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  1. Content type: Research

    Purified protein derivative (PPD) has been used for more than half a century as an antigen for the diagnosis of tuberculosis infection based on delayed type hypersensitivity. Although designated as “purified,”...

    Authors: Thottethodi Subrahmanya Keshava Prasad, Renu Verma, Satish Kumar, Raja Sekhar Nirujogi, Gajanan J Sathe, Anil K Madugundu, Jyoti Sharma, Vinuth N Puttamallesh, Anjali Ganjiwale, Vithal P Myneedu, Aditi Chatterjee, Akhilesh Pandey, HC Harsha and Jayasuryan Narayana

    Citation: Clinical Proteomics 2013 10:8

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  2. Content type: Research

    Heart failure is a multifactorial disease associated with staggeringly high morbidity and motility. Recently, alterations of multiple metabolites have been implicated in heart failure; however, the lack of an ...

    Authors: CY X’avia Chan, Anjum A Khan, JH Howard Choi, CM Dominic Ng, Martin Cadeiras, Mario Deng and Peipei Ping

    Citation: Clinical Proteomics 2013 10:7

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  3. Content type: Research

    Complex molecular events lead to development and progression of liver cirrhosis to HCC. Differentially expressed nuclear membrane associated proteins are responsible for the functional and structural alteratio...

    Authors: Rizma Khan, Saadia Zahid, Yu-Jui Yvonne Wan, Jameson Forster, A-Bashar Abdul Karim, Atta M Nawabi, Abid Azhar, M Ataur Rahman and Nikhat Ahmed

    Citation: Clinical Proteomics 2013 10:6

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  4. Content type: Research

    Alzheimer’s disease (AD) is the most common type of dementia affecting people over 65 years of age. The hallmarks of AD are the extracellular deposits known as amyloid β plaques and the intracellular neurofibr...

    Authors: Ilijana Begcevic, Hari Kosanam, Eduardo Martínez-Morillo, Apostolos Dimitromanolakis, Phedias Diamandis, Uros Kuzmanov, Lili-Naz Hazrati and Eleftherios P Diamandis

    Citation: Clinical Proteomics 2013 10:5

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  5. Content type: Research

    Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with ac...

    Authors: Björg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn and Karin Sundfeldt

    Citation: Clinical Proteomics 2013 10:4

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  6. Content type: Research

    Rabies is a fatal acute viral disease of the central nervous system, which is a serious public health problem in Asian and African countries. Based on the clinical presentation, rabies can be classified into e...

    Authors: Abhilash K Venugopal, S Sameer Kumar Ghantasala, Lakshmi Dhevi N Selvan, Anita Mahadevan, Santosh Renuse, Praveen Kumar, Harsh Pawar, Nandini A Sahasrabhuddhe, Mooriyath S Suja, Yarappa L Ramachandra, Thottethodi S Keshava Prasad, Shampur N Madhusudhana, Harsha HC, Raghothama Chaerkady, Parthasarathy Satishchandra, Akhilesh Pandey…

    Citation: Clinical Proteomics 2013 10:3

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  7. Content type: Research

    Down syndrome (DS), caused by an extra copy of chromosome 21, affects 1 in 750 live births and is characterized by cognitive impairment and a constellation of congenital defects. Currently, little is known abo...

    Authors: Chan-Kyung J Cho, Andrei P Drabovich, George S Karagiannis, Eduardo Martínez-Morillo, Shawn Dason, Apostolos Dimitromanolakis and Eleftherios P Diamandis

    Citation: Clinical Proteomics 2013 10:2

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  8. Content type: Research

    In sickle cell disease (SCD), the mitogen-activated protein kinase (MAPK) ERK1/2 is constitutively active and can be inducible by agonist-stimulation only in sickle but not in normal human red blood cells (RBC...

    Authors: Erik J Soderblom, J Will Thompson, Evan A Schwartz, Edward Chiou, Laura G Dubois, M Arthur Moseley and Rahima Zennadi

    Citation: Clinical Proteomics 2013 10:1

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  9. Content type: Research

    We aimed to investigate the use of ovarian cyst fluid as a source for biomarker discovery and to find novel biomarkers for use in the diagnosis of epithelial ovarian tumors.

    Authors: Björg Kristjansdottir, Karolina Partheen, Eric T Fung, Janusz Marcickiewicz, Christine Yip, Mats Brännström and Karin Sundfeldt

    Citation: Clinical Proteomics 2012 9:14

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  10. Content type: Research

    Autosomal dominant polycystic kidney disease (ADPKD) is responsible for 10% of cases of the end stage renal disease. Early diagnosis, especially of potential fast progressors would be of benefit for efficient ...

    Authors: Magda Bakun, Mariusz Niemczyk, Dominik Domanski, Radek Jazwiec, Anna Perzanowska, Stanislaw Niemczyk, Michal Kistowski, Agnieszka Fabijanska, Agnieszka Borowiec, Leszek Paczek and Michal Dadlez

    Citation: Clinical Proteomics 2012 9:13

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  11. Content type: Research

    Tuberculous meningitis is a frequent extrapulmonary disease caused by Mycobacterium tuberculosis and is associated with high mortality rates and severe neurological sequelae. In an earlier study employing DNA mic...

    Authors: Ghantasala S Sameer Kumar, Abhilash K Venugopal, Anita Mahadevan, Santosh Renuse, H C Harsha, Nandini A Sahasrabuddhe, Harsh Pawar, Rakesh Sharma, Praveen Kumar, Sudha Rajagopalan, Keith Waddell, Yarappa L Ramachandra, Parthasarathy Satishchandra, Raghothama Chaerkady, T S Keshava Prasad, K Shankar…

    Citation: Clinical Proteomics 2012 9:12

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  12. Content type: Research

    Pathogenesis of liver damage in patients with HIV and HCV co-infection is complex and multifactorial. Although global awareness regarding HIV-1/HCV co-infection is increasing little is known about the pathophy...

    Authors: Nawal M Boukli, Vivekananda Shetty, Luis Cubano, Martha Ricaurte, Jordana Coelho-dos-Reis, Zacharie Nickens, Punit Shah, Andrew H Talal, Ramila Philip and Pooja Jain

    Citation: Clinical Proteomics 2012 9:11

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  13. Content type: Research

    In approximately 80% of patients, ovarian cancer is diagnosed when the patient is already in the advanced stages of the disease. CA125 is currently used as the marker for ovarian cancer; however, it lacks spec...

    Authors: Vivekananda Shetty, Julie Hafner, Punit Shah, Zacharie Nickens and Ramila Philip

    Citation: Clinical Proteomics 2012 9:10

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  14. Content type: Research

    Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS). It involves damage to the myelin sheath surrounding axons and to the axons themselves. MS most often presents with a...

    Authors: Yan Jia, Tianxia Wu, Christine A Jelinek, Bibiana Bielekova, Linda Chang, Scott Newsome, Sharmilee Gnanapavan, Gavin Giovannoni, Dawn Chen, Peter A Calabresi, Avindra Nath and Robert J Cotter

    Citation: Clinical Proteomics 2012 9:9

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  15. Content type: Meeting report

    A National Institutes of Health (NIH) workshop was convened in Bethesda, MD on September 26–27, 2011, with representative scientific leaders in the field of proteomics and its applications to clinical settings...

    Authors: Marc Vidal, Daniel W Chan, Mark Gerstein, Matthias Mann, Gilbert S Omenn, Danilo Tagle and Salvatore Sechi

    Citation: Clinical Proteomics 2012 9:6

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  16. Content type: Research

    Pancreatic cancer is among the most lethal malignancies worldwide. This study aimed to identify a novel prognostic biomarker, facilitating treatment selection, using mass spectrometry (MS)-based proteomic anal...

    Authors: Tatsuyuki Takadate, Tohru Onogawa, Kiyonaga Fujii, Fuyuhiko Motoi, Sayaka Mikami, Tetsuya Fukuda, Makoto Kihara, Takashi Suzuki, Taro Takemura, Takashi Minowa, Nobutaka Hanagata, Kengo Kinoshita, Takanori Morikawa, Keiichi Shirasaki, Toshiki Rikiyama, Yu Katayose…

    Citation: Clinical Proteomics 2012 9:8

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  17. Content type: Research

    The molecular events that lead to malignant transformation and subsequent metastasis of breast carcinoma include alterations in the cells at genome, transcriptome and proteome levels. In this study, we used pu...

    Authors: Deepthi Telikicherla, Arivusudar Marimuthu, Manoj Kumar Kashyap, Y L Ramachandra, Sujatha Mohan, Juan Carlos Roa, Jagadeesha Maharudraiah and Akhilesh Pandey

    Citation: Clinical Proteomics 2012 9:7

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  18. Content type: Research

    Analysis of key therapeutic targets such as epidermal growth factor receptor (EGFR) in clinical tissue samples is typically done by immunohistochemistry (IHC) and is only subjectively quantitative through a na...

    Authors: Todd Hembrough, Sheeno Thyparambil, Wei-Li Liao, Marlene M Darfler, Joseph Abdo, Kathleen M Bengali, Paul Taylor, Jiefei Tong, Humberto Lara-Guerra, Thomas K Waddell, Michael F Moran, Ming-Sound Tsao, David B Krizman and Jon Burrows

    Citation: Clinical Proteomics 2012 9:5

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  19. Content type: Research

    The diagnosis and management of BK virus (BKV) reactivation following renal transplantation continues to be a significant clinical problem. Following reactivation of latent virus, impaired cellular immunity en...

    Authors: Rebecca Konietzny, Roman Fischer, Nicola Ternette, Cynthia A Wright, Ben W Turney, Aron Chakera, David Hughes, Benedikt M Kessler and Chris W Pugh

    Citation: Clinical Proteomics 2012 9:4

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  20. Content type: Research

    Central nervous system (CNS) infection is a nearly universal feature of untreated systemic HIV infection with a clinical spectrum that ranges from chronic asymptomatic infection to severe cognitive and motor d...

    Authors: Thomas E Angel, Jon M Jacobs, Serena S Spudich, Marina A Gritsenko, Dietmar Fuchs, Teri Liegler, Henrik Zetterberg, David G Camp II, Richard W Price and Richard D Smith

    Citation: Clinical Proteomics 2012 9:3

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  21. Content type: Research

    Prostatitis is an inflammation of the prostate gland which affects approximately 10% of men. Despite its frequency, diagnosing prostatitis and monitoring patient response to treatment remains frustrating. As t...

    Authors: Daniel Kagedan, Irene Lecker, Ihor Batruch, Christopher Smith, Ilia Kaploun, Kirk Lo, Ethan Grober, Eleftherios P Diamandis and Keith A Jarvi

    Citation: Clinical Proteomics 2012 9:2

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  22. Content type: Research

    Biomarkers that improve stratification of colorectal cancer patients for adjuvant therapy versus resection alone, or that are predictive of response to therapeutic agents, have the potential to greatly improve...

    Authors: Georgia Arentz, Tim Chataway, Timothy J Price, Zaipul Izwan, Gemma Hardi, Adrian G Cummins and Jennifer E Hardingham

    Citation: Clinical Proteomics 2011 8:16

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  23. Content type: Research

    The objective of the present study is to identify proteins that change in the extent of the modification with O-linked N-acetylglucosamine (O-GlcNAcylation) in the kidney from diabetic model Goto-Kakizaki (GK) ra...

    Authors: Yoshihiro Akimoto, Yuri Miura, Tosifusa Toda, Margreet A Wolfert, Lance Wells, Geert-Jan Boons, Gerald W Hart, Tamao Endo and Hayato Kawakami

    Citation: Clinical Proteomics 2011 8:15

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  24. Content type: Research

    Raw spectral data from matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) with MS profiling techniques usually contains complex information not readily providing biological insight into dis...

    Authors: Dong L Tong, David J Boocock, Clare Coveney, Jaimy Saif, Susana G Gomez, Sergio Querol, Robert Rees and Graham R Ball

    Citation: Clinical Proteomics 2011 8:14

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  25. Content type: Research

    Early diagnosis of Oral Squamous Cell Carcinoma (OSCC) increases the survival rate of oral cancer. For early diagnosis, molecular biomarkers contained in samples collected non-invasively and directly from at-r...

    Authors: Joel A Kooren, Nelson L Rhodus, Chuanning Tang, Pratik D Jagtap, Bryan J Horrigan and Timothy J Griffin

    Citation: Clinical Proteomics 2011 8:13

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  26. Content type: Research

    To determine whether functional proteomics improves breast cancer classification and prognostication and can predict pathological complete response (pCR) in patients receiving neoadjuvant taxane and anthracycl...

    Authors: Ana M Gonzalez-Angulo, Bryan T Hennessy, Funda Meric-Bernstam, Aysegul Sahin, Wenbin Liu, Zhenlin Ju, Mark S Carey, Simen Myhre, Corey Speers, Lei Deng, Russell Broaddus, Ana Lluch, Sam Aparicio, Powel Brown, Lajos Pusztai, W Fraser Symmans…

    Citation: Clinical Proteomics 2011 8:11

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  27. Content type: Research

    The vast difference in the abundance of different proteins in biological samples limits the determination of the complete proteome of a cell type, requiring fractionation of proteins and peptides before MS ana...

    Authors: Beerelli Seshi, Kumaraguru Raja and KH Chandramouli

    Citation: Clinical Proteomics 2011 8:10

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  28. Content type: Review

    The ADAMs are transmembrane proteins implicated in proteolysis and cell adhesion. Forty gene members of the family have been identified, of which 21 are believed to be functional in humans. As proteases, their...

    Authors: Michael J Duffy, Maeve Mullooly, Norma O'Donovan, Sumainizah Sukor, John Crown, Aisling Pierce and Patricia M McGowan

    Citation: Clinical Proteomics 2011 8:9

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  29. Content type: Review

    Predicting the response to medical therapy and subsequently individualizing the treatment to increase efficacy or reduce toxicity has been a longstanding clinical goal. Not least within oncology, where many pa...

    Authors: Jacob Nersting, Louise Borst and Kjeld Schmiegelow

    Citation: Clinical Proteomics 2011 8:8

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  30. Content type: Research

    In cerebrospinal fluid (CSF), which is a rich source of biomarkers for neurological diseases, identification of biomarkers requires methods that allow reproducible detection of low abundance proteins. It is th...

    Authors: Jacques Borg, Alex Campos, Claudio Diema, Núria Omeñaca, Eliandre de Oliveira, Joan Guinovart and Marta Vilaseca

    Citation: Clinical Proteomics 2011 8:6

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  31. Content type: Research

    Kallikrein-related peptidase 5 (KLK5) is a secreted trypsin-like protease of the KLK family, encoded by the KLK5 gene. KLK5 has been found to cleave various extracellular matrix components, as well as to activate...

    Authors: Margaritis Avgeris, Georgia Papachristopoulou, Athanasios Polychronis and Andreas Scorilas

    Citation: Clinical Proteomics 2011 8:5

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  32. Content type: Research

    Visceral leishmaniasis is a parasitic infection caused by Lesihmania donovani complex and transmitted by the bite of the phlebotomine sand fly. It is an endemic disease in many developing countries with more than...

    Authors: Lokesh A Rukmangadachar, Jitender Kataria, Gururao Hariprasad, Jyotish C Samantaray and Alagiri Srinivasan

    Citation: Clinical Proteomics 2011 8:4

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  33. Content type: Research

    Sulfur mustard "bis (2-chlroethyl) sulphide" (SM) is a chemical warfare agent that remains a threat to human health. The aim of this study was to identify protein expression signature or biomarkers that reflec...

    Authors: Hossein Mehrani, Mostafa Ghanei, Jafar Aslani and Zahra Tabatabaei

    Citation: Clinical Proteomics 2011 8:2

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  34. Content type: Research

    Experiments show that upon traumatic injury the composition of mesenteric lymph changes such that it initiates an immune response that can ultimately result in multiple organ dysfunction syndrome (MODS). To id...

    Authors: Ashley Zurawel, Ernest E Moore, Erik D Peltz, Janeen R Jordan, Sagar Damle, Monika Dzieciatkowska, Anirban Banerjee and Kirk C Hansen

    Citation: Clinical Proteomics 2010 8:1

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  35. Content type: Article

    The lack of large panels of validated antibodies, tissue handling variability, and intratumoral heterogeneity potentially hamper comprehensive study of the functional proteome in non-microdissected solid tumor...

    Authors: Bryan T. Hennessy, Yiling Lu, Ana Maria Gonzalez-Angulo, Mark S. Carey, Simen Myhre, Zhenlin Ju, Michael A. Davies, Wenbin Liu, Kevin Coombes, Funda Meric-Bernstam, Isabelle Bedrosian, Mollianne McGahren, Roshan Agarwal, Fan Zhang, Jens Overgaard, Jan Alsner…

    Citation: Clinical Proteomics 2010 6:9055

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  36. Content type: Article

    Proteomic characterization of the human pancreatic islets, containing the insulin producing beta-cells, is likely to be of great importance for improved treatment and understanding of the pathophysiology of di...

    Authors: Sara F. Hansson, Åsa Henriksson, Lars Johansson, Olle Korsgren, Jan W. Eriksson, Hans Tornqvist and Pia Davidsson

    Citation: Clinical Proteomics 2010 6:9060

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  37. Content type: Article

    Candida albicans and Candida glabrata are the two most common opportunistic pathogens which are part of the normal flora in humans. Clinical diagnosis of infection by these organisms is still largely based on cul...

    Authors: Thottethodi Subrahmanya Keshava Prasad, Shivakumar Keerthikumar, Raghothama Chaerkady, Kumaran Kandasamy, Santosh Renuse, Arivusudar Marimuthu, Abhilash Karavattu Venugopal, Joji Kurian Thomas, Harrys K. C. Jacob, Renu Goel, Harsh Pawar, Nandini A. Sahasrabuddhe, Venkatarangaiah Krishna, Bipin G. Nair, Marjan Gucek, Robert N. Cole…

    Citation: Clinical Proteomics 2010 6:9057

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  38. Content type: Article

    Systemic juvenile idiopathic arthritis is a chronic pediatric disease. The initial clinical presentation can mimic other pediatric inflammatory conditions, which often leads to significant delays in diagnosis ...

    Authors: Xuefeng B. Ling, Kenneth Lau, Chetan Deshpande, Jane L. Park, Diana Milojevic, Claudia Macaubas, Chris Xiao, Viorica Lopez-Avila, John Kanegaye, Jane C. Burns, Harvey Cohen, James Schilling and Elizabeth D. Mellins

    Citation: Clinical Proteomics 2010 6:9058

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  39. Content type: Article

    In the search for novel cancer biomarkers, various proteolytically derived peptides have been proposed to exhibit cancer or cancer-type specificity. As these peptides are presumably also generated after sample...

    Authors: Irene van den Broek, Rolf W. Sparidans, Jan H. M. Schellens and Jos H. Beijnen

    Citation: Clinical Proteomics 2010 6:9054

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  40. Content type: Article

    High glucose concentrations induce the production of IL-1β in human pancreatic beta cells leading to impaired insulin secretion, decreased cell proliferation and apoptosis. Blockade of IL-1 signalling with the...

    Authors: Mette Koefoed, Claus M. Larsen, Mirjam V. Faulenbach, Allan Vaag, Jan A. Ehses, Marc Y. Donath, James Norton McGuire, Flemming Pociot and Thomas Mandrup-Poulsen

    Citation: Clinical Proteomics 2010 6:9056

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  41. Content type: Article

    As part of a clinical proteomics programme focused on diabetes and its complications, it was our goal to investigate the proteome of plasma in order to find improved candidate biomarkers to predict diabetic ne...

    Authors: Anne Julie Overgaard, Tine E. Thingholm, Martin R. Larsen, Lise Tarnow, Peter Rossing, James N. McGuire and Flemming Pociot

    Citation: Clinical Proteomics 2010 6:9053

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  42. Content type: Article

    Radiographic contrast media (RCM) have numerous effects on the hemostatic system, inflammatory pathways, and vascular endothelium. Given the increasing number of high-risk patients undergoing radiographic proc...

    Authors: Juan Martinez, Warren K. Laskey, Cheri Wells, Armin Foghi, Sarah Rohde, Mark Ricciardi and Charlotte Mobarak

    Citation: Clinical Proteomics 2010 6:9048

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  43. Content type: Article

    The objective of this study was to identify cancer-associated protein expression patterns in bilateral matched nipple aspiration fluids using nanoscale reciprocal Cy3/Cy5 labeling and high-content antibody mic...

    Authors: Jinong Li, Junma Zhou, Bruce Trock, Theodore N. Tsangaris, Neil B. Friedman, Deanna Shapiro, Michelle Brotzman and Daniel W. Chan

    Citation: Clinical Proteomics 2010 6:9046

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