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  1. The anatomy of PFO suggests that it can allow thrombi and potentially harmful circulatory factors to travel directly from the venous to the arterial circulation – altering circulatory phenotype. Our previous p...

    Authors: Mary F Lopez, Bryan Krastins, David A Sarracino, Gregory Byram, Maryann S Vogelsang, Amol Prakash, Scott Peterman, Shadab Ahmad, Gouri Vadali, Wenjun Deng, Ignacio Inglessis, Tom Wickham, Kathleen Feeney, G William Dec, Igor Palacios, Ferdinando S Buonanno…

    Citation: Clinical Proteomics 2015 12:2

    Content type: Research

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  2. Psoriatic arthritis (PsA) is a distinct inflammatory arthritis occurring in 30% of psoriasis patients. There is a high prevalence of undiagnosed PsA in psoriasis patients; therefore, identifying soluble biomar...

    Authors: Daniela Cretu, Kun Liang, Punit Saraon, Ihor Batruch, Eleftherios P Diamandis and Vinod Chandran

    Citation: Clinical Proteomics 2015 12:1

    Content type: Research

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  3. In the past two decades, our ability to study cellular and molecular systems has been transformed through the development of omics sciences. While unlimited potential lies within massive omics datasets, the su...

    Authors: Emily S Boja, Christopher R Kinsinger, Henry Rodriguez and Pothur Srinivas

    Citation: Clinical Proteomics 2014 11:45

    Content type: Meeting report

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  4. A combination treatment of interferon and ribavirin is the standard and the commonly used treatment for chronic hepatitis C (CHC). Developing noninvasive tests like serum indicators that can predict treatment ...

    Authors: Xia Zou, Xiumei Chi, Yu Pan, Dongning Du, Haibo Sun, Atsushi Matsuda, Wei Li, Atsushi Kuno, Xinxin Zhang, Hisashi Narimatsu, Junqi Niu and Yan Zhang

    Citation: Clinical Proteomics 2014 11:44

    Content type: Research

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  5. In our previous study that characterized different human CD4+ lymphocyte preparations, it was found that both commercially available cryopreserved peripheral blood mononuclear cells (PBMC) and a commercially a...

    Authors: Meiyao Wang, Martin Misakian, Hua-Jun He, Peter Bajcsy, Fatima Abbasi, Jeffrey M Davis, Kenneth D Cole, Illarion V Turko and Lili Wang

    Citation: Clinical Proteomics 2014 11:43

    Content type: Research

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  6. Pancreatic cysts are being increasingly identified in patients. Mucinous cysts have malignant potential whereas non-mucinous cysts do not. Distinguishing potentially malignant cysts from harmless ones by the c...

    Authors: John M Streitz, Michael T Madden, Wilmar Salo, Kirk P Bernadino, Joseph L Deutsch and John C Deutsch

    Citation: Clinical Proteomics 2014 11:42

    Content type: Research

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  7. Fibroblasts are mesenchymal stromal cells which occur in all tissue types. While their main function is related to ECM production and physical support, they are also important players in wound healing, and hav...

    Authors: Astrid Slany, Anastasia Meshcheryakova, Agnes Beer, Hendrik Jan Ankersmit, Verena Paulitschke and Christopher Gerner

    Citation: Clinical Proteomics 2014 11:41

    Content type: Research

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  8. Placental syncytiotrophoblast microvesicles (STBM) are shed into the maternal circulation during normal pregnancy. STBM circulate in significantly increased amounts in preeclampsia (PE) and are considered to b...

    Authors: Sonia Baig, Narasimhan Kothandaraman, Jayapal Manikandan, Li Rong, Kim Huey EE, Jeffrey Hill, Chin Wee Lai, Wan Yu Tan, Felicia Yeoh, Anita Kale, Lin Lin Su, Arijit Biswas, Sheila Vasoo and Mahesh Choolani

    Citation: Clinical Proteomics 2014 11:40

    Content type: Research

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  9. Toxoplasma encephalitis is caused by the opportunistic protozoan parasite Toxoplasma gondii. Primary infection with T. gondii in immunocompetent individuals remains largely asymptomatic. In contrast, in immunocom...

    Authors: Apeksha Sahu, Satwant Kumar, Sreelakshmi K Sreenivasamurthy, Lakshmi Dhevi N Selvan, Anil K Madugundu, Soujanya D Yelamanchi, Vinuth N Puttamallesh, Gourav Dey, Abhijith K Anil, Anand Srinivasan, Kanchan K Mukherjee, Harsha Gowda, Parthasarathy Satishchandra, Anita Mahadevan, Akhilesh Pandey, Thottethodi Subrahmanya Keshava Prasad…

    Citation: Clinical Proteomics 2014 11:39

    Content type: Research

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  10. The use of targeted LC-MS/MS methods for protein quantitation in clinical laboratories implies a careful evaluation of potential sources of analytical interference. In this study, we investigated whether infla...

    Authors: Olivier Lassout, Denis Hochstrasser and Pierre Lescuyer

    Citation: Clinical Proteomics 2014 11:38

    Content type: Research

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  11. The human epidermal growth factor receptor-2 (HER-2) expression level is a critical element for determining the prognosis and management of breast cancer. HER-2 targeted therapy in breast cancer depends on the...

    Authors: Candice Perry, Catherine M Conway, Jeong Won Ha, Till Braunschweig, Jennifer Morris, Kris Ylaya, Hanbyoul Cho, Joon-Yong Chung and Stephen M Hewitt

    Citation: Clinical Proteomics 2014 11:36

    Content type: Research

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  12. Rheumatic fever in childhood is the most common cause of Mitral Stenosis in developing countries. The disease is characterized by damaged and deformed mitral valves predisposing them to scarring and narrowing ...

    Authors: Somaditya Mukherjee, Mashanipalya G Jagadeeshaprasad, Tanima Banerjee, Sudip K Ghosh, Monodeep Biswas, Santanu Dutta, Mahesh J Kulkarni, Sanjib Pattari and Arun Bandyopadhyay

    Citation: Clinical Proteomics 2014 11:35

    Content type: Research

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  13. Cardiac diseases (e.g. coronary and valve) are associated with ventricular cellular remodeling. However, ventricular biopsies from left and right ventricles from patients with different pathologies are rare an...

    Authors: Ben Littlejohns, Kate Heesom, Gianni D Angelini and M-Saadeh Suleiman

    Citation: Clinical Proteomics 2014 11:34

    Content type: Research

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  14. Osteoarthritis (OA) is considered the most prevalent form of arthritis. The aim of this study was to verify potential protein OA biomarkers by applying Selected Reaction Monitoring (SRM) assays to protein extr...

    Authors: Emilio Camafeita, José-Ramón Lamas, Enrique Calvo, Pilar Tornero-Esteban, Juan-Antonio López and Benjamín Fernández-Gutiérrez

    Citation: Clinical Proteomics 2014 11:33

    Content type: Letter to the editor

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  15. CT screening for lung cancer is effective in reducing mortality, but there are areas of concern, including a positive predictive value of 4% and development of interval cancers. A blood test that could manage ...

    Authors: Michael R Mehan, Stephen A Williams, Jill M Siegfried, William L Bigbee, Joel L Weissfeld, David O Wilson, Harvey I Pass, William N Rom, Thomas Muley, Michael Meister, Wilbur Franklin, York E Miller, Edward N Brody and Rachel M Ostroff

    Citation: Clinical Proteomics 2014 11:32

    Content type: Research

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  16. Until now, the major prognostic factors for pediatric acute lymphoblastic leukemia (ALL), age, white blood cell count and chromosomal alterations are initially taken into account for the risk stratification of...

    Authors: Odile Costa, Pascale Schneider, Laurent Coquet, Philippe Chan, Dominique Penther, Elisabeth Legrand, Thierry Jouenne, Marc Vasse and Jean-Pierre Vannier

    Citation: Clinical Proteomics 2014 11:31

    Content type: Research

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  17. The proteomic analysis of body fluids is a growing technology for the identification of protein biomarkers of disease. Given that Papanicolaou tests (Pap tests) are routinely performed on over 30 million women...

    Authors: Kristin LM Boylan, Somaieh Afiuni-Zadeh, Melissa A Geller, Kayla Hickey, Timothy J Griffin, Stefan E Pambuccian and Amy PN Skubitz

    Citation: Clinical Proteomics 2014 11:30

    Content type: Research

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  18. The vitreous humor is a transparent, gelatinous mass whose main constituent is water. It plays an important role in providing metabolic nutrient requirements of the lens, coordinating eye growth and providing ...

    Authors: Krishna R Murthy, Renu Goel, Yashwanth Subbannayya, Harrys KC Jacob, Praveen R Murthy, Srikanth Srinivas Manda, Arun H Patil, Rakesh Sharma, Nandini A Sahasrabuddhe, Arun Parashar, Bipin G Nair, Venkatarangaiah Krishna, TS Keshava Prasad, Harsha Gowda and Akhilesh Pandey

    Citation: Clinical Proteomics 2014 11:29

    Content type: Research

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  19. The growing field of formalin-fixed paraffin-embedded (FFPE) tissue proteomics holds promise for improving translational research. Direct tissue trypsinization (DT) and protein extraction followed by in soluti...

    Authors: Alessandro Tanca, Marcello Abbondio, Salvatore Pisanu, Daniela Pagnozzi, Sergio Uzzau and Maria Filippa Addis

    Citation: Clinical Proteomics 2014 11:28

    Content type: Research

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  20. Synovial fluid (SF) is a dynamic reservoir for proteins originating from the synovial membrane, cartilage, and plasma, and may therefore reflect the pathophysiological conditions that give rise to arthritis. O...

    Authors: Daniela Cretu, Ioannis Prassas, Punit Saraon, Ihor Batruch, Rajiv Gandhi, Eleftherios P Diamandis and Vinod Chandran

    Citation: Clinical Proteomics 2014 11:27

    Content type: Research

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  21. Dysregulation of glycoproteins is closely related with many diseases. Quantitative proteomics methods are powerful tools for the detection of glycoprotein alterations. However, in almost all quantitative glyco...

    Authors: Zhen Sun, Deguang Sun, Fangjun Wang, Kai Cheng, Zhang Zhang, Bo Xu, Mingliang Ye, Liming Wang and Hanfa Zou

    Citation: Clinical Proteomics 2014 11:26

    Content type: Research

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  22. Glycoproteins comprise a large portion of the salivary proteome and have great potential for biomarker discovery and disease diagnosis. However, the rate of production and the concentration of whole saliva cha...

    Authors: Shisheng Sun, Fei Zhao, Qinzhe Wang, Yaogang Zhong, Tanxi Cai, Peng Wu, Fuquan Yang and Zheng Li

    Citation: Clinical Proteomics 2014 11:25

    Content type: Research

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  23. Histone post-translational modifications (PTMs) play an important role in the regulation of the expression of genes, including those involved in cancer development and progression. However, our knowledge of PT...

    Authors: Jakub Karczmarski, Tymon Rubel, Agnieszka Paziewska, Michal Mikula, Mateusz Bujko, Paulina Kober, Michal Dadlez and Jerzy Ostrowski

    Citation: Clinical Proteomics 2014 11:24

    Content type: Research

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  24. Ovarian cancer (OvCa) is the most lethal gynecological malignancy. The emergence of high-throughput technologies, such as mass spectrometry, has allowed for a paradigm shift in the way we search for novel biom...

    Authors: Christopher R Smith, Ihor Batruch, Josep Miquel Bauça, Hari Kosanam, Julia Ridley, Marcus Q Bernardini, Felix Leung, Eleftherios P Diamandis and Vathany Kulasingam

    Citation: Clinical Proteomics 2014 11:23

    Content type: Research

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  25. Protein glycosylation, as an important post-translational modification, is implicated in a number of ailments. Applying proteomic approaches, including mass spectrometry (MS) analyses that have played a signif...

    Authors: Hu Zhao, Yaojun Li and Ye Hu

    Citation: Clinical Proteomics 2014 11:21

    Content type: Review

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  26. Adipose tissue is both an energy storage depot and an endocrine organ. The impaired regulation of the secreted proteins of adipose tissue, known as adipocytokines, observed during obesity contributes to the on...

    Authors: Jae-Min Lim, Edith E Wollaston-Hayden, Chin Fen Teo, Dorothy Hausman and Lance Wells

    Citation: Clinical Proteomics 2014 11:20

    Content type: Research

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  27. Estrogen has been shown to mediate protection in female hearts against ischemia-reperfusion (I-R) stress. Composed by a Kir6.2 pore and an SUR2 regulatory subunit, cardiac ATP-sensitive potassium channels (KAT...

    Authors: Jianjiong Gao, Dong Xu, Grzegorz Sabat, Hector Valdivia, Wei Xu and Nian-Qing Shi

    Citation: Clinical Proteomics 2014 11:19

    Content type: Research

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  28. Peritoneal dialysis (PD) is a form of renal replacement used for advanced chronic kidney disease. PD effluent holds a great potential for biomarker discovery for diagnosis and prognosis. In this study a novel ...

    Authors: Elisabete Oliveira, José E Araújo, Silvana Gómez-Meire, Carlos Lodeiro, Cristina Perez-Melon, Elena Iglesias-Lamas, Alfonso Otero-Glez, José L Capelo and Hugo M Santos

    Citation: Clinical Proteomics 2014 11:17

    Content type: Research

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  29. Gel- based proteomics is one of the most versatile methods for fractionating protein complexes. Among these methods, two dimensional- polyacrylamide gel electrophoresis (2-DE) represents a mainstay orthogonal ...

    Authors: Sameh Magdeldin, Shymaa Enany, Yutaka Yoshida, Bo Xu, Ying Zhang, Zam Zureena, Ilambarthi Lokamani, Eishin Yaoita and Tadashi Yamamoto

    Citation: Clinical Proteomics 2014 11:16

    Content type: Review

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  30. Protein glycosylation serves critical roles in the cellular and biological processes of many organisms. Aberrant glycosylation has been associated with many illnesses such as hereditary and chronic diseases li...

    Authors: Deniz Baycin Hizal, Daniel Wolozny, Joseph Colao, Elena Jacobson, Yuan Tian, Sharon S Krag, Michael J Betenbaugh and Hui Zhang

    Citation: Clinical Proteomics 2014 11:15

    Content type: Review

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  31. Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associate...

    Authors: Huan Liu, Ningbo Zhang, Debin Wan, Meng Cui, Zhiqiang Liu and Shuying Liu

    Citation: Clinical Proteomics 2014 11:14

    Content type: Review

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  32. Conventional proteomic approaches have thus far been unable to identify novel serum biomarkers for ovarian cancer that are more sensitive and specific than the current clinically used marker, CA-125. Because e...

    Authors: Anand Bery, Felix Leung, Christopher R Smith, Eleftherios P Diamandis and Vathany Kulasingam

    Citation: Clinical Proteomics 2014 11:13

    Content type: Research

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  33. Transthyretin (TTR), an abundant protein in cerebrospinal fluid (CSF), contains a free, oxidation-prone cysteine residue that gives rise to TTR isoforms. These isoforms may reflect conditions in vivo. Since incre...

    Authors: Keld Poulsen, Justyna MC Bahl, Anja H Simonsen, Steen G Hasselbalch and Niels HH Heegaard

    Citation: Clinical Proteomics 2014 11:12

    Content type: Research

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  34. It is well known that cell surface glycans or glycocalyx play important roles in sperm motility, maturation and fertilization. A comprehensive profile of the sperm surface glycans will greatly facilitate both ...

    Authors: Ai-Jie Xin, Li Cheng, Hua Diao, Peng Wang, Yi-Hua Gu, Bin Wu, Yan-Cheng Wu, Guo-Wu Chen, Shu-Min Zhou, Shu-Juan Guo, Hui-Juan Shi and Sheng-Ce Tao

    Citation: Clinical Proteomics 2014 11:10

    Content type: Research

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  35. Glycoproteins secreted into plasma from T cells infected with human immunodeficiency virus (HIV) latent infection may provide insight into understanding the host response to HIV infection in vivo. Glycoproteomics...

    Authors: Weiming Yang, Jian-Ying Zhou, Li Chen, Minghui Ao, Shisheng Sun, Paul Aiyetan, Antoine Simmons, Hui Zhang and Jay Brooks Jackson

    Citation: Clinical Proteomics 2014 11:9

    Content type: Research

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  36. O-linked β-D-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) onto serine and threonine residues of proteins is an important post-translational modification (PTM), which is involved in many crucial b...

    Authors: Junfeng Ma and Gerald W Hart

    Citation: Clinical Proteomics 2014 11:8

    Content type: Review

    Published on:

  37. Analysis of native or endogenous peptides in biofluids can provide valuable insights into disease mechanisms. Furthermore, the detected peptides may also have utility as potential biomarkers for non-invasive m...

    Authors: Tara K Sigdel, Carrie D Nicora, Szu-Chuan Hsieh, Hong Dai, Wei-Jun Qian, David G Camp II and Minnie M Sarwal

    Citation: Clinical Proteomics 2014 11:7

    Content type: Research

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  38. Osteoarthritis is a chronic musculoskeletal disorder characterized mainly by progressive degradation of the hyaline cartilage. Patients with osteoarthritis often postpone seeking medical help, which results in...

    Authors: Lavanya Balakrishnan, Raja Sekhar Nirujogi, Sartaj Ahmad, Mitali Bhattacharjee, Srikanth S Manda, Santosh Renuse, Dhanashree S Kelkar, Yashwanth Subbannayya, Rajesh Raju, Renu Goel, Joji Kurian Thomas, Navjyot Kaur, Mukesh Dhillon, Shantal Gupta Tankala, Ramesh Jois, Vivek Vasdev…

    Citation: Clinical Proteomics 2014 11:6

    Content type: Research

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  39. Cryptococcus neoformans, a basidiomycetous fungus of universal occurrence, is a significant opportunistic human pathogen causing meningitis. Owing to an increase in the number of immunosuppressed individuals alon...

    Authors: Lakshmi Dhevi Nagarajha Selvan, Jyothi Embekkat Kaviyil, Raja Sekhar Nirujogi, Babylakshmi Muthusamy, Vinuth N Puttamallesh, Tejaswini Subbannayya, Nazia Syed, Aneesha Radhakrishnan, Dhanashree S Kelkar, Sartaj Ahmad, Sneha M Pinto, Praveen Kumar, Anil K Madugundu, Bipin Nair, Aditi Chatterjee, Akhilesh Pandey…

    Citation: Clinical Proteomics 2014 11:5

    Content type: Research

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  40. Numerous formaldehyde-fixed and paraffin-embedded clinical tissues have been created in the past decades and stored in pathological depositories at hospitals as well as in clinical laboratories worldwide. In a...

    Authors: Yusuke Kawashima, Yoshio Kodera, Anil Singh, Masaomi Matsumoto and Hiroyuki Matsumoto

    Citation: Clinical Proteomics 2014 11:4

    Content type: Research

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  41. Protein biomarkers offer major benefits for diagnosis and monitoring of disease processes. Recent advances in protein mass spectrometry make it feasible to use this very sensitive technology to detect and quan...

    Authors: John Marshall, Peter Bowden, Jean Claude Schmit and Fay Betsou

    Citation: Clinical Proteomics 2014 11:3

    Content type: Research

    Published on:

  42. Experts agree that one of the more promising strategies in cancer management is early detection coupled with early intervention. In this study, we evaluated an early cancer detection strategy of cancer presenc...

    Authors: Claudia Hanau, D James Morré and Dorothy M Morré

    Citation: Clinical Proteomics 2014 11:2

    Content type: Research

    Published on:

  43. Rheumatoid arthritis and osteoarthritis are two common musculoskeletal disorders that affect the joints. Despite high prevalence rates, etiological factors involved in these disorders remain largely unknown. D...

    Authors: Lavanya Balakrishnan, Mitali Bhattacharjee, Sartaj Ahmad, Raja Sekhar Nirujogi, Santosh Renuse, Yashwanth Subbannayya, Arivusudar Marimuthu, Srinivas M Srikanth, Rajesh Raju, Mukesh Dhillon, Navjyot Kaur, Ramesh Jois, Vivek Vasudev, YL Ramachandra, Nandini A Sahasrabuddhe, TS Keshava Prasad…

    Citation: Clinical Proteomics 2014 11:1

    Content type: Research

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  44. Plasma renin activity (PRA) is an essential analytical tool for screening and diagnosis of secondary forms of hypertension. Typically, PRA is measured by competitive radioimmunoassay, but there are significant...

    Authors: Alexander G Camenzind, Jessica Grace van der Gugten, Robert Popp, Daniel T Holmes and Christoph H Borchers

    Citation: Clinical Proteomics 2013 10:20

    Content type: Research

    Published on:

  45. Potential biomarkers to aid diagnosis and therapy need to be identified for Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The present study was designed to identify the fac...

    Authors: Anu Mary Varghese, Aparna Sharma, Poojashree Mishra, Kalyan Vijayalakshmi, Hindalahalli Chandregowda Harsha, Talakad N Sathyaprabha, Srinivas MM Bharath, Atchayaram Nalini, Phalguni Anand Alladi and Trichur R Raju

    Citation: Clinical Proteomics 2013 10:19

    Content type: Research

    Published on:

  46. The rapid advancement of high-throughput tools for quantitative measurement of proteins has demonstrated the potential for the identification of proteins associated with cancer. However, the quantitative resul...

    Authors: Jing Chen, Shadi Toghi Eshghi, George Steven Bova, Qing Kay Li, Xingde Li and Hui Zhang

    Citation: Clinical Proteomics 2013 10:18

    Content type: Research

    Published on:

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