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  1. CT screening for lung cancer is effective in reducing mortality, but there are areas of concern, including a positive predictive value of 4% and development of interval cancers. A blood test that could manage ...

    Authors: Michael R Mehan, Stephen A Williams, Jill M Siegfried, William L Bigbee, Joel L Weissfeld, David O Wilson, Harvey I Pass, William N Rom, Thomas Muley, Michael Meister, Wilbur Franklin, York E Miller, Edward N Brody and Rachel M Ostroff

    Citation: Clinical Proteomics 2014 11:32

    Content type: Research

    Published on:

  2. The proteomic analysis of body fluids is a growing technology for the identification of protein biomarkers of disease. Given that Papanicolaou tests (Pap tests) are routinely performed on over 30 million women...

    Authors: Kristin LM Boylan, Somaieh Afiuni-Zadeh, Melissa A Geller, Kayla Hickey, Timothy J Griffin, Stefan E Pambuccian and Amy PN Skubitz

    Citation: Clinical Proteomics 2014 11:30

    Content type: Research

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  3. The vitreous humor is a transparent, gelatinous mass whose main constituent is water. It plays an important role in providing metabolic nutrient requirements of the lens, coordinating eye growth and providing ...

    Authors: Krishna R Murthy, Renu Goel, Yashwanth Subbannayya, Harrys KC Jacob, Praveen R Murthy, Srikanth Srinivas Manda, Arun H Patil, Rakesh Sharma, Nandini A Sahasrabuddhe, Arun Parashar, Bipin G Nair, Venkatarangaiah Krishna, TS Keshava Prasad, Harsha Gowda and Akhilesh Pandey

    Citation: Clinical Proteomics 2014 11:29

    Content type: Research

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  4. The growing field of formalin-fixed paraffin-embedded (FFPE) tissue proteomics holds promise for improving translational research. Direct tissue trypsinization (DT) and protein extraction followed by in soluti...

    Authors: Alessandro Tanca, Marcello Abbondio, Salvatore Pisanu, Daniela Pagnozzi, Sergio Uzzau and Maria Filippa Addis

    Citation: Clinical Proteomics 2014 11:28

    Content type: Research

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  5. Synovial fluid (SF) is a dynamic reservoir for proteins originating from the synovial membrane, cartilage, and plasma, and may therefore reflect the pathophysiological conditions that give rise to arthritis. O...

    Authors: Daniela Cretu, Ioannis Prassas, Punit Saraon, Ihor Batruch, Rajiv Gandhi, Eleftherios P Diamandis and Vinod Chandran

    Citation: Clinical Proteomics 2014 11:27

    Content type: Research

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  6. Dysregulation of glycoproteins is closely related with many diseases. Quantitative proteomics methods are powerful tools for the detection of glycoprotein alterations. However, in almost all quantitative glyco...

    Authors: Zhen Sun, Deguang Sun, Fangjun Wang, Kai Cheng, Zhang Zhang, Bo Xu, Mingliang Ye, Liming Wang and Hanfa Zou

    Citation: Clinical Proteomics 2014 11:26

    Content type: Research

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  7. Glycoproteins comprise a large portion of the salivary proteome and have great potential for biomarker discovery and disease diagnosis. However, the rate of production and the concentration of whole saliva cha...

    Authors: Shisheng Sun, Fei Zhao, Qinzhe Wang, Yaogang Zhong, Tanxi Cai, Peng Wu, Fuquan Yang and Zheng Li

    Citation: Clinical Proteomics 2014 11:25

    Content type: Research

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  8. Histone post-translational modifications (PTMs) play an important role in the regulation of the expression of genes, including those involved in cancer development and progression. However, our knowledge of PT...

    Authors: Jakub Karczmarski, Tymon Rubel, Agnieszka Paziewska, Michal Mikula, Mateusz Bujko, Paulina Kober, Michal Dadlez and Jerzy Ostrowski

    Citation: Clinical Proteomics 2014 11:24

    Content type: Research

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  9. Ovarian cancer (OvCa) is the most lethal gynecological malignancy. The emergence of high-throughput technologies, such as mass spectrometry, has allowed for a paradigm shift in the way we search for novel biom...

    Authors: Christopher R Smith, Ihor Batruch, Josep Miquel Bauça, Hari Kosanam, Julia Ridley, Marcus Q Bernardini, Felix Leung, Eleftherios P Diamandis and Vathany Kulasingam

    Citation: Clinical Proteomics 2014 11:23

    Content type: Research

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  11. Protein glycosylation, as an important post-translational modification, is implicated in a number of ailments. Applying proteomic approaches, including mass spectrometry (MS) analyses that have played a signif...

    Authors: Hu Zhao, Yaojun Li and Ye Hu

    Citation: Clinical Proteomics 2014 11:21

    Content type: Review

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  12. Adipose tissue is both an energy storage depot and an endocrine organ. The impaired regulation of the secreted proteins of adipose tissue, known as adipocytokines, observed during obesity contributes to the on...

    Authors: Jae-Min Lim, Edith E Wollaston-Hayden, Chin Fen Teo, Dorothy Hausman and Lance Wells

    Citation: Clinical Proteomics 2014 11:20

    Content type: Research

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  13. Estrogen has been shown to mediate protection in female hearts against ischemia-reperfusion (I-R) stress. Composed by a Kir6.2 pore and an SUR2 regulatory subunit, cardiac ATP-sensitive potassium channels (KAT...

    Authors: Jianjiong Gao, Dong Xu, Grzegorz Sabat, Hector Valdivia, Wei Xu and Nian-Qing Shi

    Citation: Clinical Proteomics 2014 11:19

    Content type: Research

    Published on:

  15. Peritoneal dialysis (PD) is a form of renal replacement used for advanced chronic kidney disease. PD effluent holds a great potential for biomarker discovery for diagnosis and prognosis. In this study a novel ...

    Authors: Elisabete Oliveira, José E Araújo, Silvana Gómez-Meire, Carlos Lodeiro, Cristina Perez-Melon, Elena Iglesias-Lamas, Alfonso Otero-Glez, José L Capelo and Hugo M Santos

    Citation: Clinical Proteomics 2014 11:17

    Content type: Research

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  16. Gel- based proteomics is one of the most versatile methods for fractionating protein complexes. Among these methods, two dimensional- polyacrylamide gel electrophoresis (2-DE) represents a mainstay orthogonal ...

    Authors: Sameh Magdeldin, Shymaa Enany, Yutaka Yoshida, Bo Xu, Ying Zhang, Zam Zureena, Ilambarthi Lokamani, Eishin Yaoita and Tadashi Yamamoto

    Citation: Clinical Proteomics 2014 11:16

    Content type: Review

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  17. Protein glycosylation serves critical roles in the cellular and biological processes of many organisms. Aberrant glycosylation has been associated with many illnesses such as hereditary and chronic diseases li...

    Authors: Deniz Baycin Hizal, Daniel Wolozny, Joseph Colao, Elena Jacobson, Yuan Tian, Sharon S Krag, Michael J Betenbaugh and Hui Zhang

    Citation: Clinical Proteomics 2014 11:15

    Content type: Review

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  18. Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associate...

    Authors: Huan Liu, Ningbo Zhang, Debin Wan, Meng Cui, Zhiqiang Liu and Shuying Liu

    Citation: Clinical Proteomics 2014 11:14

    Content type: Review

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  19. Conventional proteomic approaches have thus far been unable to identify novel serum biomarkers for ovarian cancer that are more sensitive and specific than the current clinically used marker, CA-125. Because e...

    Authors: Anand Bery, Felix Leung, Christopher R Smith, Eleftherios P Diamandis and Vathany Kulasingam

    Citation: Clinical Proteomics 2014 11:13

    Content type: Research

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  20. Transthyretin (TTR), an abundant protein in cerebrospinal fluid (CSF), contains a free, oxidation-prone cysteine residue that gives rise to TTR isoforms. These isoforms may reflect conditions in vivo. Since incre...

    Authors: Keld Poulsen, Justyna MC Bahl, Anja H Simonsen, Steen G Hasselbalch and Niels HH Heegaard

    Citation: Clinical Proteomics 2014 11:12

    Content type: Research

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  22. It is well known that cell surface glycans or glycocalyx play important roles in sperm motility, maturation and fertilization. A comprehensive profile of the sperm surface glycans will greatly facilitate both ...

    Authors: Ai-Jie Xin, Li Cheng, Hua Diao, Peng Wang, Yi-Hua Gu, Bin Wu, Yan-Cheng Wu, Guo-Wu Chen, Shu-Min Zhou, Shu-Juan Guo, Hui-Juan Shi and Sheng-Ce Tao

    Citation: Clinical Proteomics 2014 11:10

    Content type: Research

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  23. Glycoproteins secreted into plasma from T cells infected with human immunodeficiency virus (HIV) latent infection may provide insight into understanding the host response to HIV infection in vivo. Glycoproteomics...

    Authors: Weiming Yang, Jian-Ying Zhou, Li Chen, Minghui Ao, Shisheng Sun, Paul Aiyetan, Antoine Simmons, Hui Zhang and Jay Brooks Jackson

    Citation: Clinical Proteomics 2014 11:9

    Content type: Research

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  24. O-linked β-D-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) onto serine and threonine residues of proteins is an important post-translational modification (PTM), which is involved in many crucial b...

    Authors: Junfeng Ma and Gerald W Hart

    Citation: Clinical Proteomics 2014 11:8

    Content type: Review

    Published on:

  25. Analysis of native or endogenous peptides in biofluids can provide valuable insights into disease mechanisms. Furthermore, the detected peptides may also have utility as potential biomarkers for non-invasive m...

    Authors: Tara K Sigdel, Carrie D Nicora, Szu-Chuan Hsieh, Hong Dai, Wei-Jun Qian, David G Camp II and Minnie M Sarwal

    Citation: Clinical Proteomics 2014 11:7

    Content type: Research

    Published on:

  26. Osteoarthritis is a chronic musculoskeletal disorder characterized mainly by progressive degradation of the hyaline cartilage. Patients with osteoarthritis often postpone seeking medical help, which results in...

    Authors: Lavanya Balakrishnan, Raja Sekhar Nirujogi, Sartaj Ahmad, Mitali Bhattacharjee, Srikanth S Manda, Santosh Renuse, Dhanashree S Kelkar, Yashwanth Subbannayya, Rajesh Raju, Renu Goel, Joji Kurian Thomas, Navjyot Kaur, Mukesh Dhillon, Shantal Gupta Tankala, Ramesh Jois, Vivek Vasdev…

    Citation: Clinical Proteomics 2014 11:6

    Content type: Research

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  27. Cryptococcus neoformans, a basidiomycetous fungus of universal occurrence, is a significant opportunistic human pathogen causing meningitis. Owing to an increase in the number of immunosuppressed individuals alon...

    Authors: Lakshmi Dhevi Nagarajha Selvan, Jyothi Embekkat Kaviyil, Raja Sekhar Nirujogi, Babylakshmi Muthusamy, Vinuth N Puttamallesh, Tejaswini Subbannayya, Nazia Syed, Aneesha Radhakrishnan, Dhanashree S Kelkar, Sartaj Ahmad, Sneha M Pinto, Praveen Kumar, Anil K Madugundu, Bipin Nair, Aditi Chatterjee, Akhilesh Pandey…

    Citation: Clinical Proteomics 2014 11:5

    Content type: Research

    Published on:

  28. Numerous formaldehyde-fixed and paraffin-embedded clinical tissues have been created in the past decades and stored in pathological depositories at hospitals as well as in clinical laboratories worldwide. In a...

    Authors: Yusuke Kawashima, Yoshio Kodera, Anil Singh, Masaomi Matsumoto and Hiroyuki Matsumoto

    Citation: Clinical Proteomics 2014 11:4

    Content type: Research

    Published on:

  29. Protein biomarkers offer major benefits for diagnosis and monitoring of disease processes. Recent advances in protein mass spectrometry make it feasible to use this very sensitive technology to detect and quan...

    Authors: John Marshall, Peter Bowden, Jean Claude Schmit and Fay Betsou

    Citation: Clinical Proteomics 2014 11:3

    Content type: Research

    Published on:

  30. Experts agree that one of the more promising strategies in cancer management is early detection coupled with early intervention. In this study, we evaluated an early cancer detection strategy of cancer presenc...

    Authors: Claudia Hanau, D James Morré and Dorothy M Morré

    Citation: Clinical Proteomics 2014 11:2

    Content type: Research

    Published on:

  31. Rheumatoid arthritis and osteoarthritis are two common musculoskeletal disorders that affect the joints. Despite high prevalence rates, etiological factors involved in these disorders remain largely unknown. D...

    Authors: Lavanya Balakrishnan, Mitali Bhattacharjee, Sartaj Ahmad, Raja Sekhar Nirujogi, Santosh Renuse, Yashwanth Subbannayya, Arivusudar Marimuthu, Srinivas M Srikanth, Rajesh Raju, Mukesh Dhillon, Navjyot Kaur, Ramesh Jois, Vivek Vasudev, YL Ramachandra, Nandini A Sahasrabuddhe, TS Keshava Prasad…

    Citation: Clinical Proteomics 2014 11:1

    Content type: Research

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  32. Plasma renin activity (PRA) is an essential analytical tool for screening and diagnosis of secondary forms of hypertension. Typically, PRA is measured by competitive radioimmunoassay, but there are significant...

    Authors: Alexander G Camenzind, Jessica Grace van der Gugten, Robert Popp, Daniel T Holmes and Christoph H Borchers

    Citation: Clinical Proteomics 2013 10:20

    Content type: Research

    Published on:

  33. Potential biomarkers to aid diagnosis and therapy need to be identified for Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The present study was designed to identify the fac...

    Authors: Anu Mary Varghese, Aparna Sharma, Poojashree Mishra, Kalyan Vijayalakshmi, Hindalahalli Chandregowda Harsha, Talakad N Sathyaprabha, Srinivas MM Bharath, Atchayaram Nalini, Phalguni Anand Alladi and Trichur R Raju

    Citation: Clinical Proteomics 2013 10:19

    Content type: Research

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  34. The rapid advancement of high-throughput tools for quantitative measurement of proteins has demonstrated the potential for the identification of proteins associated with cancer. However, the quantitative resul...

    Authors: Jing Chen, Shadi Toghi Eshghi, George Steven Bova, Qing Kay Li, Xingde Li and Hui Zhang

    Citation: Clinical Proteomics 2013 10:18

    Content type: Research

    Published on:

  35. Serine hydrolases constitute a large enzyme family involved in a diversity of proteolytic and metabolic processes which are essential for many aspects of normal physiology. The roles of serine hydrolases in re...

    Authors: Mario Navarrete, Julie Ho, Oleg Krokhin, Peyman Ezzati, Claudio Rigatto, Martina Reslerova, David N Rush, Peter Nickerson and John A Wilkins

    Citation: Clinical Proteomics 2013 10:17

    Content type: Research

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  36. Serum biomarkers can improve diagnosis and treatment of malignant pleural mesothelioma (MPM). However, the evaluation of potential new serum biomarker candidates is hampered by a lack of assay technologies for...

    Authors: Ferdinando Cerciello, Meena Choi, Annalisa Nicastri, Damaris Bausch-Fluck, Annemarie Ziegler, Olga Vitek, Emanuela Felley-Bosco, Rolf Stahel, Ruedi Aebersold and Bernd Wollscheid

    Citation: Clinical Proteomics 2013 10:16

    Content type: Research

    Published on:

  37. Lung cancer is the number one cause of cancer-related deaths in the United States and worldwide. The complex protein changes and/or signature of protein expression in lung cancer, particularly in non-small cel...

    Authors: Yan Li, Xiangchun Wang, MingHui Ao, Edward Gabrielson, Frederic Askin, Hui Zhang and Qing Kay Li

    Citation: Clinical Proteomics 2013 10:15

    Content type: Research

    Published on:

  38. Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-stranded RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis and host...

    Authors: Vinuth N Puttamallesh, Sreelakshmi K Sreenivasamurthy, Pradeep Kumar Singh, H C Harsha, Anjali Ganjiwale, Shobha Broor, Akhilesh Pandey, Jayasuryan Narayana and T S Keshava Prasad

    Citation: Clinical Proteomics 2013 10:14

    Content type: Research

    Published on:

  41. Arthritis refers to inflammation of joints and includes common disorders such as rheumatoid arthritis (RA) and spondyloarthropathies (SpAs). These diseases differ mainly in terms of their clinical manifestatio...

    Authors: Mitali Bhattacharjee, Rakesh Sharma, Renu Goel, Lavanya Balakrishnan, Santosh Renuse, Jayshree Advani, Shantal Tankala Gupta, Renu Verma, Sneha M Pinto, Nirujogi Raja Sekhar, Bipin Nair, T S Keshava Prasad, H C Harsha, Ramesh Jois, Subramanian Shankar and Akhilesh Pandey

    Citation: Clinical Proteomics 2013 10:11

    Content type: Research

    Published on:

  42. To characterize changes in global protein expression in kidneys of transgenic rats overexpressing human selenoprotein M (SelM) in response to increased bioabivility of selenium (Sel), total proteins extracted ...

    Authors: Jun Seo Goo, Yo Na Kim, Kyung Mi Choi, In Sik Hwang, Ji Eun Kim, Young Ju Lee, Moon Hwa Kwak, Sun Bo Shim, Seung Wan Jee, Chul Joo Lim, Je Kyung Seong and Dae Youn Hwang

    Citation: Clinical Proteomics 2013 10:10

    Content type: Research

    Published on:

  43. The ciliary body is the circumferential muscular tissue located just behind the iris in the anterior chamber of the eye. It plays a pivotal role in the production of aqueous humor, maintenance of the lens zonu...

    Authors: Renu Goel, Krishna R Murthy, Srinivas M Srikanth, Sneha M Pinto, Mitali Bhattacharjee, Dhanashree S Kelkar, Anil K Madugundu, Gourav Dey, Sujatha S Mohan, Venkatarangaiah Krishna, TS Keshava Prasad, Shukti Chakravarti, HC Harsha and Akhilesh Pandey

    Citation: Clinical Proteomics 2013 10:9

    Content type: Research

    Published on:

  44. Purified protein derivative (PPD) has been used for more than half a century as an antigen for the diagnosis of tuberculosis infection based on delayed type hypersensitivity. Although designated as “purified,”...

    Authors: Thottethodi Subrahmanya Keshava Prasad, Renu Verma, Satish Kumar, Raja Sekhar Nirujogi, Gajanan J Sathe, Anil K Madugundu, Jyoti Sharma, Vinuth N Puttamallesh, Anjali Ganjiwale, Vithal P Myneedu, Aditi Chatterjee, Akhilesh Pandey, HC Harsha and Jayasuryan Narayana

    Citation: Clinical Proteomics 2013 10:8

    Content type: Research

    Published on:

  45. Heart failure is a multifactorial disease associated with staggeringly high morbidity and motility. Recently, alterations of multiple metabolites have been implicated in heart failure; however, the lack of an ...

    Authors: CY X’avia Chan, Anjum A Khan, JH Howard Choi, CM Dominic Ng, Martin Cadeiras, Mario Deng and Peipei Ping

    Citation: Clinical Proteomics 2013 10:7

    Content type: Research

    Published on:

  46. Complex molecular events lead to development and progression of liver cirrhosis to HCC. Differentially expressed nuclear membrane associated proteins are responsible for the functional and structural alteratio...

    Authors: Rizma Khan, Saadia Zahid, Yu-Jui Yvonne Wan, Jameson Forster, A-Bashar Abdul Karim, Atta M Nawabi, Abid Azhar, M Ataur Rahman and Nikhat Ahmed

    Citation: Clinical Proteomics 2013 10:6

    Content type: Research

    Published on:

  47. Alzheimer’s disease (AD) is the most common type of dementia affecting people over 65 years of age. The hallmarks of AD are the extracellular deposits known as amyloid β plaques and the intracellular neurofibr...

    Authors: Ilijana Begcevic, Hari Kosanam, Eduardo Martínez-Morillo, Apostolos Dimitromanolakis, Phedias Diamandis, Uros Kuzmanov, Lili-Naz Hazrati and Eleftherios P Diamandis

    Citation: Clinical Proteomics 2013 10:5

    Content type: Research

    Published on:

  48. Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with ac...

    Authors: Björg Kristjansdottir, Kristina Levan, Karolina Partheen, Elisabet Carlsohn and Karin Sundfeldt

    Citation: Clinical Proteomics 2013 10:4

    Content type: Research

    Published on:

  49. Rabies is a fatal acute viral disease of the central nervous system, which is a serious public health problem in Asian and African countries. Based on the clinical presentation, rabies can be classified into e...

    Authors: Abhilash K Venugopal, S Sameer Kumar Ghantasala, Lakshmi Dhevi N Selvan, Anita Mahadevan, Santosh Renuse, Praveen Kumar, Harsh Pawar, Nandini A Sahasrabhuddhe, Mooriyath S Suja, Yarappa L Ramachandra, Thottethodi S Keshava Prasad, Shampur N Madhusudhana, Harsha HC, Raghothama Chaerkady, Parthasarathy Satishchandra, Akhilesh Pandey…

    Citation: Clinical Proteomics 2013 10:3

    Content type: Research

    Published on:

  50. Down syndrome (DS), caused by an extra copy of chromosome 21, affects 1 in 750 live births and is characterized by cognitive impairment and a constellation of congenital defects. Currently, little is known abo...

    Authors: Chan-Kyung J Cho, Andrei P Drabovich, George S Karagiannis, Eduardo Martínez-Morillo, Shawn Dason, Apostolos Dimitromanolakis and Eleftherios P Diamandis

    Citation: Clinical Proteomics 2013 10:2

    Content type: Research

    Published on:

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Clinical Proteomics

ISSN: 1559-0275