulakshmi Chidambaram and Jayamuruga Pandian Arunachalam

    Citation: Clinical Proteomics 2017 14:13

    Content type: Research

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  29. Calcific aortic stenosis (CAS) is the most common heart valve disease in the elderly, representing an important economic and social burden in developed countries. Currently, there is no way to predict either t...

    Authors: Tatiana Martin-Rojas, Laura Mourino-Alvarez, Felix Gil-Dones, Fernando de la Cuesta, Esther Rosello-Lleti, Carlos M. Laborde, Miguel Rivera, Luis Fernando Lopez-Almodovar, Juan Antonio Lopez, Finn Akerstrom, Luis R. Padial and Maria G. Barderas

    Citation: Clinical Proteomics 2017 14:12

    Content type: Research

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  30. Subcellular microvesicles (MVs) have attracted increasing interest during the past decades. While initially considered as inert cellular debris, several important roles for MVs in physiological homeostasis, ca...

    Authors: Christoffer T. Nielsen, Ole Østergaard, Niclas S. Rasmussen, Søren Jacobsen and Niels H. H. Heegaard

    Citation: Clinical Proteomics 2017 14:11

    Content type: Review

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  31. Recent epidemiological studies indicate that only 30–50% of undiagnosed type 2 diabetes mellitus (T2DM) patients are identified using glycated hemoglobin (HbA1c) and elevated fasting plasma glucose (FPG) levels. ...

    Authors: Sandro Spiller, Yichao Li, Matthias Blüher, Lonnie Welch and Ralf Hoffmann

    Citation: Clinical Proteomics 2017 14:10

    Content type: Research

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  32. Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is imp...

    Authors: Florence Quesada-Calvo, Charlotte Massot, Virginie Bertrand, Rémi Longuespée, Noëlla Blétard, Joan Somja, Gabriel Mazzucchelli, Nicolas Smargiasso, Dominique Baiwir, Marie-Claire De Pauw-Gillet, Philippe Delvenne, Michel Malaise, Carla Coimbra Marques, Marc Polus, Edwin De Pauw, Marie-Alice Meuwis…

    Citation: Clinical Proteomics 2017 14:9

    Content type: Research

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  33. Tubulointerstitial nephritis antigen-like 1 protein (TINAGL1), is a matricellular protein, known to play role in cell adhesion and cell receptor interaction. Research related to TINAGL1 is limited to cell cult...

    Authors: Sheon Mary, Mahesh J. Kulkarni, Savita S. Mehendale, Sadhana R. Joshi and Ashok P. Giri

    Citation: Clinical Proteomics 2017 14:8

    Content type: Research

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  34. Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 7–10% of women of reproductive ...

    Authors: Giuseppe Grande, Federica Vincenzoni, Domenico Milardi, Giuseppina Pompa, Domenico Ricciardi, Erika Fruscella, Francesca Mancini, Alfredo Pontecorvi, Massimo Castagnola and Riccardo Marana

    Citation: Clinical Proteomics 2017 14:7

    Content type: Research

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  35. Nasopharyngeal carcinoma (NPC) is a major head and neck cancer with high occurrence in Southeast Asia and southern China. We aimed to identify autoantibodies that may contribute to early detection of NPC.

    Authors: Lie-Hao Lin, Yi-Wei Xu, Li-Sheng Huang, Chao-Qun Hong, Tian-Tian Zhai, Lian-Di Liao, Wen-Jie Lin, Li-Yan Xu, Kai Zhang, En-Min Li and Yu-Hui Peng

    Citation: Clinical Proteomics 2017 14:6

    Content type: Research

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  37. Kallikrein 9 (KLK9) is a member of the human kallikrein-related peptidases family, whose physiological role and implications in disease processes remain unclear. The active form of the enzyme is predicted to h...

    Authors: Panagiota Filippou, Dimitrios Korbakis, Sofia Farkona, Antoninus Soosaipillai, Theano Karakosta and Eleftherios P. Diamandis

    Citation: Clinical Proteomics 2017 14:4

    Content type: Research

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  38. Glycans play critical roles in a number of biological activities. Two common types of glycans, N-linked and O-linked, have been extensively analyzed in the last decades. N-glycans are typically released from g...

    Authors: Shuang Yang, Naseruddin Höti, Weiming Yang, Yang Liu, Lijun Chen, Shuwei Li and Hui Zhang

    Citation: Clinical Proteomics 2017 14:3

    Content type: Research

    Published on:

    The Related Article to this article has been published in Nature Protocols 2017 12:BFnprot2017034

  39. Autism is a severe childhood neurological disorder with poorly understood etiology and pathology. Currently, there is no authentic laboratory test to confirm the diagnosis of autism. Oxidative damage may play ...

    Authors: Chengyun Feng, Youjiao Chen, Jintao Pan, Aochu Yang, Li Niu, Jie Min, Xianling Meng, Liping Liao, Kaoyuan Zhang and Liming Shen

    Citation: Clinical Proteomics 2017 14:2

    Content type: Research

    Published on:

  40. sIgE and sIgG4 detection is necessary for more accurate and effective type I hypersensitivity diagnostics and the estimation of disease development. Typically, the analyses of these antibodies are performed se...

    Authors: Guzel Feyzkhanova, Sergei Voloshin, Olga Smoldovskaya, Alla Arefieva, Marina Filippova, Viktor Barsky, Ludmila Pavlushkina, Veronika Butvilovskaya, Alexei Tikhonov, Yuri Reznikov and Alla Rubina

    Citation: Clinical Proteomics 2017 14:1

    Content type: Research

    Published on:

  41. Proteomics plays an increasingly important role in our quest to understand cardiovascular biology. Fueled by analytical and computational advances in the past decade, proteomics applications can now go beyond ...

    Authors: Maggie P. Y. Lam, Edward Lau, Dominic C. M. Ng, Ding Wang and Peipei Ping

    Citation: Clinical Proteomics 2016 13:23

    Content type: Review

    Published on:

  42. High quality clinical samples are critical for meaningful interpretation of data obtained in both basic and translational medicine. More specifically, optimized pre-analysis handling to bio-sample is crucial ...

    Authors: Kai Liang, Hongmei Wu, Tony Y. Hu and Yan Li

    Citation: Clinical Proteomics 2016 13:34

    Content type: Research

    Published on:

  43. Excretory-secretory (ES) proteins of E. histolytica are thought to play important roles in the host invasion, metabolism, and defence. Elucidation of the types and functions of E. histolytica ES proteins can furt...

    Authors: Jorim Anak Ujang, Soon Hong Kwan, Mohd Nazri Ismail, Boon Huat Lim, Rahmah Noordin and Nurulhasanah Othman

    Citation: Clinical Proteomics 2016 13:33

    Content type: Research

    Published on:

  44. Ovarian cancer is the most lethal gynecological malignancy due to its frequent recurrence and drug resistance even after successful initial treatment. Accumulating scientific evidence indicates that subpopulat...

    Authors: Ran Zhao, Xiaoxia Liu, Yisheng Wang, Xiaoxiang Jie, Ruihuan Qin, Wenjun Qin, Mengyu Zhang, Haiyan Tai, Caiting Yang, Lili Li, Peike Peng, Miaomiao Shao, Xingwang Zhang, Hao Wu, Yuanyuan Ruan, Congjian Xu…

    Citation: Clinical Proteomics 2016 13:32

    Content type: Research

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  45. Proteomics has emerged as a highly promising bioanalytical technique in various aspects of applied biological research. In Indian academia, proteomics research has grown remarkably over the last decade. It is ...

    Authors: Somaditya Mukherjee and Arun Bandyopadhyay

    Citation: Clinical Proteomics 2016 13:21

    Content type: Review

    Published on:

  46. Lung cancer is the leading cause of cancer mortality in the United States. Non-small cell lung cancer accounts for 85% of all lung cancers for which adenocarcinoma is the most common histological type. Managem...

    Authors: Johannes F. Fahrmann, Dmitry Grapov, Brett S. Phinney, Carol Stroble, Brian C. DeFelice, William Rom, David R. Gandara, Yanhong Zhang, Oliver Fiehn, Harvey Pass and Suzanne Miyamoto

    Citation: Clinical Proteomics 2016 13:31

    Content type: Research

    Published on:

  47. Correct identification of the amyloidosis-causing protein is crucial for clinical management. Recently the Mayo Clinic reported laser-capture microdissection (LCM) with liquid chromatography-coupled tandem mas...

    Authors: Peter Mollee, Samuel Boros, Dorothy Loo, Jayde E. Ruelcke, Vanessa A. Lakis, Kim-Anh Lê Cao, Patricia Renaut and Michelle M. Hill

    Citation: Clinical Proteomics 2016 13:30

    Content type: Research

    Published on:

  48. Retinoblastoma is an ocular neoplastic cancer caused primarily due to the mutation/deletion of RB1 gene. Due to the rarity of the disease very limited information is available on molecular changes in primary r...

    Authors: Ravikanth Danda, Kalaivani Ganapathy, Gajanan Sathe, Anil K. Madugundu, Sharavan Ramachandran, Uma Maheswari Krishnan, Vikas Khetan, Pukhraj Rishi, T. S. Keshava Prasad, Akhilesh Pandey, Subramanian Krishnakumar, Harsha Gowda and Sailaja V. Elchuri

    Citation: Clinical Proteomics 2016 13:29

    Content type: Research

    Published on:

  49. Early recurrence after surgical resection is a hallmark of poor prognosis in hepatocellular carcinoma (HCC). To determine the proteomic background of early recurrence of HCC, we focused on apoptosis-related pr...

    Authors: Noriaki Morofuji, Hidenori Ojima, Nobuyoshi Hiraoka, Takuji Okusaka, Minoru Esaki, Satoshi Nara, Kazuaki Shimada, Yoshiro Kishi and Tadashi Kondo

    Citation: Clinical Proteomics 2016 13:28

    Content type: Research

    Published on:

  50. Diabetic nephropathy (DN) is a late complication in both type 1 diabetes mellitus (T1DM) and T2DM. Already at an early stage of DN morphological changes occur at the cell surface and in the extracellular matri...

    Authors: Leena Liljedahl, Maiken Højgaard Pedersen, Jenny Norlin, James N. McGuire and Peter James

    Citation: Clinical Proteomics 2016 13:22

    Content type: Research

    Published on:

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Clinical Proteomics

ISSN: 1559-0275