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  1. Content type: Research

    Plasma renin activity (PRA) is an essential analytical tool for screening and diagnosis of secondary forms of hypertension. Typically, PRA is measured by competitive radioimmunoassay, but there are significant...

    Authors: Alexander G Camenzind, Jessica Grace van der Gugten, Robert Popp, Daniel T Holmes and Christoph H Borchers

    Citation: Clinical Proteomics 2013 10:20

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  2. Content type: Research

    Potential biomarkers to aid diagnosis and therapy need to be identified for Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The present study was designed to identify the fac...

    Authors: Anu Mary Varghese, Aparna Sharma, Poojashree Mishra, Kalyan Vijayalakshmi, Hindalahalli Chandregowda Harsha, Talakad N Sathyaprabha, Srinivas MM Bharath, Atchayaram Nalini, Phalguni Anand Alladi and Trichur R Raju

    Citation: Clinical Proteomics 2013 10:19

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  3. Content type: Research

    The rapid advancement of high-throughput tools for quantitative measurement of proteins has demonstrated the potential for the identification of proteins associated with cancer. However, the quantitative resul...

    Authors: Jing Chen, Shadi Toghi Eshghi, George Steven Bova, Qing Kay Li, Xingde Li and Hui Zhang

    Citation: Clinical Proteomics 2013 10:18

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  4. Content type: Research

    Serine hydrolases constitute a large enzyme family involved in a diversity of proteolytic and metabolic processes which are essential for many aspects of normal physiology. The roles of serine hydrolases in re...

    Authors: Mario Navarrete, Julie Ho, Oleg Krokhin, Peyman Ezzati, Claudio Rigatto, Martina Reslerova, David N Rush, Peter Nickerson and John A Wilkins

    Citation: Clinical Proteomics 2013 10:17

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  5. Content type: Research

    Serum biomarkers can improve diagnosis and treatment of malignant pleural mesothelioma (MPM). However, the evaluation of potential new serum biomarker candidates is hampered by a lack of assay technologies for...

    Authors: Ferdinando Cerciello, Meena Choi, Annalisa Nicastri, Damaris Bausch-Fluck, Annemarie Ziegler, Olga Vitek, Emanuela Felley-Bosco, Rolf Stahel, Ruedi Aebersold and Bernd Wollscheid

    Citation: Clinical Proteomics 2013 10:16

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  6. Content type: Research

    Lung cancer is the number one cause of cancer-related deaths in the United States and worldwide. The complex protein changes and/or signature of protein expression in lung cancer, particularly in non-small cel...

    Authors: Yan Li, Xiangchun Wang, MingHui Ao, Edward Gabrielson, Frederic Askin, Hui Zhang and Qing Kay Li

    Citation: Clinical Proteomics 2013 10:15

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  7. Content type: Research

    Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-stranded RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis and host...

    Authors: Vinuth N Puttamallesh, Sreelakshmi K Sreenivasamurthy, Pradeep Kumar Singh, H C Harsha, Anjali Ganjiwale, Shobha Broor, Akhilesh Pandey, Jayasuryan Narayana and T S Keshava Prasad

    Citation: Clinical Proteomics 2013 10:14

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  8. Content type: Research

    Arthritis refers to inflammation of joints and includes common disorders such as rheumatoid arthritis (RA) and spondyloarthropathies (SpAs). These diseases differ mainly in terms of their clinical manifestatio...

    Authors: Mitali Bhattacharjee, Rakesh Sharma, Renu Goel, Lavanya Balakrishnan, Santosh Renuse, Jayshree Advani, Shantal Tankala Gupta, Renu Verma, Sneha M Pinto, Nirujogi Raja Sekhar, Bipin Nair, T S Keshava Prasad, H C Harsha, Ramesh Jois, Subramanian Shankar and Akhilesh Pandey

    Citation: Clinical Proteomics 2013 10:11

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  9. Content type: Research

    To characterize changes in global protein expression in kidneys of transgenic rats overexpressing human selenoprotein M (SelM) in response to increased bioabivility of selenium (Sel), total proteins extracted ...

    Authors: Jun Seo Goo, Yo Na Kim, Kyung Mi Choi, In Sik Hwang, Ji Eun Kim, Young Ju Lee, Moon Hwa Kwak, Sun Bo Shim, Seung Wan Jee, Chul Joo Lim, Je Kyung Seong and Dae Youn Hwang

    Citation: Clinical Proteomics 2013 10:10

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  10. Content type: Research

    The ciliary body is the circumferential muscular tissue located just behind the iris in the anterior chamber of the eye. It plays a pivotal role in the production of aqueous humor, maintenance of the lens zonu...

    Authors: Renu Goel, Krishna R Murthy, Srinivas M Srikanth, Sneha M Pinto, Mitali Bhattacharjee, Dhanashree S Kelkar, Anil K Madugundu, Gourav Dey, Sujatha S Mohan, Venkatarangaiah Krishna, TS Keshava Prasad, Shukti Chakravarti, HC Harsha and Akhilesh Pandey

    Citation: Clinical Proteomics 2013 10:9

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  11. Content type: Research

    Purified protein derivative (PPD) has been used for more than half a century as an antigen for the diagnosis of tuberculosis infection based on delayed type hypersensitivity. Although designated as “purified,”...

    Authors: Thottethodi Subrahmanya Keshava Prasad, Renu Verma, Satish Kumar, Raja Sekhar Nirujogi, Gajanan J Sathe, Anil K Madugundu, Jyoti Sharma, Vinuth N Puttamallesh, Anjali Ganjiwale, Vithal P Myneedu, Aditi Chatterjee, Akhilesh Pandey, HC Harsha and Jayasuryan Narayana

    Citation: Clinical Proteomics 2013 10:8

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  12. Content type: Research

    Heart failure is a multifactorial disease associated with staggeringly high morbidity and motility. Recently, alterations of multiple metabolites have been implicated in heart failure; however, the lack of an ...

    Authors: CY X’avia Chan, Anjum A Khan, JH Howard Choi, CM Dominic Ng, Martin Cadeiras, Mario Deng and Peipei Ping

    Citation: Clinical Proteomics 2013 10:7

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  13. Content type: Research

    Complex molecular events lead to development and progression of liver cirrhosis to HCC. Differentially expressed nuclear membrane associated proteins are responsible for the functional and structural alteratio...

    Authors: Rizma Khan, Saadia Zahid, Yu-Jui Yvonne Wan, Jameson Forster, A-Bashar Abdul Karim, Atta M Nawabi, Abid Azhar, M Ataur Rahman and Nikhat Ahmed

    Citation: Clinical Proteomics 2013 10:6

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  14. Content type: Research

    Alzheimer’s disease (AD) is the most common type of dementia affecting people over 65 years of age. The hallmarks of AD are the extracellular deposits known as amyloid β plaques and the intracellular neurofibr...

    Authors: Ilijana Begcevic, Hari Kosanam, Eduardo Martínez-Morillo, Apostolos Dimitromanolakis, Phedias Diamandis, Uros Kuzmanov, Lili-Naz Hazrati and Eleftherios P Diamandis

    Citation: Clinical Proteomics 2013 10:5

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  15. Content type: Research

    Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with ac...

    Authors: Björg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn and Karin Sundfeldt

    Citation: Clinical Proteomics 2013 10:4

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  16. Content type: Research

    Rabies is a fatal acute viral disease of the central nervous system, which is a serious public health problem in Asian and African countries. Based on the clinical presentation, rabies can be classified into e...

    Authors: Abhilash K Venugopal, S Sameer Kumar Ghantasala, Lakshmi Dhevi N Selvan, Anita Mahadevan, Santosh Renuse, Praveen Kumar, Harsh Pawar, Nandini A Sahasrabhuddhe, Mooriyath S Suja, Yarappa L Ramachandra, Thottethodi S Keshava Prasad, Shampur N Madhusudhana, Harsha HC, Raghothama Chaerkady, Parthasarathy Satishchandra, Akhilesh Pandey…

    Citation: Clinical Proteomics 2013 10:3

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  17. Content type: Research

    Down syndrome (DS), caused by an extra copy of chromosome 21, affects 1 in 750 live births and is characterized by cognitive impairment and a constellation of congenital defects. Currently, little is known abo...

    Authors: Chan-Kyung J Cho, Andrei P Drabovich, George S Karagiannis, Eduardo Martínez-Morillo, Shawn Dason, Apostolos Dimitromanolakis and Eleftherios P Diamandis

    Citation: Clinical Proteomics 2013 10:2

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  18. Content type: Research

    In sickle cell disease (SCD), the mitogen-activated protein kinase (MAPK) ERK1/2 is constitutively active and can be inducible by agonist-stimulation only in sickle but not in normal human red blood cells (RBC...

    Authors: Erik J Soderblom, J Will Thompson, Evan A Schwartz, Edward Chiou, Laura G Dubois, M Arthur Moseley and Rahima Zennadi

    Citation: Clinical Proteomics 2013 10:1

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  19. Content type: Research

    We aimed to investigate the use of ovarian cyst fluid as a source for biomarker discovery and to find novel biomarkers for use in the diagnosis of epithelial ovarian tumors.

    Authors: Björg Kristjansdottir, Karolina Partheen, Eric T Fung, Janusz Marcickiewicz, Christine Yip, Mats Brännström and Karin Sundfeldt

    Citation: Clinical Proteomics 2012 9:14

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  20. Content type: Research

    Autosomal dominant polycystic kidney disease (ADPKD) is responsible for 10% of cases of the end stage renal disease. Early diagnosis, especially of potential fast progressors would be of benefit for efficient ...

    Authors: Magda Bakun, Mariusz Niemczyk, Dominik Domanski, Radek Jazwiec, Anna Perzanowska, Stanislaw Niemczyk, Michal Kistowski, Agnieszka Fabijanska, Agnieszka Borowiec, Leszek Paczek and Michal Dadlez

    Citation: Clinical Proteomics 2012 9:13

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  21. Content type: Research

    Tuberculous meningitis is a frequent extrapulmonary disease caused by Mycobacterium tuberculosis and is associated with high mortality rates and severe neurological sequelae. In an earlier study employing DNA mic...

    Authors: Ghantasala S Sameer Kumar, Abhilash K Venugopal, Anita Mahadevan, Santosh Renuse, H C Harsha, Nandini A Sahasrabuddhe, Harsh Pawar, Rakesh Sharma, Praveen Kumar, Sudha Rajagopalan, Keith Waddell, Yarappa L Ramachandra, Parthasarathy Satishchandra, Raghothama Chaerkady, T S Keshava Prasad, K Shankar…

    Citation: Clinical Proteomics 2012 9:12

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  22. Content type: Research

    Pathogenesis of liver damage in patients with HIV and HCV co-infection is complex and multifactorial. Although global awareness regarding HIV-1/HCV co-infection is increasing little is known about the pathophy...

    Authors: Nawal M Boukli, Vivekananda Shetty, Luis Cubano, Martha Ricaurte, Jordana Coelho-dos-Reis, Zacharie Nickens, Punit Shah, Andrew H Talal, Ramila Philip and Pooja Jain

    Citation: Clinical Proteomics 2012 9:11

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  23. Content type: Research

    In approximately 80% of patients, ovarian cancer is diagnosed when the patient is already in the advanced stages of the disease. CA125 is currently used as the marker for ovarian cancer; however, it lacks spec...

    Authors: Vivekananda Shetty, Julie Hafner, Punit Shah, Zacharie Nickens and Ramila Philip

    Citation: Clinical Proteomics 2012 9:10

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  24. Content type: Research

    Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS). It involves damage to the myelin sheath surrounding axons and to the axons themselves. MS most often presents with a...

    Authors: Yan Jia, Tianxia Wu, Christine A Jelinek, Bibiana Bielekova, Linda Chang, Scott Newsome, Sharmilee Gnanapavan, Gavin Giovannoni, Dawn Chen, Peter A Calabresi, Avindra Nath and Robert J Cotter

    Citation: Clinical Proteomics 2012 9:9

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  25. Content type: Meeting report

    A National Institutes of Health (NIH) workshop was convened in Bethesda, MD on September 26–27, 2011, with representative scientific leaders in the field of proteomics and its applications to clinical settings...

    Authors: Marc Vidal, Daniel W Chan, Mark Gerstein, Matthias Mann, Gilbert S Omenn, Danilo Tagle and Salvatore Sechi

    Citation: Clinical Proteomics 2012 9:6

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  26. Content type: Research

    Pancreatic cancer is among the most lethal malignancies worldwide. This study aimed to identify a novel prognostic biomarker, facilitating treatment selection, using mass spectrometry (MS)-based proteomic anal...

    Authors: Tatsuyuki Takadate, Tohru Onogawa, Kiyonaga Fujii, Fuyuhiko Motoi, Sayaka Mikami, Tetsuya Fukuda, Makoto Kihara, Takashi Suzuki, Taro Takemura, Takashi Minowa, Nobutaka Hanagata, Kengo Kinoshita, Takanori Morikawa, Keiichi Shirasaki, Toshiki Rikiyama, Yu Katayose…

    Citation: Clinical Proteomics 2012 9:8

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  27. Content type: Research

    The molecular events that lead to malignant transformation and subsequent metastasis of breast carcinoma include alterations in the cells at genome, transcriptome and proteome levels. In this study, we used pu...

    Authors: Deepthi Telikicherla, Arivusudar Marimuthu, Manoj Kumar Kashyap, Y L Ramachandra, Sujatha Mohan, Juan Carlos Roa, Jagadeesha Maharudraiah and Akhilesh Pandey

    Citation: Clinical Proteomics 2012 9:7

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  28. Content type: Research

    Analysis of key therapeutic targets such as epidermal growth factor receptor (EGFR) in clinical tissue samples is typically done by immunohistochemistry (IHC) and is only subjectively quantitative through a na...

    Authors: Todd Hembrough, Sheeno Thyparambil, Wei-Li Liao, Marlene M Darfler, Joseph Abdo, Kathleen M Bengali, Paul Taylor, Jiefei Tong, Humberto Lara-Guerra, Thomas K Waddell, Michael F Moran, Ming-Sound Tsao, David B Krizman and Jon Burrows

    Citation: Clinical Proteomics 2012 9:5

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  29. Content type: Research

    The diagnosis and management of BK virus (BKV) reactivation following renal transplantation continues to be a significant clinical problem. Following reactivation of latent virus, impaired cellular immunity en...

    Authors: Rebecca Konietzny, Roman Fischer, Nicola Ternette, Cynthia A Wright, Ben W Turney, Aron Chakera, David Hughes, Benedikt M Kessler and Chris W Pugh

    Citation: Clinical Proteomics 2012 9:4

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  30. Content type: Research

    Central nervous system (CNS) infection is a nearly universal feature of untreated systemic HIV infection with a clinical spectrum that ranges from chronic asymptomatic infection to severe cognitive and motor d...

    Authors: Thomas E Angel, Jon M Jacobs, Serena S Spudich, Marina A Gritsenko, Dietmar Fuchs, Teri Liegler, Henrik Zetterberg, David G Camp II, Richard W Price and Richard D Smith

    Citation: Clinical Proteomics 2012 9:3

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  31. Content type: Research

    Prostatitis is an inflammation of the prostate gland which affects approximately 10% of men. Despite its frequency, diagnosing prostatitis and monitoring patient response to treatment remains frustrating. As t...

    Authors: Daniel Kagedan, Irene Lecker, Ihor Batruch, Christopher Smith, Ilia Kaploun, Kirk Lo, Ethan Grober, Eleftherios P Diamandis and Keith A Jarvi

    Citation: Clinical Proteomics 2012 9:2

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  32. Content type: Research

    Biomarkers that improve stratification of colorectal cancer patients for adjuvant therapy versus resection alone, or that are predictive of response to therapeutic agents, have the potential to greatly improve...

    Authors: Georgia Arentz, Tim Chataway, Timothy J Price, Zaipul Izwan, Gemma Hardi, Adrian G Cummins and Jennifer E Hardingham

    Citation: Clinical Proteomics 2011 8:16

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  33. Content type: Research

    The objective of the present study is to identify proteins that change in the extent of the modification with O-linked N-acetylglucosamine (O-GlcNAcylation) in the kidney from diabetic model Goto-Kakizaki (GK) ra...

    Authors: Yoshihiro Akimoto, Yuri Miura, Tosifusa Toda, Margreet A Wolfert, Lance Wells, Geert-Jan Boons, Gerald W Hart, Tamao Endo and Hayato Kawakami

    Citation: Clinical Proteomics 2011 8:15

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  34. Content type: Research

    Raw spectral data from matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) with MS profiling techniques usually contains complex information not readily providing biological insight into dis...

    Authors: Dong L Tong, David J Boocock, Clare Coveney, Jaimy Saif, Susana G Gomez, Sergio Querol, Robert Rees and Graham R Ball

    Citation: Clinical Proteomics 2011 8:14

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  35. Content type: Research

    Early diagnosis of Oral Squamous Cell Carcinoma (OSCC) increases the survival rate of oral cancer. For early diagnosis, molecular biomarkers contained in samples collected non-invasively and directly from at-r...

    Authors: Joel A Kooren, Nelson L Rhodus, Chuanning Tang, Pratik D Jagtap, Bryan J Horrigan and Timothy J Griffin

    Citation: Clinical Proteomics 2011 8:13

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  36. Content type: Research

    To determine whether functional proteomics improves breast cancer classification and prognostication and can predict pathological complete response (pCR) in patients receiving neoadjuvant taxane and anthracycl...

    Authors: Ana M Gonzalez-Angulo, Bryan T Hennessy, Funda Meric-Bernstam, Aysegul Sahin, Wenbin Liu, Zhenlin Ju, Mark S Carey, Simen Myhre, Corey Speers, Lei Deng, Russell Broaddus, Ana Lluch, Sam Aparicio, Powel Brown, Lajos Pusztai, W Fraser Symmans…

    Citation: Clinical Proteomics 2011 8:11

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  37. Content type: Research

    The vast difference in the abundance of different proteins in biological samples limits the determination of the complete proteome of a cell type, requiring fractionation of proteins and peptides before MS ana...

    Authors: Beerelli Seshi, Kumaraguru Raja and KH Chandramouli

    Citation: Clinical Proteomics 2011 8:10

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  38. Content type: Review

    The ADAMs are transmembrane proteins implicated in proteolysis and cell adhesion. Forty gene members of the family have been identified, of which 21 are believed to be functional in humans. As proteases, their...

    Authors: Michael J Duffy, Maeve Mullooly, Norma O'Donovan, Sumainizah Sukor, John Crown, Aisling Pierce and Patricia M McGowan

    Citation: Clinical Proteomics 2011 8:9

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  39. Content type: Review

    Predicting the response to medical therapy and subsequently individualizing the treatment to increase efficacy or reduce toxicity has been a longstanding clinical goal. Not least within oncology, where many pa...

    Authors: Jacob Nersting, Louise Borst and Kjeld Schmiegelow

    Citation: Clinical Proteomics 2011 8:8

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  40. Content type: Research

    In cerebrospinal fluid (CSF), which is a rich source of biomarkers for neurological diseases, identification of biomarkers requires methods that allow reproducible detection of low abundance proteins. It is th...

    Authors: Jacques Borg, Alex Campos, Claudio Diema, Núria Omeñaca, Eliandre de Oliveira, Joan Guinovart and Marta Vilaseca

    Citation: Clinical Proteomics 2011 8:6

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  41. Content type: Research

    Kallikrein-related peptidase 5 (KLK5) is a secreted trypsin-like protease of the KLK family, encoded by the KLK5 gene. KLK5 has been found to cleave various extracellular matrix components, as well as to activate...

    Authors: Margaritis Avgeris, Georgia Papachristopoulou, Athanasios Polychronis and Andreas Scorilas

    Citation: Clinical Proteomics 2011 8:5

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  42. Content type: Research

    Visceral leishmaniasis is a parasitic infection caused by Lesihmania donovani complex and transmitted by the bite of the phlebotomine sand fly. It is an endemic disease in many developing countries with more than...

    Authors: Lokesh A Rukmangadachar, Jitender Kataria, Gururao Hariprasad, Jyotish C Samantaray and Alagiri Srinivasan

    Citation: Clinical Proteomics 2011 8:4

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  43. Content type: Research

    Sulfur mustard "bis (2-chlroethyl) sulphide" (SM) is a chemical warfare agent that remains a threat to human health. The aim of this study was to identify protein expression signature or biomarkers that reflec...

    Authors: Hossein Mehrani, Mostafa Ghanei, Jafar Aslani and Zahra Tabatabaei

    Citation: Clinical Proteomics 2011 8:2

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